Investigation of Functionally Liver Selective Glucokinase Activators for the Treatment of Type 2 Diabetes
Bebernitz, Gregory R, Beaulieu, Valerie, Dale, Bethany A, Deacon, Richard, Duttaroy, Alokesh, Gao, Jiaping, Grondine, Melissa S, Gupta, Ramesh C, Kakmak, Mesut, Kavana, Michael, Kirman, Louise C, Liang, Jinsheng, Maniara, Wieslawa M, Munshi, Siralee, Nadkarni, Sunil S, Schuster, Herbert F, Stams, Travis, St. Denny, Irene, Taslimi, Paul M, Vash, Brian, Caplan, Shari L
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
Get full text
Journal Article
Avoidance of the Ames test liability for aryl–amines via computation
McCarren, Patrick, Bebernitz, Gregory R., Gedeck, Peter, Glowienke, Susanne, Grondine, Melissa S., Kirman, Louise C., Klickstein, Jacob, Schuster, Herbert F., Whitehead, Lewis
Published in Bioorganic & medicinal chemistry (15.05.2011)
Published in Bioorganic & medicinal chemistry (15.05.2011)
Get full text
Journal Article
Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach
Lorthiois, Edwige, Roache, James, Barnes-Seeman, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri G, Schiering, Nikolaus, Weihofen, Wilhelm A, Perruccio, Francesca, Calhoun, Amy, Fazal, Tanzina, Dedic, Darija, Durand, Corinne, Dussauge, Solene, Fettis, Kamal, Tritsch, Fabien, Dentel, Celine, Druet, Adelaide, Liu, Donglei, Kirman, Louise, Lachal, Julie, Namoto, Kenji, Bevan, Douglas, Mo, Rose, Monnet, Gabriela, Muller, Lionel, Zessis, Richard, Huang, Xueming, Lindsley, Loren, Currie, Treeve, Chiu, Yu-Hsin, Fridrich, Cary, Delgado, Peter, Wang, Shuangxi, Hollis-Symynkywicz, Micah, Berghausen, Joerg, Williams, Eric, Liu, Hong, Liang, Guiqing, Kim, Hyungchul, Hoffmann, Peter, Hein, Andreas, Ramage, Paul, D’Arcy, Allan, Harlfinger, Stefanie, Renatus, Martin, Ruedisser, Simon, Feldman, David, Elliott, Jason, Sedrani, Richard, Maibaum, Juergen, Adams, Christopher M
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
Get full text
Journal Article
Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists
Thomson, Christopher G., Boss, Kelly, Calhoun, Amy, Fridrich, Cary, Gardinier, Kevin M., Hall, Edward C., Jendza, Keith, Kirman, Louise, Labbé-Giguere, Nancy, Laumen, Kurt, Qian, Ming, Sanyal, Sanjit, Shultz, Michael D., Snajdrova, Radka, Tan, Kian, Wang, Kate Yaping, Yang, Fan, Gao, Feng, Hong, Tao, Dale, Elena, Kuzmiski, Brent, Ortuno, Danny, Palacios, Daniel S.
Published in ACS medicinal chemistry letters (14.12.2023)
Published in ACS medicinal chemistry letters (14.12.2023)
Get full text
Journal Article
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway
Bruce, Ian, Akhlaq, Mohammed, Bloomfield, Graham C., Budd, Emma, Cox, Brian, Cuenoud, Bernard, Finan, Peter, Gedeck, Peter, Hatto, Julia, Hayler, Judy F., Head, Denise, Keller, Thomas, Kirman, Louise, Leblanc, Catherine, Grand, Darren Le, McCarthy, Clive, O’Connor, Desmond, Owen, Charles, Oza, Mrinalini S., Pilgrim, Gaynor, Press, Nicola E., Sviridenko, Lilya, Whitehead, Lewis
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Get full text
Journal Article
CDK2 inhibitors and methods of using the same
Feutrill, John, Michowski, Wojtek, Porter, Jr., Dale A, Kirman, Louise Clare, Schwartz, Carl Eric, Ripper, Justin
Year of Publication 06.08.2024
Get full text
Year of Publication 06.08.2024
Patent
TEAD INHIBITORS AND USES THEREOF
SCHWARTZ, C. Eric, RENNIE, Glen Robert, KIRMAN, Louise, PORTER, Dale, SONG, Ling
Year of Publication 07.02.2024
Get full text
Year of Publication 07.02.2024
Patent
CDK2 INHIBITORS AND METHODS OF USING THE SAME
PORTER, JR., Dale A, RIPPER, Justin, KIRMAN, Louise Clare, SCHWARTZ, Carl Eric, FEUTRILL, John, MICHOWSKI, Wojtek
Year of Publication 01.05.2024
Get full text
Year of Publication 01.05.2024
Patent
TEAD INHIBITORS AND USES THEREOF
Kirman, Louise, Song, Ling, Rennie, Glen Robert, Porter, Dale, Schwartz, C. Eric
Year of Publication 13.04.2023
Get full text
Year of Publication 13.04.2023
Patent