Search Results - "LOBBEN, PAUL, C" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

by Mennen, Steven M, Alhambra, Carolina, Allen, C. Liana, Barberis, Mario, Berritt, Simon, Brandt, Thomas A, Campbell, Andrew D, Castañón, Jesús, Cherney, Alan H, Christensen, Melodie, Damon, David B, Eugenio de Diego, J, García-Cerrada, Susana, García-Losada, Pablo, Haro, Rubén, Janey, Jacob, Leitch, David C, Li, Ling, Liu, Fangfang, Lobben, Paul C, MacMillan, David W. C, Magano, Javier, McInturff, Emma, Monfette, Sebastien, Post, Ronald J, Schultz, Danielle, Sitter, Barbara J, Stevens, Jason M, Strambeanu, Iulia I, Twilton, Jack, Wang, Ke, Zajac, Matthew A
Published in Organic process research & development (21.06.2019)

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Journal Article

Control Strategy for the Manufacture of Brivanib Alaninate, a Novel Pyrrolotriazine VEGFR/FGFR Inhibitor

Control Strategy for the Manufacture of Brivanib Alaninate, a Novel Pyrrolotriazine VEGFR/FGFR Inhibitor

by Lobben, Paul C, Barlow, Evan, Bergum, James S, Braem, Alan, Chang, Shih-Ying, Gibson, Frank, Kopp, Nathaniel, Lai, Chiajen, LaPorte, Thomas L, Leahy, David K, Müslehiddinoğlu, Jale, Quiroz, Fernando, Skliar, Dimitri, Spangler, Lori, Srivastava, Sushil, Wasser, Daniel, Wasylyk, John, Wethman, Robert, Xu, Zhongmin
Published in Organic process research & development (21.08.2015)

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Journal Article

Enabling Synthesis of Triple Reuptake Inhibitor (+)-BMS-820836, a Potential Therapeutic Agent for the Treatment of Depression

Enabling Synthesis of Triple Reuptake Inhibitor (+)-BMS-820836, a Potential Therapeutic Agent for the Treatment of Depression

by Lobben, Paul C, Amin, Rasidul, Chen, Bang-Chi, Cui, Wenge, Hu, Min, Isherwood, Matthew, Liu, Shuang, Nacro, Kassoum, Miles, Brandon, Mobele, Bingidimi, Olson, Richard E, Wang, Bei, Yang, Yuh-Lin, Zhao, Rulin
Published in Organic process research & development (15.01.2016)

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Journal Article

Evaluation of Chelation Effects Operative during Diastereoselective Addition of the Allylindium Reagent to 2- and 3-Hydroxycyclohexanones in Aqueous, Organic, and Mixed Solvent Systems

Evaluation of Chelation Effects Operative during Diastereoselective Addition of the Allylindium Reagent to 2- and 3-Hydroxycyclohexanones in Aqueous, Organic, and Mixed Solvent Systems

by Paquette, Leo A, Lobben, Paul C
Published in Journal of organic chemistry (07.08.1998)

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Journal Article

π-Facial Diastereoselection in the 1,2-Addition of Allylmetal Reagents to 2-Methoxycyclohexanone and Tetrahydrofuranspiro-(2-cyclohexanone)

π-Facial Diastereoselection in the 1,2-Addition of Allylmetal Reagents to 2-Methoxycyclohexanone and Tetrahydrofuranspiro-(2-cyclohexanone)

by Paquette, Leo A, Lobben, Paul C
Published in Journal of the American Chemical Society (28.02.1996)

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Journal Article

Integrated Approach to the Development and Understanding of the Borane Reduction of a Carboxylic Acid

Integrated Approach to the Development and Understanding of the Borane Reduction of a Carboxylic Acid

by Lobben, Paul C, Leung, Simon Shun-Wang, Tummala, Srinivas
Published in Organic process research & development (01.11.2004)

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Journal Article

Allylindation of 6-Substituted 2-Hydroxy-1-tetralones in Aqueous and Organic Media. Stereochemistry and Competition Studies

Allylindation of 6-Substituted 2-Hydroxy-1-tetralones in Aqueous and Organic Media. Stereochemistry and Competition Studies

by Lobben, Paul C, Paquette, Leo A
Published in Journal of organic chemistry (02.10.1998)

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Journal Article

Enantioselective synthesis of BMS-911278: a triple reuptake inhibitor

Enantioselective synthesis of BMS-911278: a triple reuptake inhibitor

by Li, Jianqing, Smith, Daniel, Krishnananthan, Subramaniam, Wu, Dauh-Rurng, Sun, Dawn, Li, Peng, Ryan, Kristen, Hu, Min, Cui, Wenge, Naginskaya, Jennifer, Liu, Shuang, Lobben, Paul C., Ng, Alicia T., Olson, Richard, Mathur, Arvind
Published in Tetrahedron: asymmetry (15.01.2017)

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Journal Article

Methods for the preparation of pyrrolotriazine compounds

Methods for the preparation of pyrrolotriazine compounds

by LOBBEN PAUL C
Year of Publication 17.03.2009

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Patent

Methods for the preparation of pyrrolotriazine compounds

Methods for the preparation of pyrrolotriazine compounds

by Lobben, Paul C
Year of Publication 17.03.2009

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Patent

Methods for the preparation of pyrrolotriazine compounds

Methods for the preparation of pyrrolotriazine compounds

by LOBBEN PAUL C
Year of Publication 09.02.2006

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Patent

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

by GONZALEZ-BOBES FRANCISCO, ENGSTROM JOSHUA, LOBBEN PAUL C, ZHU JASON J, CONLON DAVID ALAN, FAN YU, BURT JUSTIN LOCKHEART, WEI CAROLYN S
Year of Publication 28.01.2016

