Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
Iwamoto, Naoki, Butler, David C D, Svrzikapa, Nenad, Mohapatra, Susovan, Zlatev, Ivan, Sah, Dinah W Y, Meena, Standley, Stephany M, Lu, Genliang, Apponi, Luciano H, Frank-Kamenetsky, Maria, Zhang, Jason Jingxin, Vargeese, Chandra, Verdine, Gregory L
Published in Nature biotechnology (01.09.2017)
Published in Nature biotechnology (01.09.2017)
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Journal Article
Polymer-Supported Palladacycles: Efficient Reagents for Synthesis of Benzopyrans with Palladium Recovery. Relationship among Resin Loading, Pd:P Ratio, and Reactivity of Immobilized Palladacycles
Hershberger, John C, Zhang, Lei, Lu, Genliang, Malinakova, Helena C
Published in Journal of organic chemistry (06.01.2006)
Published in Journal of organic chemistry (06.01.2006)
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Journal Article
Universal Peptidomimetics
Ko, Eunhwa, Liu, Jing, Perez, Lisa M, Lu, Genliang, Schaefer, Amber, Burgess, Kevin
Published in Journal of the American Chemical Society (26.01.2011)
Published in Journal of the American Chemical Society (26.01.2011)
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Journal Article
Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides
Monian, Prashant, Shivalila, Chikdu, Lu, Genliang, Shimizu, Mamoru, Boulay, David, Bussow, Karley, Byrne, Michael, Bezigian, Adam, Chatterjee, Arindom, Chew, David, Desai, Jigar, Favaloro, Frank, Godfrey, Jack, Hoss, Andrew, Iwamoto, Naoki, Kawamoto, Tomomi, Kumarasamy, Jayakanthan, Lamattina, Anthony, Lindsey, Amber, Liu, Fangjun, Looby, Richard, Marappan, Subramanian, Metterville, Jake, Murphy, Ronelle, Rossi, Jeff, Pu, Tom, Bhattarai, Bijay, Standley, Stephany, Tripathi, Snehlata, Yang, Hailin, Yin, Yuan, Yu, Hui, Zhou, Cong, Apponi, Luciano H, Kandasamy, Pachamuthu, Vargeese, Chandra
Published in Nature biotechnology (01.07.2022)
Published in Nature biotechnology (01.07.2022)
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Journal Article
Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference
Liu, Wei, Iwamoto, Naoki, Marappan, Subramanian, Luu, Khoa, Tripathi, Snehlata, Purcell-Estabrook, Erin, Shelke, Juili Dilip, Shah, Himali, Lamattina, Anthony, Pan, Qianli, Schrand, Brett, Favaloro, Frank, Bedekar, Mugdha, Chatterjee, Arindom, Desai, Jigar, Kawamoto, Tomomi, Lu, Genliang, Metterville, Jake, Samaraweera, Milinda, Prakasha, Priyanka Shiva, Yang, Hailin, Yin, Yuan, Yu, Hui, Giangrande, Paloma H, Byrne, Michael, Kandasamy, Pachamuthu, Vargeese, Chandra
Published in Nucleic acids research (22.05.2023)
Published in Nucleic acids research (22.05.2023)
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Journal Article
Synthesis and SAR of Tc-99m/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates
Lu, Genliang, Maresca, Kevin P., Hillier, Shawn M., Zimmerman, Craig N., Eckelman, William C., Joyal, John L., Babich, John W.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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Journal Article
Rational design of base, sugar and backbone modifications improves ADAR-mediated RNA editing
Lu, Genliang, Shivalila, Chikdu, Monian, Prashant, Yu, Hui, Harding, Ian, Briem, Stearne, Byrne, Michael, Faraone, Alyse, Friend, Stephen, Huth, Olivia, Iwamoto, Naoki, Kawamoto, Tomomi, Kumarasamy, Jayakanthan, Lamattina, Anthony, Longo, Kenneth, McCarthy, Leah, McGlynn, Andrew, Molski, Allison, Pan, Qianli, Pu, Tom, Purcell-Estabrook, Erin, Rossi, Jeff, Standley, Stephany, Thomas, Carina, Walen, Alexandra, Yang, Hailin, Kandasamy, Pachamuthu, Vargeese, Chandra
Published in Nucleic acids research (23.09.2024)
Published in Nucleic acids research (23.09.2024)
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Journal Article
Control of backbone chemistry and chirality boost oligonucleotide splice switching activity
Kandasamy, Pachamuthu, McClorey, Graham, Shimizu, Mamoru, Kothari, Nayantara, Alam, Rowshon, Iwamoto, Naoki, Kumarasamy, Jayakanthan, Bommineni, Gopal R, Bezigian, Adam, Chivatakarn, Onanong, Butler, David C D, Byrne, Michael, Chwalenia, Katarzyna, Davies, Kay E, Desai, Jigar, Shelke, Juili Dilip, Durbin, Ann F, Ellerington, Ruth, Edwards, Ben, Godfrey, Jack, Hoss, Andrew, Liu, Fangjun, Longo, Kenneth, Lu, Genliang, Marappan, Subramanian, Oieni, Jacopo, Paik, Ik-Hyeon, Estabrook, Erin Purcell, Shivalila, Chikdu, Tischbein, Maeve, Kawamoto, Tomomi, Rinaldi, Carlo, Rajão-Saraiva, Joana, Tripathi, Snehlata, Yang, Hailin, Yin, Yuan, Zhao, Xiansi, Zhou, Cong, Zhang, Jason, Apponi, Luciano, Wood, Matthew J A, Vargeese, Chandra
