Search Results - "LOVEY; RAYMOND" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

by Venkatraman, Srikanth, Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond, Hendrata, Siska, Huang, Yuhua, Pan, Weidong, Parekh, Tejal, Pinto, Patrick, Popov, Veljko, Pike, Russel, Ruan, Sumei, Santhanam, Bama, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Kong, Jianshe, Liang, Xiang, Wong, Jesse, Liu, Rong, Butkiewicz, Nancy, Chase, Robert, Hart, Andrea, Agrawal, Sony, Ingravallo, Paul, Pichardo, John, Kong, Rong, Baroudy, Bahige, Malcolm, Bruce, Guo, Zhuyan, Prongay, Andrew, Madison, Vincent, Broske, Lisa, Cui, Xiaoming, Cheng, Kuo-Chi, Hsieh, Yunsheng, Brisson, Jean-Marc, Prelusky, Danial, Korfmacher, Walter, White, Ronald, Bogdanowich-Knipp, Susan, Pavlovsky, Anastasia, Bradley, Prudence, Saksena, Anil K, Ganguly, Ashit, Piwinski, John, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (05.10.2006)

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Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles

Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles

by Velázquez, Francisco, Sannigrahi, Mousumi, Bennett, Frank, Lovey, Raymond G, Arasappan, Ashok, Bogen, Stéphane, Nair, Latha, Venkatraman, Srikanth, Blackman, Melissa, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina, Pinto, Patrick, Cheng, Kuo-Chi, Tong, Xiao, McPhail, Andrew T, Njoroge, F. George
Published in Journal of medicinal chemistry (22.04.2010)

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Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

by Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent
Published in Journal of medicinal chemistry (17.05.2007)

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Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

by Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Venkatraman, Srikanth, Pan, Weidong, Parekh, Tajel, Pike, Russel E, Ruan, Sumei, Liu, Rong, Baroudy, Bahige, Agrawal, Sony, Chase, Robert, Ingravallo, Paul, Pichardo, John, Prongay, Andrew, Brisson, Jean-Marc, Hsieh, Tony Y, Cheng, Kuo-Chi, Kemp, Scott J, Levy, Odile E, Lim-Wilby, Marguerita, Tamura, Susan Y, Saksena, Anil K, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (04.05.2006)

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Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

by Bennett, Frank, Saksena, Anil K., Lovey, Raymond G., Liu, Yi-Tsung, Patel, Naginbhai M., Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M., Ganguly, Ashit K., Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S., Nomeir, Amin
Published in Bioorganic & medicinal chemistry letters (2006)

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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

by Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of synchrotron radiation (01.05.2008)

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Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048

Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048

by Lovey, Raymond G, Saksena, Anil K, Girijavallabhan, Viyyoor M, Blundell, Paul, Guzik, Henry, Loebenberg, David, Parmegiani, Raulo M, Cacciapuoti, Anthony
Published in Bioorganic & medicinal chemistry letters (08.07.2002)

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Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR

by Saksena, Anil K., Girijavallabhan, Viyyoor M., Wang, Haiyan, Lovey, Raymond G., Guenter, Frank, Mergelsberg, Ingrid, Puar, Mohinder S.
Published in Tetrahedron letters (01.10.2004)

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Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

by Kaminski, James J, Bristol, James A, Puchalski, Chester, Lovey, Raymond G, Elliott, Arthur J, Guzik, Henry, Solomon, Daniel M, Conn, David J, Domalski, Martin S
Published in Journal of medicinal chemistry (01.07.1985)

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Antiulcer agents. 4. Conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogs

Antiulcer agents. 4. Conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogs

by Kaminski, James J, Puchalski, Chester, Solomon, Daniel M, Rizvi, Razia K, Conn, David J, Elliott, Arthur J, Lovey, Raymond G, Guzik, Henry, Chiu, P. J. S
Published in Journal of medicinal chemistry (01.08.1989)

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A convenient synthesis of polyoxamic acid, 5-O-carbamoylpolyoxamic acid, and their unnatural D isomers

