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Anticancer Drugs of Lysine Specific Histone Demethylase‑1 (LSD1) Display Variable Inhibition on Nucleosome Substrates
Senanayaka, Dulmi, Zeng, Danyun, Deniz, Emre, Priyankara, Indunil K., Helmbreck, Joceline, Schneider, Owen, Mardikar, Aashay, Uren, Aykut, Reiter, Nicholas J.
Published in Biochemistry (Easton) (04.06.2024)
Published in Biochemistry (Easton) (04.06.2024)
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Inhibition of the histone demethylase LSD1 blocks α-herpesvirus lytic replication and reactivation from latency
Liang, Yu, Vogel, Jodi L, Narayanan, Aarthi, Peng, Hua, Kristie, Thomas M
Published in Nature medicine (01.11.2009)
Published in Nature medicine (01.11.2009)
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Human Histone Demethylase LSD1 Reads the Histone Code
Forneris, Federico, Binda, Claudia, Vanoni, Maria Antonietta, Battaglioli, Elena, Mattevi, Andrea
Published in The Journal of biological chemistry (16.12.2005)
Published in The Journal of biological chemistry (16.12.2005)
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Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes
Hill, James M, Quenelle, Debra C, Cardin, Rhonda D, Vogel, Jodi L, Clement, Christian, Bravo, Fernando J, Foster, Timothy P, Bosch-Marce, Marta, Raja, Priya, Lee, Jennifer S, Bernstein, David I, Krause, Philip R, Knipe, David M, Kristie, Thomas M
Published in Science translational medicine (03.12.2014)
Published in Science translational medicine (03.12.2014)
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Bomedemstat (IMG-7289), an LSD1 Inhibitor, Manages the Signs and Symptoms of Essential Thrombocythemia (ET) While Reducing the Burden of Cells Homozygous for Driver Mutations
Goethert, Joachim R., Gill, Harinder, Palandri, Francesca, Ross, David M., Cochrane, Tara, Larsen, Stephen R., Halpern, Anna B., Shortt, Jake, Rossetti, James M., Liang, James, Marchetti, Monia, Wilson, Andrew J., Innes, Andrew, Hanna, Merit, Stevenson, William S., Vannucchi, Alessandro M., Kleppe, Maria, Natsoulis, Georges, Harrison, Claire N, Rienhoff Jr, Hugh Young
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Anti-tumor activity of CoREST inhibitor, JBI-802 (dual epigenetic modifier of LSD1/HDAC6): An opportunity to treat essential thrombocythemia and MPN/MDS patients with thrombocytosis in ongoing phase 1/2 clinical trial
Dolan, Melda S., Rajagopal, Sridharan, B., Abhijit, Mittal, Deepak, Vazeer, Shawnavaz, Zainuddin, Mohd, Chandru, G., Sadhu, Naveen, Kazmi, Syed
Published in Journal of clinical oncology (01.06.2025)
Published in Journal of clinical oncology (01.06.2025)
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Abstract CT109: A Phase I dose escalation and expansion study of seclidemstat (SP-2577) a first-in class reversible LSD1 inhibitor for patients with relapsed or refractory Ewing sarcoma
Reed, Damon, DuBois, Steven G., Gorlick, Richard, Mascarenhas, Leo, Harrison, Douglas, Metts, Jonathan, Lessnick, Stephen L., Crompton, Brian D., Loeb, David M., Hernandez, Rose, Larson, Jeff, Stenehjem, David D.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)
Sakane, Naoki, Kwon, Hye-Sook, Pagans, Sara, Kaehlcke, Katrin, Mizusawa, Yasuhiro, Kamada, Masafumi, Lassen, Kara G., Chan, Jonathan, Greene, Warner C., Schnoelzer, Martina, Ott, Melanie
Published in PLoS pathogens (01.08.2011)
Published in PLoS pathogens (01.08.2011)
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Safety, Phamacokinetics (PK), Pharmacodynamics (PD) and Preliminary Activity in Acute Leukemia of Ory-1001, a First-in-Class Inhibitor of Lysine-Specific Histone Demethylase 1A (LSD1/KDM1A): Initial Results from a First-in-Human Phase 1 Study
Somervaille, Tim, Salamero, Olga, Montesinos, Pau, Willekens, Christophe, Perez Simon, Jose Antonio, Pigneux, Arnaud, Recher, Christian, Popat, Rakesh, Molinero, Cesar, Mascaro, Christina, Maes, Tamara, Bosch, Francesc
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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PF277 ALICE: AN AML STUDY WITH LSD1 INHIBITION IN COMBINATION WITH AZACITIDINE IN THE ELDERLY
Montesinos, P., Somervaille, T., Salamero, O., Gutierrez, S., Xaus, J., Buesa, C., Maes, T., Bullock, R.
Published in HemaSphere (01.06.2019)
Published in HemaSphere (01.06.2019)
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DUAL LSD1/HDAC INHIBITORS
GAJENDRAN, Chandru, SIVANANDHAN, Dhanalakshmi, RASTELLI, Luca, SADHU, Naveen, SRIDHARAN, Rajagopal
Year of Publication 22.05.2025
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Year of Publication 22.05.2025
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DUAL LSD1/HDAC INHIBITORS
GAJENDRAN, Chandru, SIVANANDHAN, Dhanalakshmi, RASTELLI, Luca, SADHU, Naveen, SRIDHARAN, Rajagopal
Year of Publication 15.01.2025
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Year of Publication 15.01.2025
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Inhibition of the histone demethylase LSD1 blocks [alpha]-herpesvirus lytic replication and reactivation from latency
Liang, Yu, Vogel, Jodi L, Narayanan, Aarthi, Peng, Hua, Kristie, Thomas M
Published in Nature medicine (01.11.2009)
Published in Nature medicine (01.11.2009)
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DUAL LSD1/HDAC INHIBITORS
GAJENDRAN, Chandru, SIVANANDHAN, Dhanalakshmi, RASTELLI, Luca, SADHU, Naveen, SRIDHARAN, Rajagopal
Year of Publication 15.08.2024
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Year of Publication 15.08.2024
Patent
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DUAL LSD1/HDAC INHIBITORS
GAJENDRAN, Chandru, SIVANANDHAN, Dhanalakshmi, RASTELLI, Luca, SADHU, Naveen, SRIDHARAN, Rajagopal
Year of Publication 14.09.2023
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Year of Publication 14.09.2023
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Emerging Roles of JmjC Domain-Containing Proteins
Accari, Sandra L, Fisher, Paul R
Published in International review of cell and molecular biology (2015)
Published in International review of cell and molecular biology (2015)
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METHODS OF TREATING NF1-MUTANT TUMORS USING LSD1 INHIBITORS
SACILOTTO, Natalia, SOLIVA SOLIVA, Robert, MASCARÓ CRUSAT, Cristina, ROTLLANT POZO, David
Year of Publication 19.03.2025
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Year of Publication 19.03.2025
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