Overcoming resistance to immune checkpoint therapy in PTEN-null prostate cancer by intermittent anti-PI3Kα/β/δ treatment
Qi, Zhi, Xu, Zihan, Zhang, Liuzhen, Zou, Yongkang, Li, Jinping, Yan, Wenyu, Li, Cheng, Liu, Ningshu, Wu, Hong
Published in Nature communications (10.01.2022)
Published in Nature communications (10.01.2022)
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T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1
Zhu, Haichuan, Zhang, Liuzhen, Wu, Yilin, Dong, Bingjie, Guo, Weilong, Wang, Mei, Yang, Lu, Fan, Xiaoying, Tang, Yuliang, Liu, Ningshu, Lei, Xiaoguang, Wu, Hong
Published in eLife (09.11.2018)
Published in eLife (09.11.2018)
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Dual targeting non-overlapping epitopes in HER2 domain IV substantially enhanced HER2/HER2 homodimers and HER2/EGFR heterodimers internalization leading to potent antitumor activity in HER2-positive human gastric cancer
Wei, Ruicheng, Zhang, Wenli, Yang, Futang, Li, Qianhao, Wang, Qingyu, Liu, Ningshu, Zhu, Jun, Shan, Yongqiang
Published in Journal of translational medicine (09.07.2024)
Published in Journal of translational medicine (09.07.2024)
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Retraction Note: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT
Hill, Richard, Madureira, Patricia A, Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaҫo, Laura, Dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O, Link, Wolfgang
Published in Nature communications (19.07.2023)
Published in Nature communications (19.07.2023)
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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946)
Scott, William J., Hentemann, Martin F., Rowley, R. Bruce, Bull, Cathy O., Jenkins, Susan, Bullion, Ann M., Johnson, Jeffrey, Redman, Anikó, Robbins, Arthur H., Esler, William, Fracasso, R. Paul, Garrison, Timothy, Hamilton, Mark, Michels, Martin, Wood, Jill E., Wilkie, Dean P., Xiao, Hong, Levy, Joan, Stasik, Enrico, Liu, Ningshu, Schaefer, Martina, Brands, Michael, Lefranc, Julien
Published in ChemMedChem (19.07.2016)
Published in ChemMedChem (19.07.2016)
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Acetyl-CoA carboxylase inhibitors attenuate WNT and Hedgehog signaling and suppress pancreatic tumor growth
Petrova, Elissaveta, Scholz, Arne, Paul, Juliane, Sturz, Andrea, Haike, Katja, Siegel, Franziska, Mumberg, Dominik, Liu, Ningshu
Published in Oncotarget (25.07.2017)
Published in Oncotarget (25.07.2017)
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Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses
Heller, Simon, Glaeske, Sarah, Gluske, Katja, Paul, Juliane, Böhme, Annika, Janzer, Andreas, Roider, Helge Gottfried, Montebaur, Anna, Nicke, Barbara, Lesche, Ralf, von Ahsen, Oliver, Politz, Oliver, Liu, Ningshu, Gorjánácz, Mátyás
Published in Clinical and experimental medicine (01.12.2023)
Published in Clinical and experimental medicine (01.12.2023)
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RETRACTED ARTICLE: TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT
Hill, Richard, Madureira, Patricia A., Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaço, Laura, dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O., Link, Wolfgang
Published in Nature communications (09.03.2017)
Published in Nature communications (09.03.2017)
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Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor
Pletz, Nadin, Schön, Margarete, Ziegelbauer, Karl, Emmert, Steffen, Liu, Ningshu, Dobbelstein, Matthias, Schön, Michael P.
