Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution
Dietzen, Michelle, Zhai, Haoran, Lucas, Olivia, Pich, Oriol, Barrington, Christopher, Lu, Wei-Ting, Ward, Sophia, Guo, Yanping, Hynds, Robert E, Zaccaria, Simone, Swanton, Charles, McGranahan, Nicholas, Kanu, Nnennaya
Published in Nature communications (18.07.2024)
Published in Nature communications (18.07.2024)
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Lung adenocarcinoma promotion by air pollutants
Hill, William, Lim, Emilia L, Weeden, Clare E, Lee, Claudia, Augustine, Marcellus, Chen, Kezhong, Kuan, Feng-Che, Marongiu, Fabio, Evans, Jr, Edward J, Moore, David A, Rodrigues, Felipe S, Pich, Oriol, Bakker, Bjorn, Cha, Hongui, Myers, Renelle, van Maldegem, Febe, Boumelha, Jesse, Veeriah, Selvaraju, Rowan, Andrew, Naceur-Lombardelli, Cristina, Karasaki, Takahiro, Sivakumar, Monica, De, Swapnanil, Caswell, Deborah R, Nagano, Ai, Black, James R M, Martínez-Ruiz, Carlos, Ryu, Min Hyung, Huff, Ryan D, Li, Shijia, Favé, Marie-Julie, Magness, Alastair, Suárez-Bonnet, Alejandro, Priestnall, Simon L, Lüchtenborg, Margreet, Lavelle, Katrina, Pethick, Joanna, Hardy, Steven, McRonald, Fiona E, Lin, Meng-Hung, Troccoli, Clara I, Ghosh, Moumita, Miller, York E, Merrick, Daniel T, Keith, Robert L, Al Bakir, Maise, Bailey, Chris, Hill, Mark S, Saal, Lao H, Chen, Yilun, George, Anthony M, Abbosh, Christopher, Kanu, Nnennaya, Lee, Se-Hoon, McGranahan, Nicholas, Berg, Christine D, Sasieni, Peter, Houlston, Richard, Turnbull, Clare, Lam, Stephen, Awadalla, Philip, Grönroos, Eva, Downward, Julian, Jacks, Tyler, Carlsten, Christopher, Malanchi, Ilaria, Hackshaw, Allan, Litchfield, Kevin, DeGregori, James, Jamal-Hanjani, Mariam, Swanton, Charles
Published in Nature (London) (06.04.2023)
Published in Nature (London) (06.04.2023)
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Perifollicular inflammation and follicular spongiosis in androgenetic alopecia
Plante, John, Valdebran, Manuel, Forcucci, Jessica, Lucas, Olivia, Elston, Dirk
Published in Journal of the American Academy of Dermatology (01.02.2022)
Published in Journal of the American Academy of Dermatology (01.02.2022)
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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Abbosh, Christopher, Frankell, Alexander M, Harrison, Thomas, Kisistok, Judit, Garnett, Aaron, Johnson, Laura, Veeriah, Selvaraju, Moreau, Mike, Chesh, Adrian, Chaunzwa, Tafadzwa L, Weiss, Jakob, Schroeder, Morgan R, Ward, Sophia, Grigoriadis, Kristiana, Shahpurwalla, Aamir, Litchfield, Kevin, Puttick, Clare, Biswas, Dhruva, Karasaki, Takahiro, Black, James R M, Martínez-Ruiz, Carlos, Bakir, Maise Al, Pich, Oriol, Watkins, Thomas B K, Lim, Emilia L, Huebner, Ariana, Moore, David A, Godin-Heymann, Nadia, L'Hernault, Anne, Bye, Hannah, Odell, Aaron, Roberts, Paula, Gomes, Fabio, Patel, Akshay J, Manzano, Elizabeth, Hiley, Crispin T, Carey, Nicolas, Riley, Joan, Cook, Daniel E, Hodgson, Darren, Stetson, Daniel, Barrett, J Carl, Kortlever, Roderik M, Evan, Gerard I, Hackshaw, Allan, Daber, Robert D, Shaw, Jacqui A, Aerts, Hugo J W L, Licon, Abel, Stahl, Josh, Jamal-Hanjani, Mariam, Birkbak, Nicolai J, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London) (20.04.2023)
