A novel mechanism of neuroprotection: Blood glutamate grabber
Castillo, José, Loza, María Isabel, Mirelman, David, Brea, José, Blanco, Miguel, Sobrino, Tomás, Campos, Francisco
Published in Journal of Cerebral Blood Flow & Metabolism (01.02.2016)
Published in Journal of Cerebral Blood Flow & Metabolism (01.02.2016)
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Book Review
Journal Article
Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HT2BR Ligands
Rataj, Krzysztof, Kelemen, Ádám, Brea, José, Loza, María, Bojarski, Andrzej, Keserű, György
Published in Molecules (Basel, Switzerland) (10.05.2018)
Published in Molecules (Basel, Switzerland) (10.05.2018)
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Journal Article
The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research
Ratnam, Joseline, Zdrazil, Barbara, Digles, Daniela, Cuadrado-Rodriguez, Emiliano, Neefs, Jean-Marc, Tipney, Hannah, Siebes, Ronald, Waagmeester, Andra, Bradley, Glyn, Chau, Chau Han, Richter, Lars, Brea, Jose, Evelo, Chris T, Jacoby, Edgar, Senger, Stefan, Loza, Maria Isabel, Ecker, Gerhard F, Chichester, Christine
Published in PloS one (18.12.2014)
Published in PloS one (18.12.2014)
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Journal Article
Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase
Massari, Serena, Bertagnin, Chiara, Pismataro, Maria Chiara, Donnadio, Anna, Nannetti, Giulio, Felicetti, Tommaso, Di Bona, Stefano, Nizi, Maria Giulia, Tensi, Leonardo, Manfroni, Giuseppe, Loza, Maria Isabel, Sabatini, Stefano, Cecchetti, Violetta, Brea, Jose, Goracci, Laura, Loregian, Arianna, Tabarrini, Oriana
Published in European journal of medicinal chemistry (01.01.2021)
Published in European journal of medicinal chemistry (01.01.2021)
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Journal Article
Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists
Balo, María Carmen, Brea, José, Caamaño, Olga, Fernández, Franco, García-Mera, Xerardo, López, Carmen, Loza, María Isabel, Nieto, María Isabel, Rodríguez-Borges, José Enrique
Published in Bioorganic & medicinal chemistry (15.09.2009)
Published in Bioorganic & medicinal chemistry (15.09.2009)
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Journal Article
Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands
Rodríguez, David, Brea, José, Loza, María Isabel, Carlsson, Jens
Published in Structure (London) (05.08.2014)
Published in Structure (London) (05.08.2014)
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Journal Article
Docking Finds GPCR Ligands in Dark Chemical Matter
Ballante, Flavio, Rudling, Axel, Zeifman, Alexey, Luttens, Andreas, Vo, Duy Duc, Irwin, John J, Kihlberg, Jan, Brea, Jose, Loza, Maria Isabel, Carlsson, Jens
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy
Triana-Martínez, Francisco, Loza, María Isabel, Domínguez, Eduardo
Published in Cells (Basel, Switzerland) (03.02.2020)
Published in Cells (Basel, Switzerland) (03.02.2020)
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Journal Article
Normalization of DNA encoded library affinity selection results driven by high throughput sequencing and HPLC purification
Rama-Garda, Ramón, Amigo, Jorge, Priego, Julián, Molina-Martin, Manuel, Cano, Leticia, Domínguez, Eduardo, Loza, María Isabel, Rivera-Sagredo, Alfonso, de Blas, Jesús
Published in Bioorganic & medicinal chemistry (15.06.2021)
Published in Bioorganic & medicinal chemistry (15.06.2021)
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Journal Article
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Costa-Machado, Luis Filipe, Garcia-Dominguez, Esther, McIntyre, Rebecca L, Lopez-Aceituno, Jose Luis, Ballesteros-Gonzalez, Álvaro, Tapia-Gonzalez, Andrea, Fabregat-Safont, David, Eisenberg, Tobias, Gomez, Jesús, Plaza, Adrian, Sierra-Ramirez, Aranzazu, Perez, Manuel, Villanueva-Bermejo, David, Fornari, Tiziana, Loza, María Isabel, Herradon, Gonzalo, Hofer, Sebastian J, Magnes, Christoph, Madeo, Frank, Duerr, Janet S, Pozo, Oscar J, Galindo, Maximo-Ibo, Del Pino, Isabel, Houtkooper, Riekelt H, Megias, Diego, Viña, Jose, Gomez-Cabrera, Mari Carmen, Fernandez-Marcos, Pablo J
