Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2
Clark, Michael P, Ledeboer, Mark W, Davies, Ioana, Byrn, Randal A, Jones, Steven M, Perola, Emanuele, Tsai, Alice, Jacobs, Marc, Nti-Addae, Kwame, Bandarage, Upul K, Boyd, Michael J, Bethiel, Randy S, Court, John J, Deng, Hongbo, Duffy, John P, Dorsch, Warren A, Farmer, Luc J, Gao, Huai, Gu, Wenxin, Jackson, Katrina, Jacobs, Dylan H, Kennedy, Joseph M, Ledford, Brian, Liang, Jianglin, Maltais, François, Murcko, Mark, Wang, Tiansheng, Wannamaker, M. Woods, Bennett, Hamilton B, Leeman, Joshua R, McNeil, Colleen, Taylor, William P, Memmott, Christine, Jiang, Min, Rijnbrand, Rene, Bral, Christopher, Germann, Ursula, Nezami, Azin, Zhang, Yuegang, Salituro, Francesco G, Bennani, Youssef L, Charifson, Paul S
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
Robust Strategy for Hit-to-Lead Discovery: NMR for SAR
Larda, Sacha T., Ayotte, Yann, Denk, Maria M., Coote, Paul, Heffron, Gregory, Bendahan, David, Shahout, Fatma, Girard, Nicolas, Iddir, Mustapha, Bouchard, Patricia, Bilodeau, Francois, Woo, Simon, Farmer, Luc J., LaPlante, Steven R.
Published in Journal of medicinal chemistry (12.10.2023)
Published in Journal of medicinal chemistry (12.10.2023)
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Journal Article
Discovery of Novel, Orally Bioavailable β‑Amino Acid Azaindole Inhibitors of Influenza PB2
Farmer, Luc J., Clark, Michael P., Boyd, Michael J., Perola, Emanuele, Jones, Steven M., Tsai, Alice, Jacobs, Marc D., Bandarage, Upul K., Ledeboer, Mark W., Wang, Tiansheng, Deng, Hongbo, Ledford, Brian, Gu, Wenxin, Duffy, John P., Bethiel, Randy S., Shannon, Dean, Byrn, Randal A., Leeman, Joshua R., Rijnbrand, Rene, Bennett, Hamilton B., O’Brien, Colleen, Memmott, Christine, Nti-Addae, Kwame, Bennani, Youssef L., Charifson, Paul S.
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Journal Article
Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
Farmer, Luc J, Ledeboer, Mark W, Hoock, Thomas, Arnost, Michael J, Bethiel, Randy S, Bennani, Youssef L, Black, James J, Brummel, Christopher L, Chakilam, Ananthsrinivas, Dorsch, Warren A, Fan, Bin, Cochran, John E, Halas, Summer, Harrington, Edmund M, Hogan, James K, Howe, David, Huang, Hui, Jacobs, Dylan H, Laitinen, Leena M, Liao, Shengkai, Mahajan, Sudipta, Marone, Valerie, Martinez-Botella, Gabriel, McCarthy, Pamela, Messersmith, David, Namchuk, Mark, Oh, Luke, Penney, Marina S, Pierce, Albert C, Raybuck, Scott A, Rugg, Arthur, Salituro, Francesco G, Saxena, Kumkum, Shannon, Dean, Shlyakter, Dina, Swenson, Lora, Tian, Shi-Kai, Town, Christopher, Wang, Jian, Wang, Tiansheng, Wannamaker, M. Woods, Winquist, Raymond J, Zuccola, Harmon J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)
FARMER, Luc J, BEMIS, Guy, TER HAAR, Ernst, JIAN WANG, ZHAVERI, Darshana, SALITURO, Francesco G, BRITT, Shawn D, COCHRAN, John, CONNORS, Martin, HARRINGTON, Edmund M, HOOCK, Thomas, MARKLAND, William, NANTHAKUMAR, Suganthini, TASLIMI, Paul
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P 2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Journal Article
Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines
Hamann, Lawrence G, Higuchi, Robert I, Zhi, Lin, Edwards, James P, Wang, Xiao-Ning, Marschke, Keith B, Kong, James W, Farmer, Luc J, Jones, Todd K
Published in Journal of medicinal chemistry (12.02.1998)
Published in Journal of medicinal chemistry (12.02.1998)
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Journal Article
Aza-retinoids as novel retinoid X receptor-specific agonists
Farmer, Luc J., Marron, Kristen S., Canan Koch, Stacie S., Hwang, C.K., Kallel, E Adam, Zhi, Lin, Nadzan, Alex M., Robertson, Dave W., Bennani, Youssef L.