Published in Nature (London) (20.04.2023)
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The evolution of lung cancer and impact of subclonal selection in TRACERx
Frankell, Alexander M, Dietzen, Michelle, Al Bakir, Maise, Lim, Emilia L, Karasaki, Takahiro, Ward, Sophia, Veeriah, Selvaraju, Colliver, Emma, Huebner, Ariana, Bunkum, Abigail, Hill, Mark S, Grigoriadis, Kristiana, Moore, David A, Black, James R M, Liu, Wing Kin, Thol, Kerstin, Pich, Oriol, Watkins, Thomas B K, Naceur-Lombardelli, Cristina, Cook, Daniel E, Salgado, Roberto, Wilson, Gareth A, Bailey, Chris, Angelova, Mihaela, Bentham, Robert, Martínez-Ruiz, Carlos, Abbosh, Christopher, Nicholson, Andrew G, Le Quesne, John, Biswas, Dhruva, Rosenthal, Rachel, Puttick, Clare, Hessey, Sonya, Lee, Claudia, Prymas, Paulina, Toncheva, Antonia, Smith, Jon, Xing, Wei, Nicod, Jerome, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Blyth, Kevin G, Fennell, Dean A, Forster, Martin D, Lee, Siow Ming, Falzon, Mary, Hewish, Madeleine, Shackcloth, Michael J, Lim, Eric, Benafif, Sarah, Russell, Peter, Boleti, Ekaterini, Krebs, Matthew G, Lester, Jason F, Papadatos-Pastos, Dionysis, Ahmad, Tanya, Thakrar, Ricky M, Lawrence, David, Navani, Neal, Janes, Sam M, Dive, Caroline, Blackhall, Fiona H, Summers, Yvonne, Cave, Judith, Marafioti, Teresa, Herrero, Javier, Quezada, Sergio A, Peggs, Karl S, Schwarz, Roland F, Van Loo, Peter, Miedema, Daniël M, Birkbak, Nicolai J, Hiley, Crispin T, Hackshaw, Allan, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London) (20.04.2023)
Published in Nature (London) (20.04.2023)
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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
Virassamy, Balaji, Caramia, Franco, Savas, Peter, Sant, Sneha, Wang, Jianan, Christo, Susan N., Byrne, Ann, Clarke, Kylie, Brown, Emmaline, Teo, Zhi Ling, von Scheidt, Bianca, Freestone, David, Gandolfo, Luke C., Weber, Karsten, Teply-Szymanski, Julia, Li, Ran, Luen, Stephen J., Denkert, Carsten, Loibl, Sibylle, Lucas, Olivia, Swanton, Charles, Speed, Terence P., Darcy, Phillip K., Neeson, Paul J., Mackay, Laura K., Loi, Sherene
Published in Cancer cell (13.03.2023)
Published in Cancer cell (13.03.2023)
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Antibodies against endogenous retroviruses promote lung cancer immunotherapy
Ng, Kevin W, Boumelha, Jesse, Enfield, Katey S S, Almagro, Jorge, Cha, Hongui, Pich, Oriol, Karasaki, Takahiro, Moore, David A, Salgado, Roberto, Sivakumar, Monica, Young, George, Molina-Arcas, Miriam, de Carné Trécesson, Sophie, Anastasiou, Panayiotis, Fendler, Annika, Au, Lewis, Shepherd, Scott T C, Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R M, Watkins, Thomas B K, Kim, Hyemin, Shim, Seohee, Faulkner, Nikhil, Attig, Jan, Veeriah, Selvaraju, Magno, Neil, Ward, Sophia, Frankell, Alexander M, Al Bakir, Maise, Lim, Emilia L, Hill, Mark S, Wilson, Gareth A, Cook, Daniel E, Birkbak, Nicolai J, Behrens, Axel, Yousaf, Nadia, Popat, Sanjay, Hackshaw, Allan, Hiley, Crispin T, Litchfield, Kevin, McGranahan, Nicholas, Jamal-Hanjani, Mariam, Larkin, James, Lee, Se-Hoon, Turajlic, Samra, Swanton, Charles, Downward, Julian, Kassiotis, George
