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Copper(I)-Catalyzed Nitrile-Addition/ N -Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6 H -indolo[3,2- c ]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

Copper(I)-Catalyzed Nitrile-Addition/ N -Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6 H -indolo[3,2- c ]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

by Hsueh, Wen-Yun, Lee, Ying-Shuan E, Huang, Min-Sian, Lai, Chin-Hung, Gao, Yu-Sheng, Lin, Jo-Chu, Chen, Yu-Fen, Chang, Chih-Lin, Chou, Shan-Yen, Chen, Shyh-Fong, Lu, Yann-Yu, Chang, Lien-Hsiang, Lin, Shu Fu, Lin, Yu-Hsiang, Hsu, Pi-Chen, Wei, Win-Yin, Huang, Ya-Chi, Kao, Yi-Feng, Teng, Li-Wei, Liu, Hung-Huang, Chen, Ying-Chou, Yuan, Ta-Tung, Chan, Ya-Wen, Huang, Po-Hsun, Chao, Yu-Ting, Huang, Shin-Yi, Jian, Bo-Han, Huang, Hsin-Yi, Yang, Sheng-Chuan, Lo, Tzu-Hao, Huang, Guan-Ru, Wang, Shao-Yun, Lin, Her-Sheng, Chuang, Shih-Hsien, Huang, Jiann-Jyh
Published in Journal of medicinal chemistry (11.02.2021)

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Journal Article

Synthesis of selenophene derivatives as novel CHK1 inhibitors

Synthesis of selenophene derivatives as novel CHK1 inhibitors

by Hong, Pao-Chiung, Chen, Li-Jung, Lai, Tzu-Yun, Yang, Huei-Yu, Chiang, Shih-Jan, Lu, Yann-Yu, Tsai, Ping-Kuei, Hsu, Hung-Yi, Wei, Win-Yin, Liao, Chu-Bin
Published in Bioorganic & medicinal chemistry letters (01.09.2010)

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Journal Article

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro‑6H‑indolo[3,2‑c]quinolin-6-ones as Potent Topoisomerase‑I Inhibitors

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro‑6H‑indolo[3,2‑c]quinolin-6-ones as Potent Topoisomerase‑I Inhibitors

by Hsueh, Wen-Yun, Lee, Ying-Shuan E, Huang, Min-Sian, Lai, Chin-Hung, Gao, Yu-Sheng, Lin, Jo-Chu, Chen, Yu-Fen, Chang, Chih-Lin, Chou, Shan-Yen, Chen, Shyh-Fong, Lu, Yann-Yu, Chang, Lien-Hsiang, Lin, Shu Fu, Lin, Yu-Hsiang, Hsu, Pi-Chen, Wei, Win-Yin, Huang, Ya-Chi, Kao, Yi-Feng, Teng, Li-Wei, Liu, Hung-Huang, Chen, Ying-Chou, Yuan, Ta-Tung, Chan, Ya-Wen, Huang, Po-Hsun, Chao, Yu-Ting, Huang, Shin-Yi, Jian, Bo-Han, Huang, Hsin-Yi, Yang, Sheng-Chuan, Lo, Tzu-Hao, Huang, Guan-Ru, Wang, Shao-Yun, Lin, Her-Sheng, Chuang, Shih-Hsien, Huang, Jiann-Jyh
Published in Journal of medicinal chemistry (11.02.2021)

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Journal Article

HMDS-promotedin situ amidation reactions of car☐ylic acids and amines

HMDS-promotedin situ amidation reactions of car☐ylic acids and amines

by Chou, Wen-Chih, Chou, Ming-Chen, Lu, Yann-Yu, Chen, Shyh-Fong
Published in Tetrahedron letters (01.04.1999)

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Journal Article

HMDS-promoted in situ amidation reactions of carboxylic acids and amines

HMDS-promoted in situ amidation reactions of carboxylic acids and amines

by Chou, WC, Chou, MC, Lu, YY, Chen, SF
Published in Tetrahedron letters (23.04.1999)

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Journal Article

Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof

Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof

by Lu, Yann-Yu, Liu, Chia-Wei, Yang, Ju-Ying, Hsieh, Seline, Lee, Ying-Shuan, Kuo, Mann-Yan
Year of Publication 06.10.2020

