Lenalidomide downregulates the cell survival factor, interferon regulatory factor‐4, providing a potential mechanistic link for predicting response
Lopez‐Girona, Antonia, Heintel, Daniel, Zhang, Ling‐Hua, Mendy, Derek, Gaidarova, Svetlana, Brady, Helen, Bartlett, Justin Blake, Schafer, Peter H., Schreder, Martin, Bolomsky, Arnold, Hilgarth, Bernadette, Zojer, Niklas, Gisslinger, Heinz, Ludwig, Heinz, Daniel, Tom, Jäger, Ulrich, Chopra, Rajesh
Published in British journal of haematology (01.08.2011)
Published in British journal of haematology (01.08.2011)
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Journal Article
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity
Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Published in British journal of haematology (01.01.2014)
Published in British journal of haematology (01.01.2014)
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Journal Article
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E
Published in Nature structural & molecular biology (01.09.2014)
Published in Nature structural & molecular biology (01.09.2014)
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Journal Article
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells
Surka, Christine, Jin, Liqing, Mbong, Nathan, Lu, Chin-Chun, Jang, In Sock, Rychak, Emily, Mendy, Derek, Clayton, Thomas, Tindall, Elizabeth, Hsu, Christy, Fontanillo, Celia, Tran, Eileen, Contreras, Adrian, Ng, Stanley W.K., Matyskiela, Mary, Wang, Kai, Chamberlain, Philip, Cathers, Brian, Carmichael, James, Hansen, Joshua, Wang, Jean C.Y., Minden, Mark D., Fan, Jinhong, Pierce, Daniel W., Pourdehnad, Michael, Rolfe, Mark, Lopez-Girona, Antonia, Dick, John E., Lu, Gang
Published in Blood (04.02.2021)
Published in Blood (04.02.2021)
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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL
Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Published in Blood (06.08.2015)
Published in Blood (06.08.2015)
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Journal Article
The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
Ferguson, Ian D, Patiño-Escobar, Bonell, Tuomivaara, Sami T, Lin, Yu-Hsiu T, Nix, Matthew A, Leung, Kevin K, Kasap, Corynn, Ramos, Emilio, Nieves Vasquez, Wilson, Talbot, Alexis, Hale, Martina, Naik, Akul, Kishishita, Audrey, Choudhry, Priya, Lopez-Girona, Antonia, Miao, Weili, Wong, Sandy W, Wolf, Jeffrey L, Martin, 3rd, Thomas G, Shah, Nina, Vandenberg, Scott, Prakash, Sonam, Besse, Lenka, Driessen, Christoph, Posey, Jr, Avery D, Mullins, R Dyche, Eyquem, Justin, Wells, James A, Wiita, Arun P
Published in Nature communications (15.07.2022)
Published in Nature communications (15.07.2022)
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An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme
Ceccarelli, Derek F., Tang, Xiaojing, Pelletier, Benoit, Orlicky, Stephen, Xie, Weilin, Plantevin, Veronique, Neculai, Dante, Chou, Yang-Chieh, Ogunjimi, Abiodun, Al-Hakim, Abdallah, Varelas, Xaralabos, Koszela, Joanna, Wasney, Gregory A., Vedadi, Masoud, Dhe-Paganon, Sirano, Cox, Sarah, Xu, Shuichan, Lopez-Girona, Antonia, Mercurio, Frank, Wrana, Jeff, Durocher, Daniel, Meloche, Sylvain, Webb, David R., Tyers, Mike, Sicheri, Frank
Published in Cell (24.06.2011)
Published in Cell (24.06.2011)
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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma
Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia
Published in British journal of haematology (01.03.2016)
Published in British journal of haematology (01.03.2016)
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Journal Article