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Patent

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

by ZHU, JASON J, CONLON, DAVID ALAN, WEI, CAROLYN S, GONZALEZ-BOBES, FRANCISCO, FAN, YU, LOBBEN, PAUL C, BURT, JUSTIN LOCKHEART, ENGSTROM, JOSHUA
Year of Publication 20.11.2014

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Patent

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

PROCESSES FOR PREPARING TETRAHYDROISOQUINOLINES

by ZHU, JASON J, CONLON, DAVID ALAN, WEI, CAROLYN S, GONZALEZ-BOBES, FRANCISCO, FAN, YU, LOBBEN, PAUL C, BURT, JUSTIN LOCKHEART, ENGSTROM, JOSHUA
Year of Publication 02.10.2014

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Patent

Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

Process for the preparation of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide

by Eastgate Martin D, Hay Michael Bryan, Zhu Keming, Xiao Yi, Wei Carolyn S, Desai Lopa V, Regens Christopher S, Fitzgerald Monica, Rosner Thorsten, Beutner Gregory L, Zheng Bin, Strotman Neil, Cuniere Nicolas, Cohen Benjamin, Lawler Michael Joseph, Lobben Paul C, Gao Qi
Year of Publication 13.12.2016

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Patent

PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE

PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE

by Eastgate Martin D, Hay Michael Bryan, Zhu Keming, Xiao Yi, Wei Carolyn S, Desai Lopa V, Regens Christopher S, Fitzgerald Monica, Rosner Thorsten, Beutner Gregory L, Zheng Bin, Strotman Neil, Cuniere Nicolas, Cohen Benjamin, Lawler Michael Joseph, Lobben Paul C, Gao Qi
Year of Publication 11.08.2016

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Patent

PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE

PROCESS FOR THE PREPARATION OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-1,6-DIHYDROIMIDAZO[4,5-d]PYRROLO[2,3-b]PYRIDINE-7-CARBOXAMIDE

by BEUTNER, GREGORY, L, LOBBEN, PAUL, C, EASTGATE, MARTIN, D, XIAO, YI, COHEN, BENJAMIN, ROSNER, THORSTEN, HAY, MICHAEL, BRYAN, GAO, QI, REGENS, CHRISTOPHER, S, LAWLER, MICHAEL, JOSEPH, WEI, CAROLYN, S, FITZGERALD, MONICA, STROTMAN, NEIL, ZHU, KEMING, DESAI, LOPA, V, CUNIERE, NICOLAS, ZHENG, BIN
Year of Publication 05.03.2015

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Patent

PROCESS FOR THE PREPARATION OF Y(1R), 2S -2-AMINOPROPIONIC ACID 2-Y4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOY2,1-f Y1,2,4 TRIAZIN-6-YLOXY -1-METHYLETHYL ESTER

PROCESS FOR THE PREPARATION OF Y(1R), 2S -2-AMINOPROPIONIC ACID 2-Y4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOY2,1-f Y1,2,4 TRIAZIN-6-YLOXY -1-METHYLETHYL ESTER

by LEAHY DAVID K, LOBBEN PAUL C, THORNTON JOHN E, MUSLEHIDDINOGLU JALE, HAMEDI MOURAD, XU ZHONGMIN, DISCORDIA ROBERT P, LAI CHIAJEN, CRISPINO GERARD A, PESTI JAAN A, SPANGLER LORI ANN, LAPORTE THOMAS L
Year of Publication 28.06.2013

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Patent

PROCESS FOR THE PREPARATION OF Ý(1R), 2S¨-2-AMINOPROPIONIC ACID 2-Ý4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOÝ2,1-f¨Ý1,2,4¨TRIAZIN-6-YLOXY¨-1-METHYLETHYL ESTER

PROCESS FOR THE PREPARATION OF Ý(1R), 2S¨-2-AMINOPROPIONIC ACID 2-Ý4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLOÝ2,1-f¨Ý1,2,4¨TRIAZIN-6-YLOXY¨-1-METHYLETHYL ESTER

by LAPORTE, THOMAS L, LEAHY, DAVID K, MUSLEHIDDINOGLU, JALE, LAI, CHIAJEN, CRISPINO, GERARD A, LOBBEN, PAUL C, DISCORDIA, ROBERT P, PESTI, JAAN A, HAMEDI, MOURAD, THORNTON, JOHN E, XU, ZHONGMIN, SPANGLER, LORI ANN
Year of Publication 30.04.2013

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Patent

PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO]2,1-f-[1,2,4-TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER

PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO]2,1-f-[1,2,4-TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER

by LAPORTE, THOMAS L, LEAHY, DAVID K, MUSLEHIDDINOGLU, JALE, LAI, CHIAJEN, CRISPINO, GERARD A, LOBBEN, PAUL C, DISCORDIA, ROBERT P, PESTI, JAAN A, HAMEDI, MOURAD, THORNTON, JOHN E, XU, ZHONGMIN, SPANGLER, LORI ANN
Year of Publication 31.03.2013

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Patent