Published in Nature (London) (20.04.2023)
Published in Nature (London) (20.04.2023)
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The evolution of non-small cell lung cancer metastases in TRACERx
Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B K, Pich, Oriol, Moore, David A, Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander M, Bunkum, Abigail, Lim, Emilia L, Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T, Hill, Mark S, Cook, Daniel E, Wilson, Gareth A, Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A, Price, Gillian, Kerr, Keith M, Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R, Blackhall, Fiona H, Cave, Judith, Blyth, Kevin G, Nair, Arjun, Ahmed, Asia, Taylor, Magali N, Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M, Janes, Sam M, Papadatos-Pastos, Dionysis, Forster, Martin D, Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio A, Peggs, Karl S, Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J, Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles
Published in Nature (London) (20.04.2023)
Published in Nature (London) (20.04.2023)
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Genomic-transcriptomic evolution in lung cancer and metastasis
Martínez-Ruiz, Carlos, Black, James R M, Puttick, Clare, Hill, Mark S, Demeulemeester, Jonas, Larose Cadieux, Elizabeth, Thol, Kerstin, Jones, Thomas P, Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Prymas, Paulina, Rowan, Andrew, Ward, Sophia, Cubitt, Laura, Athanasopoulou, Foteini, Pich, Oriol, Karasaki, Takahiro, Moore, David A, Salgado, Roberto, Colliver, Emma, Castignani, Carla, Dietzen, Michelle, Huebner, Ariana, Al Bakir, Maise, Tanić, Miljana, Watkins, Thomas B K, Lim, Emilia L, Al-Rashed, Ali M, Lang, Danny, Clements, James, Cook, Daniel E, Rosenthal, Rachel, Wilson, Gareth A, Frankell, Alexander M, de Carné Trécesson, Sophie, East, Philip, Kanu, Nnennaya, Litchfield, Kevin, Birkbak, Nicolai J, Hackshaw, Allan, Beck, Stephan, Van Loo, Peter, Jamal-Hanjani, Mariam, Swanton, Charles, McGranahan, Nicholas
Published in Nature (London) (20.04.2023)
Published in Nature (London) (20.04.2023)
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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx
Karasaki, Takahiro, Moore, David A, Veeriah, Selvaraju, Naceur-Lombardelli, Cristina, Toncheva, Antonia, Magno, Neil, Ward, Sophia, Bakir, Maise Al, Watkins, Thomas B K, Grigoriadis, Kristiana, Huebner, Ariana, Hill, Mark S, Frankell, Alexander M, Abbosh, Christopher, Puttick, Clare, Zhai, Haoran, Gimeno-Valiente, Francisco, Saghafinia, Sadegh, Kanu, Nnennaya, Dietzen, Michelle, Pich, Oriol, Lim, Emilia L, Martínez-Ruiz, Carlos, Black, James R M, Biswas, Dhruva, Campbell, Brittany B, Lee, Claudia, Colliver, Emma, Enfield, Katey S S, Hessey, Sonya, Hiley, Crispin T, Zaccaria, Simone, Litchfield, Kevin, Birkbak, Nicolai J, Cadieux, Elizabeth Larose, Demeulemeester, Jonas, Van Loo, Peter, Adusumilli, Prasad S, Tan, Kay See, Cheema, Waseem, Sanchez-Vega, Francisco, Jones, David R, Rekhtman, Natasha, Travis, William D, Hackshaw, Allan, Marafioti, Teresa, Salgado, Roberto, Le Quesne, John, Nicholson, Andrew G, McGranahan, Nicholas, Swanton, Charles, Jamal-Hanjani, Mariam