Published in Experimental dermatology (01.04.2012)
Published in Experimental dermatology (01.04.2012)
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Simultaneous Inhibition of PI3Kδ and PI3Kα Induces ABC-DLBCL Regression by Blocking BCR-Dependent and -Independent Activation of NF-κB and AKT
Paul, Juliane, Soujon, Maurice, Wengner, Antje M., Zitzmann-Kolbe, Sabine, Sturz, Andrea, Haike, Katja, Keng Magdalene, Koh Hui, Tan, Sze Huey, Lange, Martin, Tan, Soo Yong, Mumberg, Dominik, Lim, Soon Thye, Ziegelbauer, Karl, Liu, Ningshu
Published in Cancer cell (09.01.2017)
Published in Cancer cell (09.01.2017)
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BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models
Liu, Ningshu, Rowley, Bruce R, Bull, Cathy O, Schneider, Claudia, Haegebarth, Andrea, Schatz, Christoph A, Fracasso, Paul R, Wilkie, Dean P, Hentemann, Martin, Wilhelm, Scott M, Scott, William J, Mumberg, Dominik, Ziegelbauer, Karl
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling
Will, Marie, Qin, Alice Can Ran, Toy, Weiyi, Yao, Zhan, Rodrik-Outmezguine, Vanessa, Schneider, Claudia, Huang, Xiaodong, Monian, Prashant, Jiang, Xuejun, de Stanchina, Elisa, Baselga, José, Liu, Ningshu, Chandarlapaty, Sarat, Rosen, Neal
Published in Cancer discovery (01.03.2014)
Published in Cancer discovery (01.03.2014)
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Cotargeting the Cell-Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ Inhibitor BAY1082439
Zou, Yongkang, Qi, Zhi, Guo, Weilong, Zhang, Liuzhen, Ruscetti, Marcus, Shenoy, Tanu, Liu, Ningshu, Wu, Hong
Published in Molecular cancer therapeutics (01.10.2018)
Published in Molecular cancer therapeutics (01.10.2018)
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TRIB2 confers resistance to anti-cancer therapy by activating the serine/threonine protein kinase AKT
Hill, Richard, Madureira, Patricia A, Ferreira, Bibiana, Baptista, Inês, Machado, Susana, Colaço, Laura, Dos Santos, Marta, Liu, Ningshu, Dopazo, Ana, Ugurel, Selma, Adrienn, Angyal, Kiss-Toth, Endre, Isbilen, Murat, Gure, Ali O, Link, Wolfgang
Published in Nature communications (09.03.2017)
Published in Nature communications (09.03.2017)
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Co-Targeting the Cell Intrinsic and Microenvironment Pathways of Prostate Cancer by PI3Kα/β/δ inhibitor BAY1082439
Zou, Yongkang, Qi, Zhi, Guo, Weilong, Zhang, Liuzhen, Ruscetti, Marcus, Shenoy, Tanu, Liu, Ningshu, Wu, Hong
Published in Molecular cancer therapeutics (25.07.2018)
Published in Molecular cancer therapeutics (25.07.2018)
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BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling‐dependent tumor growth in mouse models
Politz, Oliver, Siegel, Franziska, Bärfacker, Lars, Bömer, Ulf, Hägebarth, Andrea, Scott, William J., Michels, Martin, Ince, Stuart, Neuhaus, Roland, Meyer, Kirstin, Fernández‐Montalván, Amaury Ernesto, Liu, Ningshu, von Nussbaum, Franz, Mumberg, Dominik, Ziegelbauer, Karl
Published in International journal of cancer (15.01.2017)
Published in International journal of cancer (15.01.2017)
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Abstract 1722: Hedgehog and Wnt crosstalk in pancreatic cancer
Petrova, Elissaveta, Scholz, Arne, Paul, Juliane, Sturz, Andrea, Haike, Katja, Siegel, Franziska, Mumberg, Dominik, Liu, Ningshu
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Efficacy of phosphatidylinositol‐3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells
Göckeritz, Elisa, Kerwien, Susan, Baumann, Michael, Wigger, Marion, Vondey, Verena, Neumann, Lars, Landwehr, Thomas, Wendtner, Clemens M., Klein, Christian, Liu, Ningshu, Hallek, Michael, Frenzel, Lukas P., Krause, Günter
Published in International journal of cancer (01.11.2015)
Published in International journal of cancer (01.11.2015)
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Abstract LB-123: Pulsatile inhibition of PI3K converts immune suppression by Tregs and M2-TAM to anti-tumor immune response in animal models insensitive or resistant to the monotherapies of PI3K and checkpoint inhibitors
Glaeske, Sarah, Huebner, Franziska, Anurin, Anna, Janzer, Andreas, Zitzmann-Kolbe, Sabine, Paul, Juliane, Glaeske, Katja, Berndt, Sandra, Mumberg, Dominik, Gorjanacz, Matyas, Ziegelbauer, Karl, Kreft, Bertolt, Liu, Ningshu
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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