Search Results - "LOVEY, RAYMOND, G" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

by Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent
Published in Journal of medicinal chemistry (17.05.2007)

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Journal Article

Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles

Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles

by Velázquez, Francisco, Sannigrahi, Mousumi, Bennett, Frank, Lovey, Raymond G, Arasappan, Ashok, Bogen, Stéphane, Nair, Latha, Venkatraman, Srikanth, Blackman, Melissa, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina, Pinto, Patrick, Cheng, Kuo-Chi, Tong, Xiao, McPhail, Andrew T, Njoroge, F. George
Published in Journal of medicinal chemistry (22.04.2010)

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Journal Article

Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication

by Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Venkatraman, Srikanth, Pan, Weidong, Parekh, Tajel, Pike, Russel E, Ruan, Sumei, Liu, Rong, Baroudy, Bahige, Agrawal, Sony, Chase, Robert, Ingravallo, Paul, Pichardo, John, Prongay, Andrew, Brisson, Jean-Marc, Hsieh, Tony Y, Cheng, Kuo-Chi, Kemp, Scott J, Levy, Odile E, Lim-Wilby, Marguerita, Tamura, Susan Y, Saksena, Anil K, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (04.05.2006)

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Journal Article

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 ( 1), and the discovery of posaconazole [Sch 56592; 2 or ( S, S)- 5]

by Bennett, Frank, Saksena, Anil K., Lovey, Raymond G., Liu, Yi-Tsung, Patel, Naginbhai M., Pinto, Patrick, Pike, Russel, Jao, Edwin, Girijavallabhan, Viyyoor M., Ganguly, Ashit K., Loebenberg, David, Wang, Haiyan, Cacciapuoti, Anthony, Moss, Eugene, Menzel, Fred, Hare, Roberta S., Nomeir, Amin
Published in Bioorganic & medicinal chemistry letters (2006)

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Journal Article

Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines

by Kaminski, James J, Bristol, James A, Puchalski, Chester, Lovey, Raymond G, Elliott, Arthur J, Guzik, Henry, Solomon, Daniel M, Conn, David J, Domalski, Martin S
Published in Journal of medicinal chemistry (01.07.1985)

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Journal Article

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

by Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of synchrotron radiation (01.05.2008)

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Journal Article

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR

by Saksena, Anil K., Girijavallabhan, Viyyoor M., Wang, Haiyan, Lovey, Raymond G., Guenter, Frank, Mergelsberg, Ingrid, Puar, Mohinder S.
Published in Tetrahedron letters (01.10.2004)

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Journal Article

Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048

Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048

by Lovey, Raymond G, Saksena, Anil K, Girijavallabhan, Viyyoor M, Blundell, Paul, Guzik, Henry, Loebenberg, David, Parmegiani, Raulo M, Cacciapuoti, Anthony
Published in Bioorganic & medicinal chemistry letters (08.07.2002)

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Journal Article

SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE

by ARASAPPAN ASHOK, GIRIJAVALLABHAN VIYYOOR M, VENKATRAMAN SRIKANTH, HUANG YUHUA, LOVEY RAYMOND G, SANNIGRAHI MOUSUMI, HENDRATA SISKA, BOGEN STEPHANE L, NAIR LATHA, CHEN KEVIN X, NJOROGE F. GEORGE, SAKSENA ANIL K, VELAZQUEZ FRANCISCO, BENNETT FRANK, LIU YI TSUNG
Year of Publication 21.02.2013

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Patent

Antiulcer agents. 4. Conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogs

Antiulcer agents. 4. Conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogs

by Kaminski, James J, Puchalski, Chester, Solomon, Daniel M, Rizvi, Razia K, Conn, David J, Elliott, Arthur J, Lovey, Raymond G, Guzik, Henry, Chiu, P. J. S
Published in Journal of medicinal chemistry (01.08.1989)

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Journal Article

A convenient synthesis of polyoxamic acid, 5-O-carbamoylpolyoxamic acid, and their unnatural D isomers