Published in Nature communications (15.05.2023)
Published in Nature communications (15.05.2023)
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Journal Article
A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery
Navarro, Gemma, Sotelo, Eddy, Raïch, Iu, Loza, María Isabel, Brea, Jose, Majellaro, Maria
Published in Molecules (Basel, Switzerland) (01.12.2023)
Published in Molecules (Basel, Switzerland) (01.12.2023)
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Journal Article
Discovery of New Potent Positive Allosteric Modulators of Dopamine D 2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide
Sampaio-Dias, Ivo E, Reis-Mendes, Ana, Costa, Vera Marisa, García-Mera, Xerardo, Brea, José, Loza, María Isabel, Pires-Lima, Beatriz L, Alcoholado, Cristina, Algarra, Manuel, Rodríguez-Borges, José E
Published in Journal of medicinal chemistry (13.05.2021)
Published in Journal of medicinal chemistry (13.05.2021)
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Journal Article
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
Kossatz, Elk, Diez-Alarcia, Rebeca, Gaitonde, Supriya A., Ramon-Duaso, Carla, Stepniewski, Tomasz Maciej, Aranda-Garcia, David, Muneta-Arrate, Itziar, Tepaz, Elodie, Saen-Oon, Suwipa, Soliva, Robert, Shahraki, Aida, Moreira, David, Brea, Jose, Loza, Maria Isabel, de la Torre, Rafael, Kolb, Peter, Bouvier, Michel, Meana, J. Javier, Robledo, Patricia, Selent, Jana
Published in Nature communications (29.05.2024)
Published in Nature communications (29.05.2024)
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Journal Article
Cognitive Deficit in Schizophrenia: From Etiology to Novel Treatments
Martínez, Antón L, Brea, José, Rico, Sara, de Los Frailes, María Teresa, Loza, María Isabel
Published in International journal of molecular sciences (14.09.2021)
Published in International journal of molecular sciences (14.09.2021)
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Journal Article
Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR‑6
Pérez-Areales, F. Javier, Garrido, María, Aso, Ester, Bartolini, Manuela, De Simone, Angela, Espargaró, Alba, Ginex, Tiziana, Sabate, Raimon, Pérez, Belén, Andrisano, Vincenza, Puigoriol-Illamola, Dolors, Pallàs, Mercè, Luque, F. Javier, Loza, María Isabel, Brea, José, Ferrer, Isidro, Ciruela, Francisco, Messeguer, Angel, Muñoz-Torrero, Diego
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Optimization of 2‑Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists
Val, Cristina, Rodríguez-García, Carlos, Prieto-Díaz, Rubén, Crespo, Abel, Azuaje, Jhonny, Carbajales, Carlos, Majellaro, Maria, Díaz-Holguín, Alejandro, Brea, José M, Loza, Maria Isabel, Gioé-Gallo, Claudia, Contino, Marialessandra, Stefanachi, Angela, García-Mera, Xerardo, Estévez, Juan C, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Published in Journal of medicinal chemistry (10.02.2022)
Published in Journal of medicinal chemistry (10.02.2022)
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Journal Article
Natural Tetraponerines: A General Synthesis and Antiproliferative Activity
Bosque, Irene, Gonzalez-Gomez, Jose C, Loza, María Isabel, Brea, José
Published in Journal of organic chemistry (02.05.2014)
Published in Journal of organic chemistry (02.05.2014)
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Journal Article
Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway
Álvarez-Coiradas, Elia, Munteanu, Cristian R., Díaz-Sáez, Laura, Pazos, Alejandro, Huber, Kilian V.M., Loza, María Isabel, Domínguez, Eduardo
Published in International immunopharmacology (01.12.2020)
Published in International immunopharmacology (01.12.2020)
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Journal Article