Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
Silacci, Michela, Lembke, Wibke, Woods, Richard, Attinger-Toller, Isabella, Baenziger-Tobler, Nadja, Batey, Sarah, Santimaria, Roger, von der Bey, Ulrike, Koenig-Friedrich, Susann, Zha, Wenjuan, Schlereth, Bernd, Locher, Mathias, Bertschinger, Julian, Grabulovski, Dragan
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G
Preithner, Susanne, Elm, Stefanie, Lippold, Sandra, Locher, Mathias, Wolf, Andreas, Silva, Antonio J. da, Baeuerle, Patrick A., Prang, Nadja S.
Published in Molecular Immunology (01.03.2006)
Published in Molecular Immunology (01.03.2006)
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Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3
SCHLERETH, Bernd, KLEINDIENST, Petra, KUFER, Peter, BAEUERLE, Patrick A, FICHTNER, Iduna, LORENCZEWSKI, Grit, BRISCHWEIN, Klaus, LIPPOLD, Sandra, DA SILVA, Antonio, LOCHER, Mathias, KISCHEL, Roman, LUTTERBIISE, Ralf
Published in Cancer Immunology, Immunotherapy (01.07.2006)
Published in Cancer Immunology, Immunotherapy (01.07.2006)
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Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class
Brischwein, Klaus, Parr, Larissa, Pflanz, Stefan, Volkland, Jörg, Lumsden, John, Klinger, Matthias, Locher, Mathias, Hammond, Scott A, Kiener, Peter, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick A
Published in Journal of immunotherapy (1997) (01.11.2007)
Published in Journal of immunotherapy (1997) (01.11.2007)
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MT110: A novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors
Brischwein, Klaus, Schlereth, Bernd, Guller, Benjamin, Steiger, Carola, Wolf, Andreas, Lutterbuese, Ralf, Offner, Sonja, Locher, Mathias, Urbig, Thomas, Raum, Tobias, Kleindienst, Petra, Wimberger, Pauline, Kimmig, Rainer, Fichtner, Iduna, Kufer, Peter, Hofmeister, Robert, da Silva, Antonio J., Baeuerle, Patrick A.
Published in Molecular Immunology (01.03.2006)
Published in Molecular Immunology (01.03.2006)
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N-Glucuronidation of the antiepileptic drug retigabine: results from studies with human volunteers, heterologously expressed human UGTs, human liver, kidney, and liver microsomal membranes of Crigler-Najjar type II
Borlak, Jürgen, Gasparic, Antje, Locher, Mathias, Schupke, Hubert, Hermann, Robert
Published in Metabolism, clinical and experimental (01.06.2006)
Published in Metabolism, clinical and experimental (01.06.2006)
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Nonclinical safety testing of biopharmaceuticals – Addressing current challenges of these novel and emerging therapies
Brennan, Frank R., Baumann, Andreas, Blaich, Guenter, de Haan, Lolke, Fagg, Rajni, Kiessling, Andrea, Kronenberg, Sven, Locher, Mathias, Milton, Mark, Tibbitts, Jay, Ulrich, Peter, Weir, Lucinda
Published in Regulatory toxicology and pharmacology (01.10.2015)
Published in Regulatory toxicology and pharmacology (01.10.2015)
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New challenges and opportunities in nonclinical safety testing of biologics
Baumann, Andreas, Flagella, Kelly, Forster, Roy, de Haan, Lolke, Kronenberg, Sven, Locher, Mathias, Richter, Wolfgang F., Theil, Frank-Peter, Todd, Marque
Published in Regulatory toxicology and pharmacology (01.07.2014)
Published in Regulatory toxicology and pharmacology (01.07.2014)
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Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells
d’Argouges, Sandrine, Wissing, Sandra, Brandl, Christian, Prang, Nadja, Lutterbuese, Ralf, Kozhich, Alex, Suzich, JoAnn, Locher, Mathias, Kiener, Peter, Kufer, Peter, Hofmeister, Robert, Baeuerle, Patrick A, Bargou, Ralf C
Published in Leukemia research (01.03.2009)
