Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.
Published in Nature (London) (19.10.2017)
Published in Nature (London) (19.10.2017)
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Journal Article
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
Chen, Janice S, Ma, Enbo, Harrington, Lucas B, Da Costa, Maria, Tian, Xinran, Palefsky, Joel M, Doudna, Jennifer A
Published in Science (American Association for the Advancement of Science) (27.04.2018)
Published in Science (American Association for the Advancement of Science) (27.04.2018)
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Journal Article
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
Harrington, Lucas B, Burstein, David, Chen, Janice S, Paez-Espino, David, Ma, Enbo, Witte, Isaac P, Cofsky, Joshua C, Kyrpides, Nikos C, Banfield, Jillian F, Doudna, Jennifer A
Published in Science (American Association for the Advancement of Science) (16.11.2018)
Published in Science (American Association for the Advancement of Science) (16.11.2018)
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The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Sullivan, Lucas B., Martinez-Garcia, Eva, Nguyen, Hien, Mullen, Andrew R., Dufour, Eric, Sudarshan, Sunil, Licht, Jonathan D., Deberardinis, Ralph J., Chandel, Navdeep S.
Published in Molecular cell (25.07.2013)
Published in Molecular cell (25.07.2013)
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.
Published in Cell metabolism (08.03.2016)
Published in Cell metabolism (08.03.2016)
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Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Luengo, Alba, Li, Zhaoqi, Gui, Dan Y., Sullivan, Lucas B., Zagorulya, Maria, Do, Brian T., Ferreira, Raphael, Naamati, Adi, Ali, Ahmed, Lewis, Caroline A., Thomas, Craig J., Spranger, Stefani, Matheson, Nicholas J., Vander Heiden, Matthew G.
Published in Molecular cell (18.02.2021)
Published in Molecular cell (18.02.2021)
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Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM
Lanz, Tobias V., Brewer, R. Camille, Ho, Peggy P., Moon, Jae-Seung, Jude, Kevin M., Fernandez, Daniel, Fernandes, Ricardo A., Gomez, Alejandro M., Nadj, Gabriel-Stefan, Bartley, Christopher M., Schubert, Ryan D., Hawes, Isobel A., Vazquez, Sara E., Iyer, Manasi, Zuchero, J. Bradley, Teegen, Bianca, Dunn, Jeffrey E., Lock, Christopher B., Kipp, Lucas B., Cotham, Victoria C., Ueberheide, Beatrix M., Aftab, Blake T., Anderson, Mark S., DeRisi, Joseph L., Wilson, Michael R., Bashford-Rogers, Rachael J. M., Platten, Michael, Garcia, K. Christopher, Steinman, Lawrence, Robinson, William H.
Published in Nature (London) (10.03.2022)
Published in Nature (London) (10.03.2022)
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New CRISPR–Cas systems from uncultivated microbes
Burstein, David, Harrington, Lucas B., Strutt, Steven C., Probst, Alexander J., Anantharaman, Karthik, Thomas, Brian C., Doudna, Jennifer A., Banfield, Jillian F.
Published in Nature (London) (09.02.2017)
Published in Nature (London) (09.02.2017)
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Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin
Gui, Dan Y., Sullivan, Lucas B., Luengo, Alba, Hosios, Aaron M., Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M., Freinkman, Elizaveta, Thomas, Craig J., Vander Heiden, Matthew G.
Published in Cell metabolism (08.11.2016)
Published in Cell metabolism (08.11.2016)
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Journal Article
Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen
Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.
Published in Molecular cell (01.10.2015)
Published in Molecular cell (01.10.2015)
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Journal Article
Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y
Comeras, Lucas B., Herzog, Herbert, Tasan, Ramon O.
Published in Annals of the New York Academy of Sciences (01.11.2019)
Published in Annals of the New York Academy of Sciences (01.11.2019)
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Mechanisms, Consequences, and Prevention of Coronary Graft Failure
Gaudino, Mario, Antoniades, Charalambos, Benedetto, Umberto, Deb, Saswata, Di Franco, Antonino, Di Giammarco, Gabriele, Fremes, Stephen, Glineur, David, Grau, Juan, He, Guo-Wei, Marinelli, Daniele, Ohmes, Lucas B, Patrono, Carlo, Puskas, John, Tranbaugh, Robert, Girardi, Leonard N, Taggart, David P
Published in Circulation (New York, N.Y.) (31.10.2017)
Published in Circulation (New York, N.Y.) (31.10.2017)
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Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.
Published in Cell reports (Cambridge) (12.06.2014)
Published in Cell reports (Cambridge) (12.06.2014)
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