Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors
Wang, Eric, Mi, Xiaoli, Thompson, Meghan C, Montoya, Skye, Notti, Ryan Q, Afaghani, Jumana, Durham, Benjamin H, Penson, Alex, Witkowski, Matthew T, Lu, Sydney X, Bourcier, Jessie, Hogg, Simon J, Erickson, Caroline, Cui, Dan, Cho, Hana, Singer, Michael, Totiger, Tulasigeri M, Chaudhry, Sana, Geyer, Mark, Alencar, Alvaro, Linley, Adam J, Palomba, M. Lia, Coombs, Catherine C, Park, Jae H, Zelenetz, Andrew, Roeker, Lindsey, Rosendahl, Mary, Tsai, Donald E, Ebata, Kevin, Brandhuber, Barbara, Hyman, David M, Aifantis, Iannis, Mato, Anthony, Taylor, Justin, Abdel-Wahab, Omar
Published in The New England journal of medicine (24.02.2022)
Published in The New England journal of medicine (24.02.2022)
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Journal Article
New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Wilson, Leah J, Linley, Adam, Hammond, Dean E, Hood, Fiona E, Coulson, Judy M, MacEwan, David J, Ross, Sarah J, Slupsky, Joseph R, Smith, Paul D, Eyers, Patrick A, Prior, Ian A
Published in Cancer research (Chicago, Ill.) (01.01.2018)
Published in Cancer research (Chicago, Ill.) (01.01.2018)
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Journal Article
BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells
Arthur, Rachael, Wathen, Alexander, Lemm, Elizabeth A., Stevenson, Freda K., Forconi, Francesco, Linley, Adam J., Steele, Andrew J., Packham, Graham, Valle-Argos, Beatriz
Published in Cellular signalling (01.08.2022)
Published in Cellular signalling (01.08.2022)
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Journal Article
IL-4 enhances expression and function of surface IgM in CLL cells
Aguilar-Hernandez, Maria M., Blunt, Matthew D., Dobson, Rachel, Yeomans, Alison, Thirdborough, Stephen, Larrayoz, Marta, Smith, Lindsay D., Linley, Adam, Strefford, Jonathan C., Davies, Andrew, Johnson, Peter M.W., Savelyeva, Natalia, Cragg, Mark S., Forconi, Francesco, Packham, Graham, Stevenson, Freda K., Steele, Andrew J.
Published in Blood (16.06.2016)
Published in Blood (16.06.2016)
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Journal Article
Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
Linley, Adam J, Karydis, Laura I, Mondru, Anil K, D'Avola, Annalisa, Al Shmrany, Humood, Cicconi, Silvia, Griffin, Rebecca, Forconi, Francesco, Pettitt, Andrew R, Kalakonda, Nagesh, Rawstron, Andrew C, Hillmen, Peter, Steele, Andrew J, MacEwan, David J, Packham, Graham, Prior, Ian A, Slupsky, Joseph R
Published in Clinical cancer research (15.10.2021)
Published in Clinical cancer research (15.10.2021)
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Journal Article
The Helicase HAGE Expressed by Malignant Melanoma-Initiating Cells Is Required for Tumor Cell Proliferation in Vivo
Linley, Adam J., Mathieu, Morgan G., Miles, Amanda K., Rees, Robert C., McArdle, Stephanie E.B., Regad, Tarik
Published in The Journal of biological chemistry (20.04.2012)
Published in The Journal of biological chemistry (20.04.2012)
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Journal Article
Tumour-associated antigens: considerations for their use in tumour immunotherapy
Linley, Adam J., Ahmad, Murrium, Rees, Robert C.
Published in International journal of hematology (01.03.2011)
Published in International journal of hematology (01.03.2011)
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Journal Article
HAGE, a cancer/testis antigen expressed at the protein level in a variety of cancers
Mathieu, Morgan G, Linley, Adam J, Reeder, Stephen P, Badoual, Cécile, Tartour, Eric, Rees, Robert C, McArdle, Stéphanie E B
Published in Cancer immunity (11.01.2010)
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Published in Cancer immunity (11.01.2010)
Journal Article
Gene Editing of BTK in Acute Myeloid Leukaemia Using CRISPR-Cas9
Maerken, Melanie, MacEwan, David, Harper, Nicholas, Slupsky, Joseph R, Linley, Adam
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation
Yeomans, Alison, Thirdborough, Stephen M., Valle-Argos, Beatriz, Linley, Adam, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Ishfaq, Muhammad, Wagner, Simon D., Willis, Anne E., Steele, Andrew J., Stevenson, Freda K., Forconi, Francesco, Coldwell, Mark J., Packham, Graham
Published in Blood (28.01.2016)
Published in Blood (28.01.2016)
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Journal Article
Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders
Montoya, Skye, Bourcier, Jessie, Thompson, Meghan C., Noviski, Mark, Tan, May, Wang, Eric, Mi, Xiaoli, Brathaban, Nivetha, Barrientos Risso, Carla, Tsai, Daniel, Ye, Jordan, Jahn, Jacob, Pardo, Gabriel, Cabuhat, Lee, Notti, Ryan, Pardo, Alejandro, Affer, Maurizio, Yung, Stephanie, Luliano, James, Powers, Janine, Robbins, Daniel W, Nawaratne, Vindhya, Totiger, Tulasigeri M, Pena-Velasquez, Camila, Rhodes, Joanna M., Zelenetz, Andrew D., Roeker, Lindsey E., Lu, Hao, Linley, Adam, Mato, Anthony R., Abdel-Wahab, Omar, Taylor, Justin
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia
Blunt, Matthew D, Smith, Lindsay D, Linley, Adam, Strefford, Jonathan C, Johnson, Peter, Forconi, Francesco, Stevenson, Freda K., Packham, Graham, Steele, Andrew J
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK
Krysov, Sergey, Steele, Andrew J., Coelho, Vania, Linley, Adam, Sanchez Hidalgo, Marina, Carter, Matthew, Potter, Kathleen N., Kennedy, Benjamin, Duncombe, Andrew S., Ashton-Key, Margaret, Forconi, Francesco, Stevenson, Freda K., Packham, Graham
Published in Blood (13.11.2014)
Published in Blood (13.11.2014)
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Journal Article
Abstract LB-153: The helicase antigen (HAGE) promotes tumor cell proliferation via up-regulation of Ras protein signalling
McArdle, Stephanie E.B., Linley, Adam A.J, Mathieu, Morgan M.G, Miles, Amanda A.K, Regad, Tarik, Rees, Robert C.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Kinobead Profiling Reveals Reprogramming of B-cell Receptor Signaling in Response to Therapy Within Primary Chronic Lymphocytic Leukemia Cells
Linley, Adam J, Karydis, Laura, Mondru, Anil, D'avola, Annalisa, Cicconi, Silvia, Griffin, Rebecca, coni, Francesco, Pettitt, Andrew R, Kalakonda, Nagesh, Rawstron, Andy, Hillmen, Peter, Steele, Andrew J, Macewan, David J, Packham, Graham, Prior, Ian, Slupsky, Joseph
Published in bioRxiv (30.05.2020)
Published in bioRxiv (30.05.2020)
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