Published in Leukemia research (01.03.2009)
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A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients
Oberneder, Ralf, Weckermann, Dorothea, Ebner, Beatrice, Quadt, Cornelia, Kirchinger, Petra, Raum, Tobias, Locher, Mathias, Prang, Nadja, Baeuerle, Patrick A., Leo, Eugen
Published in European journal of cancer (1990) (01.10.2006)
Published in European journal of cancer (1990) (01.10.2006)
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A human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSF
Krinner, Eva-Maria, Raum, Tobias, Petsch, Silke, Bruckmaier, Sandra, Schuster, Ioana, Petersen, Laetitia, Cierpka, Ronny, Abebe, Derege, Mølhøj, Michael, Wolf, Andreas, Sørensen, Poul, Locher, Mathias, Baeuerle, Patrick A., Hepp, Julia
Published in Molecular immunology (01.02.2007)
Published in Molecular immunology (01.02.2007)
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Exchanging human Fcγ1 with murine Fcγ2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model
Lutterbuese, Petra, Brischwein, Klaus, Hofmeister, Robert, Crommer, Sandrine, Lorenczewski, Grit, Petersen, Laetitia, Lippold, Sandra, da Silva, Antonio, Locher, Mathias, Baeuerle, Patrick A., Schlereth, Bernd
Published in Cancer Immunology, Immunotherapy (01.04.2007)
Published in Cancer Immunology, Immunotherapy (01.04.2007)
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Exchanging human Fc[gamma]1 with murine Fc[gamma]2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model
Lutterbuese, Petra, Brischwein, Klaus, Hofmeister, Robert, Crommer, Sandrine, Lorenczewski, Grit, Petersen, Laetitia, Lippold, Sandra, da Silva, Antonio, Locher, Mathias, Baeuerle, Patrick A, Schlereth, Bernd
Published in Cancer immunology, immunotherapy (01.04.2007)
Published in Cancer immunology, immunotherapy (01.04.2007)
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Journal Article
Exchanging human Fcgamma1 with murine Fcgamma2a highly potentiates anti-tumor activity of anti-EpCAM antibody adecatumumab in a syngeneic mouse lung metastasis model
Lutterbuese, Petra, Brischwein, Klaus, Hofmeister, Robert, Crommer, Sandrine, Lorenczewski, Grit, Petersen, Laetitia, Lippold, Sandra, da Silva, Antonio, Locher, Mathias, Baeuerle, Patrick A, Schlereth, Bernd
Published in Cancer immunology, immunotherapy : CII (01.04.2007)
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Published in Cancer immunology, immunotherapy : CII (01.04.2007)
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Pharmacokinetic/pharmacodynamic modeling of luteinizing hormone (LH) suppression and LH surge delay by cetrorelix after single and multiple doses in healthy premenopausal women
Nagaraja, Nelamangala V, Pechstein, Birgit, Erb, Katharina, Klipping, Christine, Hermann, Robert, Locher, Mathias, Derendorf, Hartmut
Published in Journal of clinical pharmacology (01.03.2003)
Published in Journal of clinical pharmacology (01.03.2003)
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Intranasal loteprednol etabonate in healthy male subjects: pharmacokinetics and effects on endogenous cortisol
Hermann, Robert, Locher, Mathias, Siebert-Weigel, Marianne, LaVallee, Nicole, Derendorf, Hartmut, Hochhaus, Günther
Published in Journal of clinical pharmacology (01.05.2004)
Published in Journal of clinical pharmacology (01.05.2004)
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Pharmacokinetic-pharmacodynamic modeling of testosterone and luteinizing hormone suppression by cetrorelix in healthy volunteers
Pechstein, B, Nagaraja, N V, Hermann, R, Romeis, P, Locher, M, Derendorf, H
Published in Journal of clinical pharmacology (01.03.2000)
Published in Journal of clinical pharmacology (01.03.2000)
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