Specific Inhibition of Hormone-Sensitive Lipase Improves Lipid Profile while Reducing Plasma Glucose
Claus, Thomas H, Lowe, Derek B, Liang, Yin, Salhanick, Arthur I, Lubeski, Christine Keiper, Yang, Ling, Lemoine, Lynn, Zhu, Jian, Clairmont, Kevin B
Published in The Journal of pharmacology and experimental therapeutics (01.12.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2005)
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In vitro SAR of (5-(2 H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase
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Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3‑Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)
Come, Jon H, Collier, Philip N, Henderson, James A, Pierce, Albert C, Davies, Robert J, Le Tiran, Arnaud, O’Dowd, Hardwin, Bandarage, Upul K, Cao, Jingrong, Deininger, David, Grey, Ron, Krueger, Elaine B, Lowe, Derek B, Liang, Jianglin, Liao, Yusheng, Messersmith, David, Nanthakumar, Suganthi, Sizensky, Emmanuelle, Wang, Jian, Xu, Jinwang, Chin, Elaine Y, Damagnez, Veronique, Doran, John D, Dworakowski, Wojciech, Griffith, James P, Jacobs, Marc D, Khare-Pandit, Suvarna, Mahajan, Sudipta, Moody, Cameron S, Aronov, Alex M
Published in Journal of medicinal chemistry (28.06.2018)
Published in Journal of medicinal chemistry (28.06.2018)
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Quinazolinone Derivatives as Orally Available Ghrelin Receptor Antagonists for the Treatment of Diabetes and Obesity
Rudolph, Joachim, Esler, William P, O'Connor, Stephen, Coish, Philip D. G, Wickens, Philip L, Brands, Michael, Bierer, Donald E, Bloomquist, Brian T, Bondar, Georgiy, Chen, Libing, Chuang, Chih-Yuan, Claus, Thomas H, Fathi, Zahra, Fu, Wenlang, Khire, Uday R, Kristie, James A, Liu, Xiao-Gao, Lowe, Derek B, McClure, Andrea C, Michels, Martin, Ortiz, Astrid A, Ramsden, Philip D, Schoenleber, Robert W, Shelekhin, Tatiana E, Vakalopoulos, Alexandros, Tang, Weifeng, Wang, Lei, Yi, Lin, Gardell, Stephen J, Livingston, James N, Sweet, Laurel J, Bullock, William H
Published in Journal of medicinal chemistry (18.10.2007)
Published in Journal of medicinal chemistry (18.10.2007)
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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill, Bagi, Cedo M., Akuche, Christiana, Bacchiocchi, Antonietta, Baryza, Jeremy, Blue, Marie-Luise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James H., Conrad, Patricia, Dixon, Brian R., Ehrlich, Paul P., Gane, Todd, Gunn, David, Joe, Ted, Johnson, Jeffrey S., Jordan, Jerold, Kramss, Richard, Liu, Peiying, Levy, Joan, Lowe, Derek B., McAlexander, Ian, Natero, Reina, Redman, Anikó M., Scott, William J., Town, Christopher, Wang, Ming, Wang, Yamin, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals
CAREY, Galen J, BILLARD, William, TEDESCO, Richard P, WATKINS, Robert W, COFFIN, Vicki L, BINCH, Herbert III, COHEN-WILLIAMS, Mary, CROSBY, Gordon, GRZELAK, Michael, GUZIK, Henry, KOZLOWSKI, Joseph A, LOWE, Derek B, POND, Annamarie J
Published in European journal of pharmacology (16.11.2001)
Published in European journal of pharmacology (16.11.2001)
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Substituted indanylacetic acids as PPAR-α–γ activators
Lowe, Derek B., Bifulco, Neil, Bullock, William H., Claus, Thomas, Coish, Philip, Dai, Miao, Dela Cruz, Fernando E., Dickson, David, Fan, Dongping, Hoover-Litty, Helana, Li, Tindy, Ma, Xin, Mannelly, Gretchen, Monahan, Mary-Katherine, Muegge, Ingo, O’Connor, Stephen, Rodriguez, Mareli, Shelekhin, Tatiana, Stolle, Andreas, Sweet, Laurel, Wang, Ming, Wang, Yamin, Zhang, Chengzhi, Zhang, Hai-Jun, Zhang, Mingbao, Zhao, Kake, Zhao, Qian, Zhu, Jian, Zhu, Lei, Tsutsumi, Manami
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
KOZLOWSKI, Joseph A, LOWE, Derek B, BINCH, Herbert III, LACHOWICZ, Jean E, GUZIK, Henry S, GUOWEI ZHOU, RUPERTO, Vilma B, DUFFY, Ruth A, MCQUADE, Robert, CROSBY, Gordon JR, TAYLOR, Lisa A, BILLARD, William
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Journal Article
SCH 57790, a selective muscarinic M 2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals
Carey, Galen J., Billard, William, Binch, Herbert, Cohen-Williams, Mary, Crosby, Gordon, Grzelak, Michael, Guzik, Henry, Kozlowski, Joseph A., Lowe, Derek B., Pond, Annamarie J., Tedesco, Richard P., Watkins, Robert W., Coffin, Vicki L.
Published in European journal of pharmacology (16.11.2001)
Published in European journal of pharmacology (16.11.2001)
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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate
Wood, Jill, Bagi, Cedo M, Akuche, Christiana, Bacchiocchi, Antonietta, Baryza, Jeremy, Blue, Marie-Luise, Brennan, Catherine, Campbell, Ann-Marie, Choi, Soongyu, Cook, James H, Conrad, Patricia, Dixon, Brian R, Ehrlich, Paul P, Gane, Todd, Gunn, David, Joe, Ted, Johnson, Jeffrey S, Jordan, Jerold, Kramss, Richard, Liu, Peiying, Levy, Joan, Lowe, Derek B, McAlexander, Ian, Natero, Reina, Redman, Anikó M, Scott, William J, Town, Christopher, Wang, Ming, Wang, Yamin, Zhang, Zhonghua
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Diphenyl sulfoxides as selective antagonists of the muscarinic M 2 receptor
Kozlowski, Joseph A, Lowe, Derek B, Guzik, Henry S, Zhou, Guowei, Ruperto, Vilma B, Duffy, Ruth A, McQuade, Robert, Crosby, Gordon, Taylor, Lisa A, Billard, William, Binch, Herbert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
ZHANG CHENGZHI, COISH PHILIP D. G, LOWE DEREK B, BULLOCK WILLIAM H, WANG YAMIN, LIVINGSTON JAMES N, MA XIN, ZHU LEI, ZHANG MINGBAO, STOLLE ANDREAS, WICKENS PHILIP L, ZHANG HAI-JUN, MUGGE INGO A, TSUTSUMI MANAMI, WANG MING
Year of Publication 08.10.2013
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Year of Publication 08.10.2013
Patent
Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
ZHANG CHENGZHI, COISH PHILIP D. G, LOWE DEREK B, BULLOCK WILLIAM H, WANG YAMIN, LIVINGSTON JAMES N, MA XIN, ZHU LEI, ZHANG MINGBAO, STOLLE ANDREAS, WICKENS PHILIP L, ZHANG HAI-JUN, MUGGE INGO A, TSUTSUMI MANAMI, WANG MING
Year of Publication 24.09.2013
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Year of Publication 24.09.2013
Patent