Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin
Morgan, Bradley P, Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W, Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M, Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A, Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I, Morgans, David J
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
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Journal Article
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Published in Science (American Association for the Advancement of Science) (18.03.2011)
Published in Science (American Association for the Advancement of Science) (18.03.2011)
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Journal Article
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function
Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Journal Article
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Published in Nature medicine (01.03.2012)
Published in Nature medicine (01.03.2012)
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Journal Article
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application
Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (22.11.2016)
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Journal Article
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase
Hanessian, Stephen, Lu, Pu-Ping, Sancéau, Jean-Yves, Chemla, Philippe, Gohda, Keigo, Fonne-Pfister, Raymonde, Prade, Lars, Cowan-Jacob, Sandra W.
Published in Angewandte Chemie International Edition (02.11.1999)
Published in Angewandte Chemie International Edition (02.11.1999)
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Journal Article
One-Step, Stereocontrolled Synthesis of Glycosyl 1-Phosphates, Uridine-5‘-diphosphogalactose, and Uridine-5‘-diphosphoglucose from Unprotected Glycosyl Donors
Hanessian, Stephen, Lu, Pu-Ping, Ishida, Hideki
Published in Journal of the American Chemical Society (30.12.1998)
Published in Journal of the American Chemical Society (30.12.1998)
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Journal Article
Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator
Collibee, Scott E, Bergnes, Gustave, Muci, Alexander, Browne, William F, Garard, Marc, Hinken, Aaron C, Russell, Alan J, Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H, Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I, Morgans, David J, Morgan, Bradley P
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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Journal Article
Synthesis and evaluation of eight aminodeoxy trisaccharide inhibitors for N-acetylglucosaminyltransferase-V
Lu, Pu-Ping, Hindsgaul, Ole, Li, Hong, Palcic, Monica M.
Published in Carbohydrate research (26.09.1997)
Published in Carbohydrate research (26.09.1997)
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Journal Article
A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit
Cushing, Timothy D., Baichwal, Vijay, Berry, Karen, Billedeau, Roland, Bordunov, Viola, Broka, Chris, Cardozo, Mario, Cheng, Peng, Clark, David, Dalrymple, Stacie, DeGraffenreid, Michael, Gill, Adrian, Hao, Xiaolin, Hawley, Ronald C., He, Xiao, Jaen, Juan C., Labadie, Sharada S., Labelle, Marc, Lehel, Csaba, Lu, Pu-Ping, McIntosh, Joel, Miao, Shichang, Parast, Camran, Shin, Youngsook, Sjogren, Eric B., Smith, Marie-Louise, Talamas, Francisco X., Tonn, George, Walker, Keith M., Walker, Nigel P.C., Wesche, Holger, Whitehead, Chris, Wright, Matt, Browner, Michelle F.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs
Cushing, Timothy D., Baichwal, Vijay, Berry, Karen, Billedeau, Roland, Bordunov, Viola, Broka, Chris, Browner, Michelle F., Cardozo, Mario, Cheng, Peng, Clark, David, Dalrymple, Stacie, DeGraffenreid, Michael, Gill, Adrian, Hao, Xiaolin, Hawley, Ronald C., He, Xiao, Labadie, Sharada S., Labelle, Marc, Lehel, Csaba, Lu, Pu-Ping, McIntosh, Joel, Miao, Shichang, Parast, Camran, Shin, Youngsook, Sjogren, Eric B., Smith, Marie-Louise, Talamas, Francisco X., Tonn, George, Walker, Keith M., Walker, Nigel P.C., Wesche, Holger, Whitehead, Chris, Wright, Matt, Jaen, Juan C.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
New synthetic trisaccharide inhibitors for N-acetylglucosaminyltransferase-V
Lu, Pu-Ping, Hindsgaul, Ole, Compston, Catharine A., Palcic, Monica M.
Published in Bioorganic & medicinal chemistry (01.11.1996)
Published in Bioorganic & medicinal chemistry (01.11.1996)
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Journal Article
Deoxyscytalidin and Lignicol: New Metabolites from Scytalidium Species
Ayer, William A, Lu, Pu-ping, Orszanska, Helena, Sigler, Lynne
Published in Journal of natural products (Washington, D.C.) (01.10.1993)
Published in Journal of natural products (Washington, D.C.) (01.10.1993)
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Journal Article
Synthesis and evaluation of thio-trisaccharides as acceptors for N-acetylglucos-aminyltransferase-V
Lu, Pu-Ping, Hindsgaul, Ole, Li, Hong, Palcic, Monica M
Published in Canadian journal of chemistry (01.06.1997)
Published in Canadian journal of chemistry (01.06.1997)
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Journal Article
Bicyclic 1,4-diazepanones and therapeutic uses thereof
Yamaki, Susumu, Katoh, Naoto, Kuriwaki, Ikumi, Koizumi, Yuka, Wang, Wenyue, Collibee, Scott, Yamasaki, Makoto, Makino, Takuya, Morgan, Bradley P, Tsuchiya, Kazuyuki, Sekioka, Ryuichi, Kurosaki, Toshio, Honjo, Eriko, Evans, Chris, Lu, Pu-Ping
Year of Publication 14.05.2024
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Year of Publication 14.05.2024
Patent
Bicyclic 1,4-diazepanones and therapeutic uses thereof
Takuya MAKINO, Kazuyuki TSUCHIYA, Wenyue WANG, Toshio KUROSAKI, Ryuichi SEKIOKA, Scott COLLIBEE, Naoto KATOH, Bradley P. MORGAN, Chris EVANS, Eriko HONJO, Pu-Ping LU, Ikumi KURIWAKI, Susumu YAMAKI, Makoto YAMASAKI, Yuka KOIZUMI
Year of Publication 01.07.2023
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Year of Publication 01.07.2023
Patent
Amino-pyrimidine skeletal muscle modulators
Qian, Xiangping, Morgan, Bradley P, Yang, Zhe, Bergnes, Gustave, Warrington, Jeffrey, Collibee, Scott, Lu, Pu-Ping, Romero, Antonio, Chuang, Chihyuan, Muci, Alex R
Year of Publication 28.06.2022
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Year of Publication 28.06.2022
Patent
COMPOUNDS, COMPOSITIONS AND METHODS
Muci, Alex, Lu, Pu-Ping, Tochimoto, Todd, Morgan, Bradley Paul, Kraynack, Erica Anne, Morgans, JR., David J
Year of Publication 01.07.2021
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Year of Publication 01.07.2021
Patent