Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin‑1
Casimiro-Garcia, Agustin, Allais, Christophe, Brennan, Agnes, Choi, Chulho, Dower, Gabriela, Farley, Kathleen A, Fleming, Margaret, Flick, Andrew, Frisbie, Richard K, Hall, Justin, Hepworth, David, Jones, Hannah, Knafels, John D, Kortum, Steve, Lovering, Frank E, Mathias, John P, Mohan, Sashi, Morgan, Paul M, Parng, Chuenlei, Parris, Kevin, Pullen, Nick, Schlerman, Franklin, Stansfield, John, Strohbach, Joseph W, Vajdos, Felix F, Vincent, Fabien, Wang, Hong, Wang, Xiaolun, Webster, Robert, Wright, Stephen W
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
Get full text
Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α2α
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H, Khor, SooPeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Acylguanidines as Small-Molecule β-Secretase Inhibitors
Cole, Derek C, Manas, Eric S, Stock, Joseph R, Condon, Jeffrey S, Jennings, Lee D, Aulabaugh, Ann, Chopra, Rajiv, Cowling, Rebecca, Ellingboe, John W, Fan, Kristi Y, Harrison, Boyd L, Hu, Yun, Jacobsen, Steve, Jin, Guixan, Lin, Laura, Lovering, Frank E, Malamas, Michael S, Stahl, Mark L, Strand, James, Sukhdeo, Mohani N, Svenson, Kristine, Turner, M. James, Wagner, Erik, Wu, Junjun, Zhou, Ping, Bard, Jonathan
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
Get full text
Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A2α
LEE, Katherine L, FOLEY, Megan A, KHOR, Soopeang, XIN XU, GOODWIN, Debra G, RAMARAO, Manjunath K, NICKERSON-NUTTER, Cheryl, DONAHUE, Frances, SHERRY KU, M, DARK, James D, MCKEW, John C, CHEN, Lihren, BEHNKE, Mark L, LOVERING, Frank E, KIRINCICH, Steven J, WEIHENG WANG, SHIM, Jaechul, TAM, Steve, SHEN, Marina W. H
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Identification of potent and selective TACE inhibitors via the S1 pocket
Condon, Jeffrey S., Joseph-McCarthy, Diane, Levin, Jeremy I., Lombart, Henry-Georges, Lovering, Frank E., Sun, Linhong, Wang, Weiheng, Xu, Weixin, Zhang, Yuhua
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
Get full text
Journal Article
Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization
McKew, John C, Foley, Megan A, Thakker, Paresh, Behnke, Mark L, Lovering, Frank E, Sum, Fuk-Wah, Tam, Steve, Wu, Kun, Shen, Marina W. H, Zhang, Wen, Gonzalez, Mario, Liu, Shanghao, Mahadevan, Anu, Sard, Howard, Khor, Soo Peang, Clark, James D
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
Get full text
Journal Article
Identification of potent and selective MMP-13 inhibitors
Wu, Junjun, Rush, Thomas S., Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
Get full text
Journal Article
Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Lee, Katherine L, Ambler, Catherine M, Anderson, David R, Boscoe, Brian P, Bree, Andrea G, Brodfuehrer, Joanne I, Chang, Jeanne S, Choi, Chulho, Chung, Seungwon, Curran, Kevin J, Day, Jacqueline E, Dehnhardt, Christoph M, Dower, Ken, Drozda, Susan E, Frisbie, Richard K, Gavrin, Lori K, Goldberg, Joel A, Han, Seungil, Hegen, Martin, Hepworth, David, Hope, Heidi R, Kamtekar, Satwik, Kilty, Iain C, Lee, Arthur, Lin, Lih-Ling, Lovering, Frank E, Lowe, Michael D, Mathias, John P, Morgan, Heidi M, Murphy, Elizabeth A, Papaioannou, Nikolaos, Patny, Akshay, Pierce, Betsy S, Rao, Vikram R, Saiah, Eddine, Samardjiev, Ivan J, Samas, Brian M, Shen, Marina W. H, Shin, Julia H, Soutter, Holly H, Strohbach, Joseph W, Symanowicz, Peter T, Thomason, Jennifer R, Trzupek, John D, Vargas, Richard, Vincent, Fabien, Yan, Jiangli, Zapf, Christoph W, Wright, Stephen W
