Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity
Siegal, Deborah M, Curnutte, John T, Connolly, Stuart J, Lu, Genmin, Conley, Pamela B, Wiens, Brian L, Mathur, Vandana S, Castillo, Janice, Bronson, Michele D, Leeds, Janet M, Mar, Florie A, Gold, Alex, Crowther, Mark A
Published in The New England journal of medicine (17.12.2015)
Published in The New England journal of medicine (17.12.2015)
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Journal Article
Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors
Connolly, Stuart J, Crowther, Mark, Eikelboom, John W, Gibson, C. Michael, Curnutte, John T, Lawrence, John H, Yue, Patrick, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Demchuk, Andrew M, Pallin, Daniel J, Concha, Mauricio, Goodman, Shelly, Leeds, Janet, Souza, Sonia, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Ahmad, Sadia, Nakamya, Juliet, Milling, Truman J
Published in The New England journal of medicine (04.04.2019)
Published in The New England journal of medicine (04.04.2019)
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Journal Article
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
Lu, Genmin, DeGuzman, Francis R, Hollenbach, Stanley J, Karbarz, Mark J, Abe, Keith, Lee, Gail, Luan, Peng, Hutchaleelaha, Athiwat, Inagaki, Mayuko, Conley, Pamela B, Phillips, David R, Sinha, Uma
Published in Nature medicine (01.04.2013)
Published in Nature medicine (01.04.2013)
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Journal Article
Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors
Connolly, Stuart J, Milling, Truman J, Eikelboom, John W, Gibson, C. Michael, Curnutte, John T, Gold, Alex, Bronson, Michele D, Lu, Genmin, Conley, Pamela B, Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T, Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L, Siegal, Deborah M, Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W. Ting, Crowther, Mark
Published in The New England journal of medicine (22.09.2016)
Published in The New England journal of medicine (22.09.2016)
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Journal Article
Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model
Lu, Genmin, Pine, Polly, Leeds, Janet M, DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J, Curnutte, John T, Conley, Pamela B
Published in PloS one (28.03.2018)
Published in PloS one (28.03.2018)
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Journal Article
Comparison of reversal activity and mechanism of action of UHRA, andexanet, and PER977 on heparin and oral FXa inhibitors
Kalathottukaren, Manu T., Creagh, A. Louise, Abbina, Srinivas, Lu, Genmin, Karbarz, Mark J., Pandey, Anjali, Conley, Pamela B., Kizhakkedathu, Jayachandran N., Haynes, Charles
Published in Blood advances (28.08.2018)
Published in Blood advances (28.08.2018)
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Journal Article
Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa
Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark
Published in Blood advances (26.09.2017)
Published in Blood advances (26.09.2017)
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Journal Article
Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model
Pine, Polly, Lu, Genmin, Canivel, Deogracias, Pratikhya, Pratikhya, DeGuzman, Francis, Karbarz, Mark, Takeda, Kentaro, Malinowski, John, Leeds, Janet M., Curnutte, John T., Conley, Pamela B.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase
Buddai, Sai K., Layzer, Juliana M., Lu, Genmin, Rusconi, Christopher P., Sullenger, Bruce A., Monroe, Dougald M., Krishnaswamy, Sriram
Published in The Journal of biological chemistry (19.02.2010)
Published in The Journal of biological chemistry (19.02.2010)
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Journal Article
Abstract 10: Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Pharmacokinetic and Pharmacodynamic Study of PRT064445, a Universal Antidote for Factor Xa Inhibitors
Crowther, Mark, Kitt, Michael, McClure, Matthew, Sinha, Uma, Lu, Genmin, Karbarz, Mark, Hutchaleelaha, Athiwat, Barron, Lee, Mathur, Vandana, Curnutte, John
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2013)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2013)
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Journal Article
Recombinant Antidote for Reversal of Anticoagulation by Factor Xa Inhibitors
Lu, Genmin, DeGuzman, Francis R., Lakhotia, Sanjay, Hollenbach, Stanley J, Phillips, David R, Sinha, Uma
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Journal Article
Formation of Factors IXa and Xa by the Extrinsic Pathway
Lu, Genmin, Broze, George J., Krishnaswamy, Sriram
Published in The Journal of biological chemistry (23.04.2004)
Published in The Journal of biological chemistry (23.04.2004)
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Journal Article
Andexanet Alfa for Specific Anticoagulation Reversal in Patients with Acute Bleeding during Treatment with Edoxaban
Benz, Alexander P., Xu, Lizhen, Eikelboom, John W., Middeldorp, Saskia, Milling, Truman J., Crowther, Mark, Yue, Patrick, Conley, Pamela, Lu, Genmin, Connolly, Stuart J.
Published in Thrombosis and haemostasis (01.06.2022)
Published in Thrombosis and haemostasis (01.06.2022)
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Journal Article
Validation of a Modified Anti-FXa Assay on STA-Compact Analyzer for Measuring FXa Inhibitor Levels in the Presence of Andexanet Alfa
Cardenas, Juan, Kotha, Jayaprakash, Lu, Genmin, Conley, Pamela B., Bourdin, Matthieu, Herve, Tristan, Jennings, Lisa K.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Modified Anti-FXa Assays for Measuring the Residual Activity of Apixaban and Rivaroxaban in Andexanet Alfa-Containing Samples on the ACL TOP Family® Coagulation Analyzers
Khan, Anuja, Shishko, Krisjela, Arcidiacono, Sam, Bui, Khanh, Lu, Genmin, Conley, Pamela B., Winkler, Anne
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Prothrombin Complex Concentrates (PCCs) Have Limited Effect on TF-Initiated Thrombin Generation in FXa Inhibitor-Anticoagulated Plasma: In Vitro Comparison between Direct Reversal By Andexanet Alfa and “Work Around” By PCCs
Lu, Genmin, Lin, Joyce P., Bui, Khanh, Curnutte, John T., Conley, Pamela B.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
Analytical Performance of Modified Anti-FXa Assays for Andexanet Alfa-Containing Plasma Samples on the ACL TOP/TOP 50 Coagulation Analyzers
Khan, Anuja, Shishko, Krisjela, Marett, Ryan, Arcidiacono, Sam, Nguyen, Vy, Lu, Genmin, Bui, Khanh, Conley, Pamela B., Winkler, Anne
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Abstract P3: Andexanet Alfa for Acute Bleeding During Treatment With Edoxaban
Benz, Alexander P, Xu, Lizhen, Eikelboom, John W, Middeldorp, Saskia, Milling, Truman J, Crowther, Mark, Yue, Patrick, Conley, Pamela, Lu, Genmin, Connolly, Stuart J
Published in Stroke (1970) (01.03.2021)
Published in Stroke (1970) (01.03.2021)
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Journal Article
Measuring residual anti‐Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa
Bourdin, Matthieu, Perrotin, Delphine, Mathieu, Olivier, Herve, Tristan, Depasse, François, Lu, Genmin, Conley, Pamela B., Contant, Geneviève
Published in International journal of laboratory hematology (01.08.2021)
Published in International journal of laboratory hematology (01.08.2021)
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Journal Article