Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth
Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Vernal, Javier, Villarino, Andrea, Guido, Rafael V.C., Perizzolo, Paulo, Poirier, Valerie, Wong, Dennis, Martins, Priscila Graziela Alves, Nunes, Ricardo José, Yunes, Rosendo Augusto, Andricopulo, Adriano Defini, Av-Gay, Yossef, Terenzi, Hernán
Published in Bioorganic & medicinal chemistry (01.06.2010)
Published in Bioorganic & medicinal chemistry (01.06.2010)
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Journal Article
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus
Moreira Osório, Thaís, Delle Monache, Franco, Domeneghini Chiaradia, Louise, Mascarello, Alessandra, Regina Stumpf, Taisa, Roberto Zanetti, Carlos, Bardini Silveira, Douglas, Regina Monte Barardi, Célia, de Fatima Albino Smânia, Elza, Viancelli, Aline, Ariel Totaro Garcia, Lucas, Augusto Yunes, Rosendo, José Nunes, Ricardo, Smânia, Artur
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs
Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Mori, Mattia, Terenzi, Hernán, Botta, Bruno
Published in Current pharmaceutical design (01.04.2016)
Published in Current pharmaceutical design (01.04.2016)
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Journal Article
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
DOMENEGHINI CHIARADIA, Louise, MASCARELLO, Alessandra, PURIFICACAO, Marcela, VERNAL, Javier, SECHINI CORDEIRO, Marlon Norberto, ZENTENO, Maria Emilia, VILLARINO, Andréa, NUNES, Ricardo José, YUNES, Rosendo Augusto, TERENZI, Hernan
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Journal Article
Antihyperglycemic activity of naphthylchalcones
Damazio, Rosangela Guollo, Zanatta, Ana Paula, Cazarolli, Luisa Helena, Chiaradia, Louise Domeneghini, Mascarello, Alessandra, Nunes, Ricardo José, Yunes, Rosendo Augusto, Barreto Silva, Fátima Regina Mena
Published in European journal of medicinal chemistry (01.04.2010)
Published in European journal of medicinal chemistry (01.04.2010)
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Journal Article
Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products
Mascarello, Alessandra, Mori, Mattia, Chiaradia-Delatorre, Louise Domeneghini, Menegatti, Angela Camila Orbem, Delle Monache, Franco, Ferrari, Franco, Yunes, Rosendo Augusto, Nunes, Ricardo José, Terenzi, Hernán, Botta, Bruno, Botta, Maurizio
Published in PloS one (14.10.2013)
Published in PloS one (14.10.2013)
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Journal Article
Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death
Winter, Evelyn, Chiaradia, Louise Domeneghini, de Cordova, Clarissa A.S., Nunes, Ricardo José, Yunes, Rosendo Augusto, Creczynski-Pasa, Tânia Beatriz
Published in Bioorganic & medicinal chemistry (15.11.2010)
Published in Bioorganic & medicinal chemistry (15.11.2010)
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Journal Article
Hydroxychalcones induce apoptosis in B16-F10 melanoma cells via GSH and ATP depletion
Formento Navarini, Andreia Lilian, Chiaradia, Louise Domeneghini, Mascarello, Alessandra, Fritzen, Marcio, Nunes, Ricardo Jose, Yunes, Rosendo Augusto, Creczynski-Pasa, Tania Beatriz
Published in European journal of medicinal chemistry (01.04.2009)
Published in European journal of medicinal chemistry (01.04.2009)
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Journal Article
Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure–activity relationships
Chiaradia, Louise Domeneghini, dos Santos, Rodrigo, Vitor, Carlos Eduardo, Vieira, André Alexandre, Leal, Paulo César, Nunes, Ricardo José, Calixto, João Batista, Yunes, Rosendo Augusto
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Journal Article
Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches
Ferreira, Natalia C, Marques, Icaro A, Conceição, Wesley A, Macedo, Bruno, Machado, Clarice S, Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Hughson, Andrew G, Raymond, Lynne D, Pascutti, Pedro G, Caughey, Byron, Cordeiro, Yraima
Published in PloS one (06.01.2014)
Published in PloS one (06.01.2014)
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Journal Article
A chalcone derivative binds a putative allosteric site of YopH: Inhibition of a virulence factor of Yersinia
de Souza, Ana C.A., Mori, Mattia, Sens, Larissa, Rocha, Ruth F., Tizziani, Tiago, de Souza, Luiz F.S., Domeneghini Chiaradia-Delatorre, Louise, Botta, Maurizio, Nunes, Ricardo J., Terenzi, Hernán, Menegatti, Angela C.O.
