Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
Lintner, Nathanael G, McClure, Kim F, Petersen, Donna, Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M, Maguire, Bruce, Geoghegan, Kieran F, Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A, Dullea, Robert G, Cate, Jamie H D
Published in PLoS biology (21.03.2017)
Published in PLoS biology (21.03.2017)
Get full text
Journal Article
Preparation of Heteroaryl Ethers from Azine N‑Oxides and Alcohols
Lian, Yajing, Coffey, Steven B, Li, Qifang, Londregan, Allyn T
Published in Organic letters (18.03.2016)
Published in Organic letters (18.03.2016)
Get full text
Journal Article
Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
Calabrese, Matthew F., Rajamohan, Francis, Harris, Melissa S., Caspers, Nicole L., Magyar, Rachelle, Withka, Jane M., Wang, Hong, Borzilleri, Kris A., Sahasrabudhe, Parag V., Hoth, Lise R., Geoghegan, Kieran F., Han, Seungil, Brown, Janice, Subashi, Timothy A., Reyes, Allan R., Frisbie, Richard K., Ward, Jessica, Miller, Russell A., Landro, James A., Londregan, Allyn T., Carpino, Philip A., Cabral, Shawn, Smith, Aaron C., Conn, Edward L., Cameron, Kimberly O., Qiu, Xiayang, Kurumbail, Ravi G.
Published in Structure (London) (05.08.2014)
Published in Structure (London) (05.08.2014)
Get full text
Journal Article
Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
Lintner, Nathanael G, McClure, Kim F, Petersen, Donna, Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing, Xiao, Jun, Bolt, Michael, Loria, Paula M, Maguire, Bruce, Geoghegan, Kieran F, Huang, Austin, Rolph, Tim, Liras, Spiros, Doudna, Jennifer A, Dullea, Robert G, Cate, Jamie H D
Published in PLoS biology (01.04.2018)
Published in PLoS biology (01.04.2018)
Get full text
Journal Article
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries
Londregan, Allyn T., Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Boehm, Markus, Carpino, Philip A., Chin, Janice E., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Get full text
Journal Article
Preparation of Azinones from (Cyclopropylmethoxy)azine Ethers
Londregan, Allyn T., Curto, John M., Hastry, Emma, Rose, Colin R., Berritt, Simon
Published in Journal of organic chemistry (05.05.2023)
Published in Journal of organic chemistry (05.05.2023)
Get full text
Journal Article
Structure and Inhibitor Binding Characterization of Oncogenic MLLT1 Mutants
Ni, Xiaomin, Londregan, Allyn T, Owen, Dafydd R, Knapp, Stefan, Chaikuad, Apirat
Published in ACS chemical biology (16.04.2021)
Published in ACS chemical biology (16.04.2021)
Get full text
Journal Article
Expedient Synthesis of α‑(2-Azaheteroaryl) Acetates via the Addition of Silyl Ketene Acetals to Azine‑N‑oxides
Londregan, Allyn T, Burford, Kristen, Conn, Edward L, Hesp, Kevin D
Published in Organic letters (20.06.2014)
Published in Organic letters (20.06.2014)
Get full text
Journal Article
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
Raux, Brigitt, Buchan, Karly A., Bennett, James, Christott, Thomas, Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Huber, Kilian V.M., Korczynska, Magdalena, Limberakis, Chris, Narayanan, Arjun, Owen, Dafydd R., Sáez, Laura Díaz, Stock, Ingrid A., Londregan, Allyn T.
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Get full text
Journal Article
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Futatsugi, Kentaro, Cabral, Shawn, Kung, Daniel W., Huard, Kim, Lee, Esther, Boehm, Markus, Bauman, Jonathan, Clark, Ronald W., Coffey, Steven B., Crowley, Collin, Dechert-Schmitt, Anne-Marie, Dowling, Matthew S., Dullea, Robert, Gosset, James R., Kalgutkar, Amit S., Kou, Kou, Li, Qifang, Lian, Yajing, Loria, Paula M., Londregan, Allyn T., Niosi, Mark, Orozco, Christine, Pettersen, John C., Pfefferkorn, Jeffrey A., Polivkova, Jana, Ross, Trenton T., Sharma, Raman, Stock, Ingrid A., Tesz, Gregory, Wisniewska, Hanna, Goodwin, Bryan, Price, David A.
Published in Journal of medicinal chemistry (24.11.2022)
Published in Journal of medicinal chemistry (24.11.2022)
Get full text
Journal Article
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, Varghese, Alison E.
Published in Journal of medicinal chemistry (12.01.2023)
Published in Journal of medicinal chemistry (12.01.2023)
Get full text
Journal Article
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups
Aspnes, Gary E., Coffey, Steven B., Darout, Etzer, Dechert-Schmitt, Anne-Marie, Dullea, Robert G., Kamlet, Adam S., Limberakis, Chris, Londregan, Allyn T., McClure, Kim F., Menhaji-Klotz, Elnaz, Piotrowski, David W., Polivkova, Jana, Raymer, Brian, Ruggeri, Roger B., Salatto, Christopher T., Tu, Meihua, Wei, Liuqing, Xiao, Jun
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Published in Bioorganic & medicinal chemistry letters (15.08.2023)
Get full text
Journal Article
Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents
Londregan, Allyn T, Wei, Liuqing, Xiao, Jun, Lintner, Nathanael G, Petersen, Donna, Dullea, Robert G, McClure, Kim F, Bolt, Michael W, Warmus, Joseph S, Coffey, Steven B, Limberakis, Chris, Genovino, Julien, Thuma, Benjamin A, Hesp, Kevin D, Aspnes, Gary E, Reidich, Benjamin, Salatto, Christopher T, Chabot, Jeffrey R, Cate, Jamie H. D, Liras, Spiros, Piotrowski, David W
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
Get full text
Journal Article
Synthesis of Pyridazine-Based α‑Helix Mimetics
Londregan, Allyn T, Piotrowski, David W, Wei, Liuqing
Published in ACS combinatorial science (10.10.2016)
Published in ACS combinatorial science (10.10.2016)
Get full text
Journal Article
Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7
Aspnes, Gary E., Menhaji-Klotz, Elnaz, Boehm, Markus, Londregan, Allyn T., Lee, Esther C.Y., Limberakis, Chris, Coffey, Steven B., Brown, Janice A., Jones, Rhys M., Hesp, Kevin D.
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Get full text
Journal Article
Expedient Synthesis of α‑Heteroaryl Piperidines Using a Pd‑Catalyzed Suzuki Cross-Coupling–Reduction Sequence
Hesp, Kevin D, Fernando, Dilinie P, Jiao, Wenhua, Londregan, Allyn T
Published in Organic letters (17.01.2014)
Published in Organic letters (17.01.2014)
Get full text
Journal Article