A convenient synthesis of polyoxamic acid, 5-O-carbamoylpolyoxamic acid, and their unnatural D isomers

by Saksena, Anil K, Lovey, Raymond G, Girijavallabhan, Viyyoor M, Ganguly, Ashit K, McPhail, Andrew T
Published in Journal of organic chemistry (01.12.1986)

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Journal Article

Isobenzofurans as conformationally constrained miconazole analogs with improved antifungal potency

Isobenzofurans as conformationally constrained miconazole analogs with improved antifungal potency

by Lovey, Raymond G, Elliott, Arthur J, Kaminski, James J, Loebenberg, David, Parmegiani, Raulo M, Rane, D. F, Girijavallabhan, Viyyoor M, Pike, Russel E, Guzik, Henry
Published in Journal of medicinal chemistry (01.10.1992)

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Journal Article

Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

by Saksena, Anil K, Girijavallabhan, Viyyoor M, Lovey, Raymond G, Desai, Jagdish A, Pike, Russell E, Jao, Edwin, Wang, Haiyan, Ganguly, Ashit K, Loebenberg, David, Hare, Roberta S, Cacciapuoti, Anthony, Parmegiani, Raulo M
Published in Bioorganic & medicinal chemistry letters (19.01.1995)

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Journal Article

Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs

Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogs

by Kaminski, James J, Hilbert, James M, Pramanik, B. N, Solomon, Daniel M, Conn, David J, Rizvi, Razia K, Elliott, Arthur J, Guzik, Henry, Lovey, Raymond G
Published in Journal of medicinal chemistry (01.11.1987)

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Journal Article

Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines

Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines

by Bristol, James A, Gold, Elijah H, Gross, Irwin, Lovey, Raymond G, Long, James F
Published in Journal of medicinal chemistry (01.08.1981)

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Journal Article

Synthesis of 3,4-dihydro-4-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-ones by a novel rearrangement of a 5H-[1]benzopyrano[2,3-b]pyridine derivative

Synthesis of 3,4-dihydro-4-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-ones by a novel rearrangement of a 5H-[1]benzopyrano[2,3-b]pyridine derivative

by Bristol, James A, Lovey, Raymond G
Published in Journal of organic chemistry (01.05.1980)

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Journal Article

Gastric antisecretory agents. 1. Antisecretory and antiulcer activity of 5H-[1]benzopyrano[2,3-b]pyridin-5-ylureas and 5H-[1]benzothiopyrano[2,3-b]pyridin-5-ylureas

Gastric antisecretory agents. 1. Antisecretory and antiulcer activity of 5H-[1]benzopyrano[2,3-b]pyridin-5-ylureas and 5H-[1]benzothiopyrano[2,3-b]pyridin-5-ylureas

by Bristol, James A, Gold, Elijah H, Lovey, Raymond G, Long, James F
Published in Journal of medicinal chemistry (01.08.1981)

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Journal Article

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of Noxafil(R) side chain and a synthesis of Noxafil(R)

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of Noxafil(R) side chain and a synthesis of Noxafil(R)

by Saksena, AK, Girijavallabhan, VM, Wang, HY, Lovey, RG, Guenter, F, Mergelsberg, Puar, MS
Published in Tetrahedron letters (25.10.2004)

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Journal Article

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of Noxafil R side chain and a synthesis of Noxafil R

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of Noxafil R side chain and a synthesis of Noxafil R

by Saksena, Anil K., Girijavallabhan, Viyyoor M., Wang, Haiyan, Lovey, Raymond G., Guenter, Frank, Mergelsberg, Ingrid, Puar, Mohinder S.
Published in Tetrahedron letters (2004)

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Journal Article

PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012

PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012

by Lovey, Raymond G., Saksena, Anil K., Girijavallabhan, Viyyoor M.
Published in Tetrahedron letters (15.08.1994)

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Journal Article

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