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
Discovery of ecopladib, an indole inhibitor of cytosolic phospholipase A(2)alpha
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (22.03.2007)
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Journal Article
Conformationally restricted inhibitors of the high affinity [formula omitted]-glutamate transporter
Bridges, Richard J., Lovering, Frank E., Humphrey, John M., Stanley, Mark S., Blakely, Tracy N., Cristofaro, Michael F., Chamberlin, A.Richard
Published in Bioorganic & medicinal chemistry letters (1993)
Published in Bioorganic & medicinal chemistry letters (1993)
Get full text
Journal Article
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha
Lee, Katherine L, Foley, Megan A, Chen, Lihren, Behnke, Mark L, Lovering, Frank E, Kirincich, Steven J, Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W H, Khor, Soopeang, Xu, Xin, Goodwin, Debra G, Ramarao, Manjunath K, Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M Sherry, Clark, James D, McKew, John C
Published in Journal of medicinal chemistry (22.03.2007)
Get full text
Published in Journal of medicinal chemistry (22.03.2007)
Journal Article
Discovery of Ecopladib, an Indole Inhibitor of Cytosolic Phospholipase Α 2 α
Lee, Katherine L., Foley, Megan A., Chen, Lihren, Behnke, Mark L., Lovering, Frank E., Kirincich, Steven J., Wang, Weiheng, Shim, Jaechul, Tam, Steve, Shen, Marina W. H., Khor, SooPeang, Xu, Xin, Goodwin, Debra G., Ramarao, Manjunath K., Nickerson-Nutter, Cheryl, Donahue, Frances, Ku, M. Sherry, Clark, James D., McKew, John C.
Published in Journal of medicinal chemistry (01.03.2007)
Published in Journal of medicinal chemistry (01.03.2007)
Get full text
Journal Article
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization
McKew, John C, Foley, Megan A, Thakker, Paresh, Behnke, Mark L, Lovering, Frank E, Sum, Fuk-Wah, Tam, Steve, Wu, Kun, Shen, Marina W H, Zhang, Wen, Gonzalez, Mario, Liu, Shanghao, Mahadevan, Anu, Sard, Howard, Khor, Soo Peang, Clark, James D
Published in Journal of medicinal chemistry (12.01.2006)
Get full text
Published in Journal of medicinal chemistry (12.01.2006)
Journal Article
Inhibition of Cytosolic Phospholipase A 2 α: Hit to Lead Optimization
McKew, John C., Foley, Megan A., Thakker, Paresh, Behnke, Mark L., Lovering, Frank E., Sum, Fuk-Wah, Tam, Steve, Wu, Kun, Shen, Marina W. H., Zhang, Wen, Gonzalez, Mario, Liu, Shanghao, Mahadevan, Anu, Sard, Howard, Khor, Soo Peang, Clark, James D.
Published in Journal of medicinal chemistry (01.01.2006)
Published in Journal of medicinal chemistry (01.01.2006)
Get full text
Journal Article
A conformationally constrained competitive inhibitor of the sodium-dependent glutamate transporter in forebrain synaptosomes: l- anti-endo-3,4-methanopyrrolidine dicarboxylate
Bridges, Richard J., Lovering, Frank E., Koch, Hans, Cotman, Carl W., Chamberlin, A.Richard
Published in Neuroscience letters (20.06.1994)
Published in Neuroscience letters (20.06.1994)
Get full text
Journal Article
Identification of Potent and Selective MMP-13 Inhibitors
Wu, Junjun, Rush, Thomas S. III, Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.
Published in ChemInform (06.12.2005)
Published in ChemInform (06.12.2005)
Get full text
Journal Article