A convenient synthesis of polyoxamic acid, 5-O-carbamoylpolyoxamic acid, and their unnatural D isomers

by Saksena, Anil K, Lovey, Raymond G, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, McPhail, Andrew T
Published in Journal of organic chemistry (01.12.1986)

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A Facile and Efficient Synthesis of 3,3-Dimethyl Isopropylidene Proline From (+)-3-Carene

A Facile and Efficient Synthesis of 3,3-Dimethyl Isopropylidene Proline From (+)-3-Carene

by Nair, Latha G, Saksena, Anil, Lovey, Raymond, Sannigrahi, Mousumi, Wong, Jesse, Kong, Jianshe, Fu, Xiaoyong, Girijavallabhan, Viyyoor
Published in Journal of organic chemistry (19.02.2010)

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Isobenzofurans as conformationally constrained miconazole analogs with improved antifungal potency

Isobenzofurans as conformationally constrained miconazole analogs with improved antifungal potency

by Lovey, Raymond G, Elliott, Arthur J, Kaminski, James J, Loebenberg, David, Parmegiani, Raulo M, Rane, D. F, Girijavallabhan, Viyyoor M, Pike, Russel E, Guzik, Henry
Published in Journal of medicinal chemistry (01.10.1992)

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The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor

The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir®: A change in direction in the search for a second generation HCV NS3 protease inhibitor

by Bennett, Frank, Huang, Yuhua, Hendrata, Siska, Lovey, Raymond, Bogen, Stephane L., Pan, Weidong, Guo, Zhuyan, Prongay, Andrew, Chen, Kevin X., Arasappan, Ashok, Venkatraman, Srikanth, Velazquez, Francisco, Nair, Latha, Sannigrahi, Mousumi, Tong, Xiao, Pichardo, John, Cheng, Kuo-Chi, Girijavallabhan, Viyyoor M., Saksena, Anil K., Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (15.04.2010)

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Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

by Saksena, Anil K, Girijavallabhan, Viyyoor M, Lovey, Raymond G, Desai, Jagdish A, Pike, Russell E, Jao, Edwin, Wang, Haiyan, Ganguly, Ashit K, Loebenberg, David, Hare, Roberta S, Cacciapuoti, Anthony, Parmegiani, Raulo M
Published in Bioorganic & medicinal chemistry letters (19.01.1995)

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Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs

Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs

by Kaminski, James J, Hilbert, James M, Pramanik, B. N, Solomon, Daniel M, Conn, David J, Rizvi, Razia K, Elliott, Arthur J, Guzik, Henry, Lovey, Raymond G
Published in Journal of medicinal chemistry (01.11.1987)

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Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

by Nomeir, Amin A, Pramanik, Birendra N, Heimark, Larry, Bennett, Frank, Veals, John, Bartner, Peter, Hilbert, Maryjane, Saksena, Anil, McNamara, Paul, Girijavallabhan, Viyyoor, Ganguly, Ashit K, Lovey, Raymond, Pike, Russell, Wang, Haiyan, Liu, Yi-Tsung, Kumari, Pramila, Korfmacher, Walter, Lin, Chin-Chung, Cacciapuoti, Anthony, Loebenberg, David, Hare, Roberta, Miller, George, Pickett, Cecil
Published in Journal of mass spectrometry. (01.04.2008)

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Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines

Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines

by Bristol, James A, Gold, Elijah H, Gross, Irwin, Lovey, Raymond G, Long, James F
Published in Journal of medicinal chemistry (01.08.1981)

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Synthesis of 3,4-dihydro-4-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-ones by a novel rearrangement of a 5H-[1]benzopyrano[2,3-b]pyridine derivative

Synthesis of 3,4-dihydro-4-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-ones by a novel rearrangement of a 5H-[1]benzopyrano[2,3-b]pyridine derivative

by Bristol, James A, Lovey, Raymond G
Published in Journal of organic chemistry (01.05.1980)

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Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate

Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate

by Tamarez, Maria, Morgan, Brian, Wong, George S. K, Tong, Weidong, Bennett, Frank, Lovey, Raymond, McCormick, Jinping L, Zaks, Aleksey
Published in Organic process research & development (01.11.2003)

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