Published in Nature medicine (12.04.2023)
Published in Nature medicine (12.04.2023)
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Body composition and lung cancer-associated cachexia in TRACERx
Al-Sawaf, Othman, Weiss, Jakob, Skrzypski, Marcin, Lam, Jie Min, Karasaki, Takahiro, Zambrana, Francisco, Kidd, Andrew C, Frankell, Alexander M, Watkins, Thomas B K, Martínez-Ruiz, Carlos, Puttick, Clare, Black, James R M, Huebner, Ariana, Bakir, Maise Al, Sokač, Mateo, Collins, Susie, Veeriah, Selvaraju, Magno, Neil, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Ward, Sophia, Jayanth, Nick, Salgado, Roberto, Bridge, Christopher P, Christiani, David C, Mak, Raymond H, Bay, Camden, Rosenthal, Michael, Sattar, Naveed, Welsh, Paul, Liu, Ying, Perrimon, Norbert, Popuri, Karteek, Beg, Mirza Faisal, McGranahan, Nicholas, Hackshaw, Allan, Breen, Danna M, O'Rahilly, Stephen, Birkbak, Nicolai J, Aerts, Hugo J W L, Jamal-Hanjani, Mariam, Swanton, Charles
Published in Nature medicine (01.04.2023)
Published in Nature medicine (01.04.2023)
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Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models
Hynds, Robert E, Huebner, Ariana, Pearce, David R, Hill, Mark S, Akarca, Ayse U, Moore, David A, Ward, Sophia, Gowers, Kate H C, Karasaki, Takahiro, Al Bakir, Maise, Wilson, Gareth A, Pich, Oriol, Martínez-Ruiz, Carlos, Hossain, A S Md Mukarram, Pearce, Simon P, Sivakumar, Monica, Ben Aissa, Assma, Grönroos, Eva, Chandrasekharan, Deepak, Kolluri, Krishna K, Towns, Rebecca, Wang, Kaiwen, Cook, Daniel E, Bosshard-Carter, Leticia, Naceur-Lombardelli, Cristina, Rowan, Andrew J, Veeriah, Selvaraju, Litchfield, Kevin, Crosbie, Philip A J, Dive, Caroline, Quezada, Sergio A, Janes, Sam M, Jamal-Hanjani, Mariam, Marafioti, Teresa, McGranahan, Nicholas, Swanton, Charles
Published in Nature communications (31.05.2024)
Published in Nature communications (31.05.2024)
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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
Hobor, Sebastijan, Al Bakir, Maise, Hiley, Crispin T, Skrzypski, Marcin, Frankell, Alexander M, Bakker, Bjorn, Watkins, Thomas B K, Markovets, Aleksandra, Dry, Jonathan R, Brown, Andrew P, van der Aart, Jasper, van den Bos, Hilda, Spierings, Diana, Oukrif, Dahmane, Novelli, Marco, Chakrabarti, Turja, Rabinowitz, Adam H, Ait Hassou, Laila, Litière, Saskia, Kerr, D Lucas, Tan, Lisa, Kelly, Gavin, Moore, David A, Renshaw, Matthew J, Venkatesan, Subramanian, Hill, William, Huebner, Ariana, Martínez-Ruiz, Carlos, Black, James R M, Wu, Wei, Angelova, Mihaela, McGranahan, Nicholas, Downward, Julian, Chmielecki, Juliann, Barrett, Carl, Litchfield, Kevin, Chew, Su Kit, Blakely, Collin M, de Bruin, Elza C, Foijer, Floris, Vousden, Karen H, Bivona, Trever G, Hynds, Robert E, Kanu, Nnennaya, Zaccaria, Simone, Grönroos, Eva, Swanton, Charles
Published in Nature communications (13.06.2024)
Published in Nature communications (13.06.2024)
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