Published in Nucleic acids research (10.06.2022)
Published in Nucleic acids research (10.06.2022)
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Journal Article
FRI-151 RNA editing for the treatment of Alpha-1 antitrypsin deficiency
Monian, Prashant, Lu, Genliang, Shivalila, Chikdu, Bowman, Keith, Bylsma, Marissa, Byrne, Michael, Cannon, Megan, Desai, Jigar, Faraone, Alyse, Favaloro, Frank, Ghosh, Anamitra, Godfrey, Jack, Hernandez, Nidia, Huth, Olivia, Iwamoto, Naoki, Kawamoto, Tomomi, Kumarasamy, Jayakanthan, Kandasamy, Pachamuthu, Lamattina, Anthony, Lindsey, Amber, Liu, Fangjun, Looby, Richard, Luu, Khoa, Metterville, Jake, Paik, Ik-Hyeon, Pan, Qianli, Purcell-Estabrook, Erin, Rheinhardt, Jeanette, Shimizu, Mamoru, Singh, Kuldeep, Standley, Stephany, Thomas, Carina, Tripathi, Snehlata, Yang, Hailin, Yordanoff, Ryan, Yin, Benny, Yu, Hui, Caracta, Cynthia, Narayanan, Padma, Giangrande, Paloma, Vargeese, Chandra
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Journal Article
Synthesis and SAR of Novel Re/Tc-99m-Labeled Benzenesulfonamide Carbonic Anhydrase IX Inhibitors for Molecular Imaging of Tumor Hypoxia
Lu, Genliang, Hillier, Shawn M., Maresca, Kevin P., Zimmerman, Craig N., Eckelman, William C., Joyal, John L., Babich, John W.
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Journal Article
Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics
Deprey, Kirsten, Batistatou, Nefeli, Debets, Marjoke F, Godfrey, Jack, VanderWall, Kirstin B, Miles, Rebecca R, Shehaj, Livia, Guo, Jiaxing, Andreucci, Amy, Kandasamy, Pachamuthu, Lu, Genliang, Shimizu, Mamoru, Vargeese, Chandra, Kritzer, Joshua A
Published in ACS chemical biology (18.02.2022)
Published in ACS chemical biology (18.02.2022)
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Journal Article
Sa1465 - The Pharmacological Properties of APOC3 Antisense Oligonucleotides are Enhanced by Control of Stereochemistry
Apponi, Luciano, Iwamoto, Naoki, Frank-Kamenetsky, Maria, Yang, Hailin, Braun, Maurine, Shah, Anee, Yin, Yuan, Butler, David, Lu, Genliang, Menon, Sethu, Standley, Stephany, Aduda, Vincent, Bowman, Keith, Longo, Kenneth, Pittet, Lynnelle, Zhang, Jason, Zhong, Zhong, Vargeese, Chandra
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2018)
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Journal Article
Small molecule inhibitors of PSMA incorporating technetium-99m for imaging prostate cancer: Effects of chelate design on pharmacokinetics
Maresca, Kevin P., Hillier, Shawn M., Lu, Genliang, Marquis, John C., Zimmerman, Craig N., Eckelman, William C., Joyal, John L., Babich, John W.
Published in Inorganica Chimica Acta (01.07.2012)
Published in Inorganica Chimica Acta (01.07.2012)
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Journal Article
Novel Polar Single Amino Acid Chelates for Technetium-99m Tricarbonyl-Based Radiopharmaceuticals with Enhanced Renal Clearance: Application to Octreotide
Maresca, Kevin P, Marquis, John C, Hillier, Shawn M, Lu, Genliang, Femia, Frank J, Zimmerman, Craig N, Eckelman, William C, Joyal, John L, Babich, John W
Published in Bioconjugate chemistry (16.06.2010)
Published in Bioconjugate chemistry (16.06.2010)
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Journal Article
Synthesis and SAR of Novel Re/ 99m Tc-Labeled Benzenesulfonamide Carbonic Anhydrase IX Inhibitors for Molecular Imaging of Tumor Hypoxia
Lu, Genliang, Hillier, Shawn M., Maresca, Kevin P., Zimmerman, Craig N., Eckelman, William C., Joyal, John L., Babich, John W.
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Journal Article
Synthesis and SAR of Novel Re/99mTc-Labeled Benzenesulfonamide Carbonic Anhydrase IX Inhibitors for Molecular Imaging of Tumor Hypoxia
Lu, Genliang, Hillier, Shawn M, Maresca, Kevin P, Zimmerman, Craig N, Eckelman, William C, Joyal, John L, Babich, John W
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Journal Article