Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
Schoepfer, Joseph, Jahnke, Wolfgang, Berellini, Giuliano, Buonamici, Silvia, Cotesta, Simona, Cowan-Jacob, Sandra W, Dodd, Stephanie, Drueckes, Peter, Fabbro, Doriano, Gabriel, Tobias, Groell, Jean-Marc, Grotzfeld, Robert M, Hassan, A. Quamrul, Henry, Chrystèle, Iyer, Varsha, Jones, Darryl, Lombardo, Franco, Loo, Alice, Manley, Paul W, Pellé, Xavier, Rummel, Gabriele, Salem, Bahaa, Warmuth, Markus, Wylie, Andrew A, Zoller, Thomas, Marzinzik, Andreas L, Furet, Pascal
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1
Wylie, Andrew A., Schoepfer, Joseph, Jahnke, Wolfgang, Cowan-Jacob, Sandra W., Loo, Alice, Furet, Pascal, Marzinzik, Andreas L., Pelle, Xavier, Donovan, Jerry, Zhu, Wenjing, Buonamici, Silvia, Hassan, A. Quamrul, Lombardo, Franco, Iyer, Varsha, Palmer, Michael, Berellini, Giuliano, Dodd, Stephanie, Thohan, Sanjeev, Bitter, Hans, Branford, Susan, Ross, David M., Hughes, Timothy P., Petruzzelli, Lilli, Vanasse, K. Gary, Warmuth, Markus, Hofmann, Francesco, Keen, Nicholas J., Sellers, William R.
Published in Nature (London) (30.03.2017)
Published in Nature (London) (30.03.2017)
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Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state
Lombardo, Franco, Waters, Nigel J, Argikar, Upendra A, Dennehy, Michelle K, Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P, Berellini, Giuliano, Rajlic, Ivana Liric, Obach, R Scott
Published in Journal of clinical pharmacology (01.02.2013)
Published in Journal of clinical pharmacology (01.02.2013)
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Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance
Lombardo, Franco, Waters, Nigel J, Argikar, Upendra A, Dennehy, Michelle K, Zhan, Jenny, Gunduz, Mithat, Harriman, Shawn P, Berellini, Giuliano, Liric Rajlic, Ivana, Obach, R Scott
Published in Journal of clinical pharmacology (01.02.2013)
Published in Journal of clinical pharmacology (01.02.2013)
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ElogDoct: A Tool for Lipophilicity Determination in Drug Discovery. 2. Basic and Neutral Compounds
LOMBARDO, Franco, SHALAEVA, Marina Y., TUPPER, Karl A., GAO, Feng
Published in Journal of medicinal chemistry (19.07.2001)
Published in Journal of medicinal chemistry (19.07.2001)
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Antibacterial and Solubility Optimization of Thiomuracin A
LaMarche, Matthew J, Leeds, Jennifer A, Brewer, Jason, Dean, Karl, Ding, Jian, Dzink-Fox, Joanne, Gamber, Gabe, Jain, Akash, Kerrigan, Ryan, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, McKenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Robinson, Zachary, Schmitt, Esther, Stams, Travis, Tiamfook, Stacey, Yu, Donghui, Whitehead, Lewis
Published in Journal of medicinal chemistry (28.07.2016)
Published in Journal of medicinal chemistry (28.07.2016)
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Prediction of Volume of Distribution Values in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data
Lombardo, Franco, Obach, R. Scott, Shalaeva, Marina Y, Gao, Feng
Published in Journal of medicinal chemistry (20.06.2002)
Published in Journal of medicinal chemistry (20.06.2002)
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In silico ADME prediction: data, models, facts and myths
Lombardo, Franco, Gifford, Eric, Shalaeva, Marina Y
Published in Mini reviews in medicinal chemistry (01.12.2003)
Published in Mini reviews in medicinal chemistry (01.12.2003)
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In Silico Prediction of Volume of Distribution in Humans. Extensive Data Set and the Exploration of Linear and Nonlinear Methods Coupled with Molecular Interaction Fields Descriptors
Lombardo, Franco, Jing, Yankang
Published in Journal of chemical information and modeling (24.10.2016)
Published in Journal of chemical information and modeling (24.10.2016)
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Measurement of Dissociation Constants (pKa Values) of Organic Compounds by Multiplexed Capillary Electrophoresis Using Aqueous and Cosolvent BuffersAdvanced Analytical Technologies, Inc. (Formerly CombiSep), 2711 South Loop Drive, Suite 4200, Ames, IA 50010
Shalaeva, Marina, Kenseth, Jeremy, Lombardo, Franco, Bastin, Andrea
Published in Journal of pharmaceutical sciences (01.07.2008)
Published in Journal of pharmaceutical sciences (01.07.2008)
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In Silico Prediction of Ionization Constants of Drugs
Lee, Pil H, Ayyampalayam, Saravanaraj N, Carreira, Lionel A, Shalaeva, Marina, Bhattachar, Shobha, Coselmon, Rachel, Poole, Salwa, Gifford, Eric, Lombardo, Franco
Published in Molecular pharmaceutics (01.07.2007)
Published in Molecular pharmaceutics (01.07.2007)
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Computation of Brain−Blood Partitioning of Organic Solutes via Free Energy Calculations
Lombardo, Franco, Blake, James F, Curatolo, William J
Published in Journal of medicinal chemistry (22.11.1996)
Published in Journal of medicinal chemistry (22.11.1996)
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