Targeting the p27 E3 ligase SCFSkp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy
Chen, Qing, Xie, Weilin, Kuhn, Deborah J., Voorhees, Peter M., Lopez-Girona, Antonia, Mendy, Derek, Corral, Laura G., Krenitsky, Veronique Plantevin, Xu, Weiming, Moutouh-de Parseval, Laure, Webb, David R., Mercurio, Frank, Nakayama, Keiichi I., Nakayama, Keiko, Orlowski, Robert Z.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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Journal Article
Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
VERHELLE, Dominique, CORRAL, Laura G, LOPEZ-GIRONA, Antonia, MUTTER, George W, BRADY, Helen A, CHAN, Kyle W. H, WONG, Kevin, MUELLER, Jessica H, MOUTOUH-DE PARSEVAL, Laure, JENSEN-PERGAKES, Kristen, SCHAFER, Peter H, CHEN, Roger, GLEZER, Emilia, FERGUSON, Gregory D
Published in Cancer research (Chicago, Ill.) (15.01.2007)
Published in Cancer research (Chicago, Ill.) (15.01.2007)
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Immunomodulatory drugs reorganize cytoskeleton by modulating Rho GTPases
Xu, Yibing, Li, Jianwu, Ferguson, Gregory D., Mercurio, Frank, Khambatta, Gody, Morrison, Lisa, Lopez-Girona, Antonia, Corral, Laura G., Webb, David R., Bennett, Brydon L., Xie, Weilin
Published in Blood (09.07.2009)
Published in Blood (09.07.2009)
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Journal Article
Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
Russell, Paul, Lopez-Girona, Antonia, Furnari, Beth, Mondesert, Odile
Published in Nature (London) (14.01.1999)
Published in Nature (London) (14.01.1999)
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Journal Article
A Dual Color Immunohistochemistry Assay for Measurement of Cereblon in Multiple Myeloma Patient Samples
Ren, Yan, Wang, Maria, Couto, Suzana, Hansel, Donna E, Miller, Karen, Lopez-Girona, Antonia, Bjorklund, Chad C, Gandhi, Anita K, Thakurta, Anjan, Chopra, Rajesh, Breider, Michael
Published in Applied immunohistochemistry & molecular morphology (01.11.2016)
Published in Applied immunohistochemistry & molecular morphology (01.11.2016)
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Journal Article
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21WAF1/Cip1-dependent mechanism independent of functional p53
Fecteau, Jessie-F., Corral, Laura G., Ghia, Emanuela M., Gaidarova, Svetlana, Futalan, Diahnn, Bharati, Ila Sri, Cathers, Brian, Schwaederlé, Maria, Cui, Bing, Lopez-Girona, Antonia, Messmer, Davorka, Kipps, Thomas J.
Published in Blood (04.09.2014)
Published in Blood (04.09.2014)
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2-이소인돌린-1,3-디온을 사용하여 만성 림프구성 백혈병을 치료하는 방법
KASIBHATLA SHAILAJA, POURDEHNAD MICHAEL, JANARDHANAN PREETHI, LOPEZ GIRONA ANTONIA
Year of Publication 25.07.2022
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Year of Publication 25.07.2022
Patent
Serine-345 is Required for Rad3-Dependent Phosphorylation and Function of Checkpoint Kinase Chk1 in Fission Yeast
Lopez-Girona, Antonia, Tanaka, Katsunori, Chen, Xiao-Bo, Baber, Beth A., McGowan, Clare H., Russell, Paul
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2001)
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2-이소인돌린-1,3-디온을 사용하여 비-호지킨 림프종을 치료하는 방법
NARLA RAMA KRISHNA, BUCHHOLZ TONIA J, ANTON MARIA SORAYA CARRANCIO, POURDEHNAD MICHAEL, LOPEZ GIRONA ANTONIA
Year of Publication 14.12.2021
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Year of Publication 14.12.2021
Patent
혈액암을 치료하는 방법 및 2-이소인돌린-1,3-디온에 대한 동반 바이오마커의 용도
FONTANILLO CELIA FONTANILLO, KASIBHATLA SHAILAJA, WANG KAI, ANTON MARIA SORAYA CARRANCIO, LU GANG, LOPEZ GIRONA ANTONIA
Year of Publication 25.07.2022
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Year of Publication 25.07.2022
Patent