Total Synthesis of Phorboxazole B
Lucas, Brian S., Gopalsamuthiram, Vijayagopal, Burke, Steven D.
Published in Angewandte Chemie International Edition (01.01.2007)
Published in Angewandte Chemie International Edition (01.01.2007)
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Desymmetrization of a Propane-1,3-diol to Introduce the Quaternary Chiral Center of an AMG 176 Drug Substance Intermediate
Ananthoji, Padmini K. K., Arunachalampillai, Athimoolam, Beaver, Matthew G. G., Fang, Yuan-Qing, Hedley, Simon J. J., Lucas, Brian S. S., Tedrow, Jason S. S., Faul, Margaret M. M.
Published in Synthesis (Stuttgart) (01.08.2023)
Published in Synthesis (Stuttgart) (01.08.2023)
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An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553
Lucas, Brian S, Fisher, Benjamin, McGee, Lawrence R, Olson, Steven H, Medina, Julio C, Cheung, Eugene
Published in Journal of the American Chemical Society (01.08.2012)
Published in Journal of the American Chemical Society (01.08.2012)
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Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2‑((1S)‑1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro‑N‑methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
Gonzalez-Lopez de Turiso, Felix, Hao, Xiaolin, Shin, Youngsook, Bui, Minna, Campuzano, Iain D. G, Cardozo, Mario, Dunn, Michelle C, Duquette, Jason, Fisher, Benjamin, Foti, Robert S, Henne, Kirk, He, Xiao, Hu, Yi-Ling, Kelly, Ron C, Johnson, Michael G, Lucas, Brian S, McCarter, John, McGee, Lawrence R, Medina, Julio C, Metz, Daniela, San Miguel, Tisha, Mohn, Deanna, Tran, Thuy, Vissinga, Christine, Wannberg, Sharon, Whittington, Douglas A, Whoriskey, John, Yu, Gang, Zalameda, Leeanne, Zhang, Xuxia, Cushing, Timothy D
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines
Kaizerman, Jacob A., Aaron, Wade, An, Songzhu, Austin, Richard, Brown, Matt, Chong, Angela, Huang, Tom, Hungate, Randall, Jiang, Ben, Johnson, Michael G., Lee, Gary, Lucas, Brian S., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy, McMinn, Dustin L.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit
Brown, Matthew L., Aaron, Wade, Austin, Richard J., Chong, Angela, Huang, Tom, Jiang, Ben, Kaizerman, Jacob A., Lee, Gary, Lucas, Brian S., McMinn, Dustin L., Orf, Jessica, Rong, Minqing, Toteva, Maria M., Xu, Guifen, Ye, Qiuping, Zhong, Wendy, DeGraffenreid, Michael R., Wickramasinghe, Dineli, Powers, Jay P., Hungate, Randall, Johnson, Michael G.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists
Lucas, Brian S., Aaron, Wade, An, Songzhu, Austin, Richard J., Brown, Matthew, Chan, Hon, Chong, Angela, Hungate, Randall, Huang, Tom, Jiang, Ben, Johnson, Michael G., Kaizerman, Jacob A., Lee, Gary, McMinn, Dustin L., Orf, Jessica, Powers, Jay P., Rong, Minqing, Toteva, Maria M., Uyeda, Craig, Wickramasinghe, Dineli, Xu, Guifen, Ye, Qiuping, Zhong, Wendy
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
A Catalytic Enantioselective Hetero Diels−Alder Approach to the C20−C32 Segment of the Phorboxazoles
Lucas, Brian S, Luther, Laura M, Burke, Steven D
Published in Journal of organic chemistry (29.04.2005)
Published in Journal of organic chemistry (29.04.2005)
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Journal Article
MDM2 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
COCHRAN BRIAN, WIEDEMANN SEAN, FOX BRIAN M, CAILLE SEBASTIEN, BIO MATTHEW, WORTMAN SARAH, LUCAS BRIAN S, VOUNATSOS FILISATY, MCGEE LAWRENCE R, FANG YUANQING
Year of Publication 07.02.2023
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Year of Publication 07.02.2023
Patent
MDM2 PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
COCHRAN BRIAN, WIEDEMANN SEAN, FOX BRIAN M, CAILLE SEBASTIEN, BIO MATTHEW, WORTMAN SARAH, LUCAS BRIAN S, VOUNATSOS FILISATY, MCGEE LAWRENCE R, FANG YUANQING
Year of Publication 07.10.2021
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Year of Publication 07.10.2021
Patent
Development of an Efficient Process for the Preparation of Sch 39166: Aziridinium Chemistry on Scale
Gala, Dinesh, Dahanukar, Vilas H, Eckert, Jeffery M, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A, Buholzer, Patrik, Kubisch, Peter, Mergelsberg, Ingrid, Scherer, Dominik
Published in Organic process research & development (01.09.2004)
Published in Organic process research & development (01.09.2004)
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Reaction of aziridinium ions with organometallic reagents: optimization of the key step of ecopipam synthesis
Andrews, David R, Dahanukar, Vilas H, Eckert, Jeffrey M, Gala, Dinesh, Lucas, Brian S, Schumacher, Doris P, Zavialov, Ilia A
Published in Tetrahedron letters (26.08.2002)
Published in Tetrahedron letters (26.08.2002)
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Journal Article
MCL-1 TETRAHYDRONAPHTHALENE DERIVATIVES THAT INHIBIT MCL-1 PROTEIN
WANG XIANGHONG, BROWN SEAN P, LIZARZABURU MIKE ELIAS, PARAS NICK A, LI ZHIHONG, LI YUNXIAO, TAYGERLY JOSHUA, ZHU LIUSHENG, ZANCANELLA MANUEL, YU MING, LUCAS BRIAN S, VIMOLRATANA MARC, GONZALEZ BUENROSTRO ANA
Year of Publication 21.04.2017
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Year of Publication 21.04.2017
Patent
PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
COCHRAN BRIAN, WIEDEMANN SEAN, FOX BRIAN M, CAILLE SEBASTIEN, BIO MATTHEW, WORTMAN SARAH, LUCAS BRIAN S, VOUNATSOS FILISATY, MCGEE LAWRENCE R, FANG YUANQING
Year of Publication 17.02.2016
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Year of Publication 17.02.2016
Patent
Anaesthesia in a parturient with Noonan's syndrome
GRANGE, C. S, HEID, R, LUCAS, S. B, ROSS, P. L. E, DOUGLAS, M. J
Published in Canadian journal of anesthesia (01.04.1998)
Published in Canadian journal of anesthesia (01.04.1998)
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