TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Yao, Zhan, Fenoglio, Silvia, Gao, Ding Cheng, Camiolo, Matthew, Stiles, Brendon, Lindsted, Trine, Schlederer, Michaela, Johns, Chris, Altorki, Nasser, Mittal, Vivek, Kenner, Lukas, Sordella, Raffaella
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Get full text
Journal Article
Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors
Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael
Published in Clinical cancer research (01.10.2017)
Published in Clinical cancer research (01.10.2017)
Get full text
Journal Article
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Safaric Tepes, Polona, Pal, Debjani, Lindsted, Trine, Ibarra, Ingrid, Lujambio, Amaia, Jimenez Sabinina, Vilma, Senturk, Serif, Miller, Madison, Korimerla, Navya, Huang, Jiahao, Glassman, Lawrence, Lee, Paul, Zeltsman, David, Hyman, Kevin, Esposito, Michael, Hannon, Gregory J, Sordella, Raffaella
Published in eLife (13.07.2021)
Published in eLife (13.07.2021)
Get full text
Journal Article
Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial
Montagut, Clara, Argilés, Guillem, Ciardiello, Fortunato, Poulsen, Thomas T, Dienstmann, Rodrigo, Kragh, Michael, Kopetz, Scott, Lindsted, Trine, Ding, Cliff, Vidal, Joana, Clausell-Tormos, Jenifer, Siravegna, Giulia, Sánchez-Martín, Francisco J, Koefoed, Klaus, Pedersen, Mikkel W, Grandal, Michael M, Dvorkin, Mikhail, Wyrwicz, Lucjan, Rovira, Ana, Cubillo, Antonio, Salazar, Ramon, Desseigne, Françoise, Nadal, Cristina, Albanell, Joan, Zagonel, Vittorina, Siena, Salvatore, Fumi, Guglielmo, Rospo, Giuseppe, Nadler, Paul, Horak, Ivan D, Bardelli, Alberto, Tabernero, Josep
Published in JAMA oncology (01.04.2018)
Published in JAMA oncology (01.04.2018)
Get more information
Journal Article
Abstract 5629: Preclinical characterization of Sym023 a human anti-TIM3 antibody with a novel mechanism of action
Lindsted, Trine, Gad, Monika, Grandal, Michael V., Frölich, Camilla, Bhatia, Vikram K., Gjetting, Torben, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Koefoed, Klaus, Pedersen, Mikkel W.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 5626: Preclinical characterization of Sym022, a novel anti-LAG3 antibody
Grandal, Michael M., Melander, Maria C., Bhatia, Vikram K., Gjetting, Torben, Lindsted, Trine, Fröhlich, Camilla, Lantto, Johan, Horak, Ivan D., Kragh, Michael, Kofoed, Klaus, Pedersen, Mikkel W.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Circulating tumor DNA profiling to identify patients with metastatic colorectal cancer with improved overall survival following Sym004 treatment
Poulsen, Thomas Tuxen, Kragh, Michael, Ding, Cliff, Pedersen, Mikkel W, Lindsted, Trine, Blondal, Thorarinn, Dienstmann, Rodrigo, Montagut, Clara, Horak, Ivan David, Kopetz, Scott, Tabernero, Josep
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
Get full text
Journal Article
Cetuximab Resistance in Squamous Carcinomas of the Upper Aerodigestive Tract Is Driven by Receptor Tyrosine Kinase Plasticity: Potential for mAb Mixtures
Kjær, Ida, Lindsted, Trine, Fröhlich, Camilla, Olsen, Jesper Velgaard, Horak, Ivan David, Kragh, Michael, Pedersen, Mikkel Wandahl
Published in Molecular cancer therapeutics (01.07.2016)
Published in Molecular cancer therapeutics (01.07.2016)
Get full text