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid
Farmer, Luc J., Zhi, Lin, Jeong, Susan, Lamph, William W., Osburn, Deborah L., Croston, Glenn, Flatten, Karen S., Heyman, Rich A., Nadzan, Alex M.
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
Published in Bioorganic & medicinal chemistry letters (20.01.2003)
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Journal Article
VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease
Mahajan, Sudipta, Hogan, James K, Shlyakhter, Dina, Oh, Luke, Salituro, Francesco G, Farmer, Luc, Hoock, Thomas C
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2015)
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Journal Article
Synthesis and Biological Activity of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Cyclocymopol Monomethyl Ether
Hamann, Lawrence G, Farmer, Luc J, Johnson, Michael G, Bender, Steven L, Mais, Dale E, Wang, Ming-Wei, Crombie, Diane, Goldman, Mark E, Jones, Todd K
Published in Journal of medicinal chemistry (26.04.1996)
Published in Journal of medicinal chemistry (26.04.1996)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants
Perni, Robert B, Farmer, Luc J, Cottrell, Kevin M, Court, John J, Courtney, Lawrence F, Deininger, David D, Gates, Cynthia A, Harbeson, Scott L, Kim, Joseph L, Lin, Chao, Lin, Kai, Luong, Yu-Ping, Maxwell, John P, Murcko, Mark A, Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C, Tung, Roger D, Van Drie, John H, Wilson, Keith, Thomson, John A
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
Published in Bioorganic & medicinal chemistry letters (01.04.2004)
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Journal Article
Inhibitors of hepatitis C virus NS3·4A protease 2. Warhead SAR and optimization
Perni, Robert B., Pitlik, Janos, Britt, Shawn D., Court, John J., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Levin, Rhonda B., Lin, Chao, Lin, Kai, Moon, Young-Choon, Luong, Yu-Ping, O'Malley, Ethan T., Rao, B.Govinda, Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
Published in Bioorganic & medicinal chemistry letters (22.03.2004)
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Journal Article
Discovery and Development of Telaprevir
Grillot, Anne‐Laure, Farmer, Luc J, Rao, B. Govinda, Taylor, William P, Weisberg, Ilan S, Jacobson, Ira M, Perni, Robert B, Kwong, Ann D
Published in Antiviral Drugs (08.08.2011)
Published in Antiviral Drugs (08.08.2011)
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Book Chapter
Inhibitors of hepatitis C virus NS3·4A protease 1. Non-Charged tetrapeptide variants
Perni, Robert B., Britt, Shawn D., Court, John C., Courtney, Lawrence F., Deininger, David D., Farmer, Luc J., Gates, Cynthia A., Harbeson, Scott L., Kim, Joseph L., Landro, James A., Levin, Rhonda B., Luong, Yu-Ping, O'Malley, Ethan T., Pitlik, Janos, Rao, B.Govinda, Schairer, Wayne C., Thomson, John A., Tung, Roger D., Van Drie, John H., Wei, Yunyi
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
Published in Bioorganic & medicinal chemistry letters (17.11.2003)
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Journal Article
RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
AYOTTE, Yann, FARAHANI, Majid, WOO, Simon, BENDAHAN, David, FARMER, Luc, DENK, Maria, LAPLANTE, Steven, ALAPOUR, Saba, IDDIR, Mustapha, LARDA, Sacha Thierry
Year of Publication 21.08.2024
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Year of Publication 21.08.2024
Patent
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1 H)-pyrrolidino[3,2- g]quinolinone
Edwards, James P., West, Sarah J., Pooley, Charlotte L.F., Marschke, Keith B., Farmer, Luc J., Jones, Todd K.
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
Published in Bioorganic & medicinal chemistry letters (07.04.1998)
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Journal Article
RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
AYOTTE, Yann, FARAHANI, Majid, WOO, Simon, BENDAHAN, David, FARMER, Luc, DENK, Maria, LAPLANTE, Steven, ALAPOUR, Saba, IDDIR, Mustapha, LARDA, Sacha Thierry
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent
RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF
LAPLANTE, STEVEN, ALAPOUR, SABA, IDDIR, MUSTAPHA, LARDA, SACHA THIERRY, FARMER, LUC, AYOTTE, YANN, WOO, SIMON, FARAHANI, MAJID, BENDAHAN, DAVID, DENK, MARIA
Year of Publication 20.04.2023
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Year of Publication 20.04.2023
Patent