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
Published in Bioorganic & medicinal chemistry letters (15.08.2020)
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Journal Article
Chalcones to control Alternaria alternata in murcott tangor fruits
Camargos, Renato Barbosa, Perina, Fabiano José, Carvalho, Daniel Diego Costa, Alves, Eduardo, Mascarello, Alessandra, Chiaradia-Delatorre, Louise Domeneghini, Yunes, Rosendo Augusto, Nunes, Ricardo José, Oliveira, Denilson Ferreira
Published in Bioscience journal (01.11.2016)
Published in Bioscience journal (01.11.2016)
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Journal Article
Novel synthetic chalcones induces apoptosis in human glioblastoma cells
Bittencourt, Lucas Felipe Fernandes, Oliveira, Karen Andrinéia de, Cardoso, Carine Bropp, Lopes, Flávia Garcia, Dal-Cim, Tharine, Chiaradia-Delatorre, Louise Domeneghini, Mascarello, Alessandra, Maluf, Sharbel Weidner, Yunes, Rosendo Augusto, Garcez, Ricardo Castilho, Tasca, Carla Inês, Nedel, Cláudia Beatriz
Published in Chemico-biological interactions (25.05.2016)
Published in Chemico-biological interactions (25.05.2016)
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Journal Article
Involvement of extrinsic and intrinsic apoptotic pathways together with endoplasmic reticulum stress in cell death induced by naphthylchalcones in a leukemic cell line: Advantages of multi-target action
Winter, Evelyn, Chiaradia, Louise Domeneghini, Silva, Adny Henrique, Nunes, Ricardo José, Yunes, Rosendo Augusto, Creczynski-Pasa, Tânia Beatriz
Published in Toxicology in vitro (01.08.2014)
Published in Toxicology in vitro (01.08.2014)
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Journal Article
Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB)
Chiaradia, Louise Domeneghini, Martins, Priscila Graziela Alves, Cordeiro, Marlon Norberto Sechini, Guido, Rafael Victorio Carvalho, Ecco, Gabriela, Andricopulo, Adriano Defini, Yunes, Rosendo Augusto, Vernal, Javier, Nunes, Ricardo José, Terenzi, Hernán
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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Journal Article
Activity of novel quinoxaline-derived chalcones on in vitro glioma cell proliferation
Mielcke, Tânia R., Mascarello, Alessandra, Filippi-Chiela, Eduardo, Zanin, Rafael F., Lenz, Guido, Leal, Paulo César, Chirardia, Louise D., Yunes, Rosendo A., Nunes, Ricardo J., Battastini, Ana M.O., Morrone, Fernanda B., Campos, Maria M.
Published in European journal of medicinal chemistry (01.02.2012)
Published in European journal of medicinal chemistry (01.02.2012)
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Journal Article
Biochemical Evaluation of a Series of Synthetic Chalcone and Hydrazide Derivatives as Novel Inhibitors of Cruzain from Trypanosoma cruzi
Borchhardt, Deise M., Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Nunes, Ricardo J., Oliva, Glaucius, Yunes, Rosendo A., Andricopulo, Adriano D.
Published in Journal of the Brazilian Chemical Society (01.01.2010)
Published in Journal of the Brazilian Chemical Society (01.01.2010)
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Journal Article
Trimethoxy-chalcone derivatives inhibit growth of Leishmania braziliensis: Synthesis, biological evaluation, molecular modeling and structure–activity relationship (SAR)
Bello, Murilo Lamim, Chiaradia, Louise Domeneghini, Dias, Luiza Rosaria Sousa, Pacheco, Letícia Kramer, Stumpf, Taisa Regina, Mascarello, Alessandra, Steindel, Mário, Yunes, Rosendo Augusto, Castro, Helena Carla, Nunes, Ricardo José, Rodrigues, Carlos Rangel
Published in Bioorganic & medicinal chemistry (15.08.2011)
Published in Bioorganic & medicinal chemistry (15.08.2011)
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Journal Article
Apoptotic events induced by synthetic naphthylchalcones in human acute leukemia cell lines
Maioral, Mariana Franzoni, Gaspar, Pâmela Cristina, Rosa Souza, Gabriela Regina, Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Licínio, Marley Aparecida, Moraes, Ana Carolina Rabello, Yunes, Rosendo Augusto, Nunes, Ricardo José, Santos-Silva, Maria Cláudia
Published in Biochimie (01.04.2013)
Published in Biochimie (01.04.2013)
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Journal Article
Nitrochalcones: Potential in vivo insulin secretagogues
Damazio, Rosangela Guollo, Zanatta, Ana Paula, Cazarolli, Luisa Helena, Mascarello, Alessandra, Chiaradia, Louise Domeneghini, Nunes, Ricardo José, Yunes, Rosendo Augusto, Silva, Fátima Regina Mena Barreto
Published in Biochimie (01.11.2009)
Published in Biochimie (01.11.2009)
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