An in vivo platform to select and evolve aggregation-resistant proteins
Ebo, Jessica S., Saunders, Janet C., Devine, Paul W. A., Gordon, Alice M., Warwick, Amy S., Schiffrin, Bob, Chin, Stacey E., England, Elizabeth, Button, James D., Lloyd, Christopher, Bond, Nicholas J., Ashcroft, Alison E., Radford, Sheena E., Lowe, David C., Brockwell, David J.
Published in Nature communications (14.04.2020)
Published in Nature communications (14.04.2020)
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Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS
Devine, Paul W. A., Fisher, Henry C., Calabrese, Antonio N., Whelan, Fiona, Higazi, Daniel R., Potts, Jennifer R., Lowe, David C., Radford, Sheena E., Ashcroft, Alison E.
Published in Journal of the American Society for Mass Spectrometry (01.09.2017)
Published in Journal of the American Society for Mass Spectrometry (01.09.2017)
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Short-term variations in the oxidizing power of the atmosphere
Manning, Martin R, Lowe, David C, Moss, Rowena C, Bodeker, Gregory E, Allan, William
Published in Nature (18.08.2005)
Published in Nature (18.08.2005)
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Inducing protein aggregation by extensional flow
Dobson, John, Kumar, Amit, Willis, Leon F., Tuma, Roman, Higazi, Daniel R., Turner, Richard, Lowe, David C., Ashcroft, Alison E., Radford, Sheena E., Kapur, Nikil, Brockwell, David J.
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2017)
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Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
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Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity
Rudnicka, Dominika, Oszmiana, Anna, Finch, Donna K., Strickland, Ian, Schofield, Darren J., Lowe, David C., Sleeman, Matthew A., Davis, Daniel M.
Published in Blood (06.06.2013)
Published in Blood (06.06.2013)
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Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Published in Scientific reports (20.12.2016)
Published in Scientific reports (20.12.2016)
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Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability
Edgeworth, Matthew J., Phillips, Jonathan J., Lowe, David C., Kippen, Alistair D., Higazi, Daniel R., Scrivens, James H.
Published in Angewandte Chemie International Edition (07.12.2015)
Published in Angewandte Chemie International Edition (07.12.2015)
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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Vousden, Katherine A., Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M., Newton, Philip, Johnson, Daniel J. D., Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R., Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A., Sleeman, Matthew A., Lowe, David C., Huntington, James A., Vaughan, Tristan J.
Published in Scientific reports (07.02.2019)
Published in Scientific reports (07.02.2019)
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Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics
Finch, Donna K., Sleeman, Matthew A., Moisan, Jacques, Ferraro, Franco, Botterell, Sara, Campbell, Jamie, Cochrane, Duncan, Cruwys, Simon, England, Elizabeth, Lane, Steven, Rendall, Elizabeth, Sinha, Monisha, Walker, Craig, Rees, Gareth, Bowen, Michael A., Schneider, Amy, Liang, Meina, Faggioni, Raffaella, Fung, Michael, Mallinder, Philip R., Wilkinson, Trevor, Kolbeck, Roland, Vaughan, Tristan, Lowe, David C.
Published in Journal of molecular biology (26.08.2011)
Published in Journal of molecular biology (26.08.2011)
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Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1
Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
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The INNs and outs of antibody nonproprietary names
Jones, Tim D., Carter, Paul J., Plückthun, Andreas, Vásquez, Max, Holgate, Robert G.E., Hötzel, Isidro, Popplewell, Andrew G., Parren, Paul W.H.I., Enzelberger, Markus, Rademaker, Hendrik J., Clark, Michael R., Lowe, David C., Dahiyat, Bassil I., Smith, Victoria, Lambert, John M., Wu, Herren, Reilly, Mary, Haurum, John S., Dübel, Stefan, Huston, James S., Schirrmann, Thomas, Janssen, Richard A.J., Steegmaier, Martin, Gross, Jane A., Bradbury, Andrew R.M., Burton, Dennis R., Dimitrov, Dimiter S., Chester, Kerry A., Glennie, Martin J., Davies, Julian, Walker, Adam, Martin, Steve, McCafferty, John, Baker, Matthew P.
Published in mAbs (02.01.2016)
Published in mAbs (02.01.2016)
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Journal Article
Affinity maturation of a novel antagonistic human monoclonal antibody with a long V H CDR3 targeting the Class A GPCR formyl-peptide receptor 1
Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (02.01.2015)
Published in mAbs (02.01.2015)
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A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors
Webster, Carl I, Bryson, Christine J, Cloake, Edward A, Jones, Tim D, Austin, Mark J, Karle, Anette C, Spindeldreher, Sebastian, Lowe, David C, Baker, Matthew P
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Engineering a High-Affinity Anti-IL-15 Antibody: Crystal Structure Reveals an α-Helix in VH CDR3 as Key Component of Paratope
Lowe, David C., Gerhardt, Stefan, Ward, Alison, Hargreaves, David, Anderson, Malcolm, Ferraro, Franco, Pauptit, Richard A., Pattison, Debbie V., Buchanan, Catriona, Popovic, Bojana, Finch, Donna K., Wilkinson, Trevor, Sleeman, Matthew, Vaughan, Tristan J., Mallinder, Philip R.
Published in Journal of molecular biology (11.02.2011)
Published in Journal of molecular biology (11.02.2011)
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Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity
Groves, Maria AT, Amanuel, Lily, Campbell, Jamie I, Rees, D Gareth, Sridharan, Sudharsan, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Published in mAbs (01.01.2014)
Published in mAbs (01.01.2014)
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