Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation
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Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L. Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J. Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A, Allen, Jennifer R, Allen, John G, Amegadzie, Albert K, Ashton, Kate S, Booker, Shon K, Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J, Goodman, Guy, Kopecky, David J, Liu, Longbin, Lopez, Patricia, Low, Jonathan D, Ma, Vu, Minatti, Ana E, Nguyen, Thomas T, Nishimura, Nobuko, Pickrell, Alexander J, Reed, Anthony B, Shin, Youngsook, Siegmund, Aaron C, Tamayo, Nuria A, Tegley, Christopher M, Walton, Mary C, Wang, Hui-Ling, Wurz, Ryan P, Xue, May, Yang, Kevin C, Achanta, Pragathi, Bartberger, Michael D, Canon, Jude, Hollis, L Steven, McCarter, John D, Mohr, Christopher, Rex, Karen, Saiki, Anne Y, San Miguel, Tisha, Volak, Laurie P, Wang, Kevin H, Whittington, Douglas A, Zech, Stephan G, Lipford, J Russell, Cee, Victor J
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Journal Article
Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D
Low, Jonathan D., Bartberger, Michael D., Chen, Kui, Cheng, Yuan, Fielden, Mark R., Gore, Vijay, Hickman, Dean, Liu, Qingyian, Sickmier, E. Allen, Vargas, Hugo M., Werner, Jonathan, White, Ryan D., Whittington, Douglas A., Wood, Stephen, Minatti, Ana E.
Published in MedChemComm (01.06.2017)
Published in MedChemComm (01.06.2017)
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Journal Article
Discovery of a Covalent Inhibitor of KRAS(G12C) (AMG 510) for the Treatment of Solid Tumors
Lanman, Brian A., Allen, Jennifer R., Allen, John G., Amegadzie, Albert K., Ashton, Kate S., Booker, Shon K., Chen, Jian Jeffrey, Chen, Ning, Frohn, Michael J., Goodman, Guy, Kopecky, David J., Liu, Longbin, Lopez, Patricia, Low, Jonathan D., Ma, Vu, Minatti, Ana E., Nguyen, Thomas T., Nishimura, Nobuko, Pickrell, Alexander J., Reed, Anthony B., Shin, Youngsook, Siegmund, Aaron C., Tamayo, Nuria A., Tegley, Christopher M., Walton, Mary C., Wang, Hui-Ling, Wurz, Ryan P., Xue, May, Yang, Kevin C., Achanta, Pragathi, Bartberger, Michael D., Canon, Jude, Hollis, L. Steven, McCarter, John D., Mohr, Christopher, Rex, Karen, Saiki, Anne Y., San Miguel, Tisha, Volak, Laurie P., Wang, Kevin H., Whittington, Douglas A., Zech, Stephan G., Lipford, J. Russell, Cee, Victor J.
Published in Journal of medicinal chemistry (09.01.2020)
Published in Journal of medicinal chemistry (09.01.2020)
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Year of Publication 26.12.2019
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Year of Publication 26.12.2019
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PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE
NISHIMURA NOBUKO, LOW JONATHAN D, AMEGADZIE ALBERT, HARRINGTON PAUL E, MA VU VAN, WHITE RYAN, ALLEN JENNIFER R, SMITH ADRIAN L, SHAM KELVIN, XUE QIUFEN, QIAN WENYUAN, RUMFELT SHANNON, FROHN MICHAEL J, GUZMAN PEREZ ANGEL, BROWN JAMES, RZASA ROBERT M, MINATTI ANA ELENA, LOPEZ PATRICIA
Year of Publication 06.11.2015
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Year of Publication 06.11.2015
Patent
Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin DThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00106a
Low, Jonathan D, Bartberger, Michael D, Chen, Kui, Cheng, Yuan, Fielden, Mark R, Gore, Vijay, Hickman, Dean, Liu, Qingyian, Allen Sickmier, E, Vargas, Hugo M, Werner, Jonathan, White, Ryan D, Whittington, Douglas A, Wood, Stephen, Minatti, Ana E
Year of Publication 21.06.2017
Year of Publication 21.06.2017
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Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c7md00106a
Low, Jonathan D., Bartberger, Michael D., Chen, Kui, Cheng, Yuan, Fielden, Mark R., Gore, Vijay, Hickman, Dean, Liu, Qingyian, Allen Sickmier, E., Vargas, Hugo M., Werner, Jonathan, White, Ryan D., Whittington, Douglas A., Wood, Stephen, Minatti, Ana E.
Published in MedChemComm (27.04.2017)
Published in MedChemComm (27.04.2017)
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INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME
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Year of Publication 29.08.2024
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KRAS G12C inhibitors for the treatment of cancer
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Year of Publication 28.05.2024
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Year of Publication 19.12.2023
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Year of Publication 27.11.2023
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Year of Publication 24.11.2023
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