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Patent

HMDS-promoted in situ amidation reactions of car☐ylic acids and amines

HMDS-promoted in situ amidation reactions of car☐ylic acids and amines

by Chou, Wen-Chih, Chou, Ming-Chen, Lu, Yann-Yu, Chen, Shyh-Fong
Published in Tetrahedron letters (1999)

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Journal Article

Pyrimidine compounds as mTOR and PI3K inhibitors

Pyrimidine compounds as mTOR and PI3K inhibitors

by Tsai Ping-Kuei, Kuo Mann-Yan, Huang Yi-Ting, Chen Li Jung, Lee Ying-Shuan, Lu Yann Yu, Chen Paonien, Hsu Hung-Yi
Year of Publication 31.10.2017

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by LU, Yann-Yu, HSIEH, Seline, KUO, Mann-Yan, LEE, Ying-Shuan, YANG, Ju-Ying, LIU, Chia-Wei
Year of Publication 04.01.2023

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by LU, Yann-Yu, HSIEH, Seline, KUO, Mann-Yan, LEE, Ying-Shuan, YANG, Ju-Ying, LIU, Chia-Wei
Year of Publication 19.08.2020

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Patent

COMPOUNDS FOR MUTANT RAS PROTEIN DEGRADATION

COMPOUNDS FOR MUTANT RAS PROTEIN DEGRADATION

by LU, Yann-Yu, CHUANG, Shih-Hsien, HOU, Mei-Ling, LIN, Yu-Shiang, HSU, Hui-Jan, LAI, Chun-Liang, LIANG, Chen-Hsien, LAILEE, Ying-Shuan, LIN, Her-Sheng
Year of Publication 04.11.2021

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by LU, Yann-Yu, HSIEH, Seline, KUO, Mann-Yan, LEE, Ying-Shuan, YANG, Ju-Ying, LIU, Chia-Wei
Year of Publication 02.10.2019

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by KUO, MANN-YAN, LEE, YING-SHUAN, YANG, JU-YING, LIU, CHIA-WEI, HSIEH, SELINE, LU, YANN-YU
Year of Publication 12.03.2020

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by LU, Yann-Yu, HSIEH, Seline, KUO, Mann-Yan, LEE, Ying-Shuan, YANG, Ju-Ying, LIU, Chia-Wei
Year of Publication 31.05.2018

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Patent

Compounds for mutant RAS protein degradation

Compounds for mutant RAS protein degradation

by CHUANG, SHIH-HSIEN, LAI, CHUN-LIANG, LIN, YU-SHIANG, LIN, HER-SHENG, HOU, MEI-LING, LIANG, CHEN-HSIEN, HSU, HUI-JAN, LU, YANN-YU, LAILEE, YING-SHUAN
Year of Publication 16.02.2022

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Patent

Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof

Hetroarylamine compounds for modulating the hedgehog pathway and preparing method and uses thereof

by KUO, MANN-YAN, LEE, YING-SHUAN, YANG, JU-YING, LIU, CHIA-WEI, HSIEH, SELINE, LU, YANN-YU
Year of Publication 01.03.2021

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Patent

NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS

NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS

by CHEN, PAONIEN, KUO, MANN-YAN, LEE, YING-SHUAN, TSAI, PING-KUEI, HSU, HUNG-YI, CHEN, LI JUNG, HUANG, YI-TING, LU, YANN YU
Year of Publication 19.10.2016

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Patent

NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS

NOVEL PYRIMIDINE COMPOUNDS AS mTOR AND PI3K INHIBITORS

by CHEN LI JUNG, HSU HUNG-YI, HUANG YI-TING, TSAI PING-KUEI, LU YANN YU, CHEN PAONIEN, KUO MANN-YAN, LEE YING-SHUAN
Year of Publication 19.05.2016

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Patent

Pyrimidine compounds as mTOR and PI3K inhibitors

Pyrimidine compounds as mTOR and PI3K inhibitors

by CHEN LI JUNG, HSU HUNG-YI, HUANG YI-TING, TSAI PING-KUEI, LU YANN YU, CHEN PAONIEN, KUO MANN-YAN, LEE YING-SHUAN
Year of Publication 19.04.2016

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Patent

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF

by LU YANN-YU, KUO MANN-YAN, YANG JU-YING, LIU CHIA-WEI, HSIEH SELINE, LEE YING-SHUAN
Year of Publication 16.08.2019

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Patent