Journal Article
항-FLT3 항체 및 조성물
LINDSTED TRINE, RIVA MATTEO, PEDERSEN MIKKEL WANDAHL, HANSEN RANDI WESTH, MELANDER EVA MARIA CARLSEN
Year of Publication 20.12.2022
Get full text
Year of Publication 20.12.2022
Patent
Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform
Gjetting, Torben, Gad, Monika, Fröhlich, Camilla, Lindsted, Trine, Melander, Maria C, Bhatia, Vikram K, Grandal, Michael M, Dietrich, Nikolaj, Uhlenbrock, Franziska, Galler, Gunther R, Strandh, Magnus, Lantto, Johan, Bouquin, Thomas, Horak, Ivan D, Kragh, Michael, Pedersen, Mikkel W, Koefoed, Klaus
Published in mAbs (19.05.2019)
Published in mAbs (19.05.2019)
Get full text
Journal Article
항-AXL 항체 및 조성물
WILLER ANTON, LINDSTED TRINE, HANSEN RANDI WESTH, GJETTING TORBEN, JAKOBSEN JANUS SCHOU, MELANDER EVA MARIA CARLSEN, WORSAAE ANNE
Year of Publication 04.11.2022
Get full text
Year of Publication 04.11.2022
Patent
Abstract 3585: HER3 and IGF1R are major mediators of both acquired and intrinsic cetuximab resistance in head and neck squamous cell carcinomas
Kjaer, Ida, Lindsted, Trine, Fröhlich, Camilla, Horak, Ivan D., Kragh, Michael, Olsen, Jesper V., Pedersen, Mikkel W.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 5455: Surface accumulation of receptor tyrosine kinases upon treatment with tyrosine kinase inhibitors and resulting enhancement of activity upon treatment cessation
Bjerregaard, Anne-Mette, Grandal, Michael V., Frohlich, Camilla, Lindsted, Trine, Egebjerg, Christina, Horac, Ivan D., Kragh, Michael, Pedersen, Mikkel W.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Get full text
Journal Article
Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single monoclonal antibody
Poulsen, Thomas T., Grandal, Michael M., Jacobsen, Helle J., Hansen, Dorte S., Lindsted, Trine, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Lantto, Johan
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
PD-1, TIM-3 및 LAG-3을 표적화하는 조합 요법
LINDSTED TRINE, FROEHLICH CAMILLA, GAD MONIKA, GRANDAL MICHAEL MONRAD, PEDERSEN MIKKEL WANDAHL, LANTTO JOHAN, HORAK IVAN DAVID, KRAGH MICHAEL, MELANDER EVA MARIA CARLSEN
Year of Publication 10.12.2019
Get full text
Year of Publication 10.12.2019
Patent
항-TIM-3 항체 및 조성물
KOEFOED KLAUS, BOUQUIN THOMAS, LINDSTED TRINE, GAD MONIKA, GRANDAL MICHAEL MONRAD, PEDERSEN MIKKEL WANDAHL, GJETTING TORBEN, HORAK IVAN DAVID, KRAGH MICHAEL, GALLER GUNTHER ROLAND
Year of Publication 14.12.2018
Get full text
Year of Publication 14.12.2018
Patent
TGF-[Beta] IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Yao, Zhan, Fenoglio, Silvia, Gao, Ding Cheng, Camiolo, Matthew, Stiles, Brendon, Lindsted, Trine, Schlederer, Michaela, Johns, Chris, Altorki, Nasser, Mittal, Vivek, Kenner, Lukas, Sordella, Raffaella
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (31.08.2010)
Journal Article
ANTI-FLT3 ANTIBODIES AND COMPOSITIONS
RIVA, Matteo, LINDSTED, Trine, MELANDER, Eva, Maria, Carlsen, HANSEN, Randi Westh, PEDERSEN, Mikkel, Wandahl
Year of Publication 22.02.2023
Get full text
Year of Publication 22.02.2023
Patent
Anti-AXL antibodies and compositions
Worsaae, Anne, Lindsted, Trine, Hansen, Randi Westh, Gjetting, Torben, Willer, Anton, Jakobsen, Janus Schou, Melander, Maria Carlsen
Year of Publication 07.11.2023
Get full text
Year of Publication 07.11.2023
Patent