Novel activators and small-molecule inhibitors of STAT3 in cancer
Yang, Lehe, Lin, Shichong, Xu, Lingyuan, Lin, Jiayuh, Zhao, Chengguang, Huang, Xiaoying
Published in Cytokine & growth factor reviews (01.10.2019)
Published in Cytokine & growth factor reviews (01.10.2019)
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Journal Article
Feedback Activation of STAT3 as a Cancer Drug-Resistance Mechanism
Zhao, Chengguang, Li, Huameng, Lin, Huey-Jen, Yang, Shulin, Lin, Jiayuh, Liang, Guang
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2016)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2016)
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Journal Article
Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy
Wu, Xiaojuan, Cao, Yang, Xiao, Hui, Li, Chenglong, Lin, Jiayuh
Published in Molecular cancer therapeutics (01.11.2016)
Published in Molecular cancer therapeutics (01.11.2016)
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Journal Article
Discovery of Novel STAT3 Small Molecule Inhibitors via in Silico Site-Directed Fragment-Based Drug Design
Yu, Wenying, Xiao, Hui, Lin, Jiayuh, Li, Chenglong
Published in Journal of medicinal chemistry (13.06.2013)
Published in Journal of medicinal chemistry (13.06.2013)
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Journal Article
Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface
Li, Huameng, Xiao, Hui, Lin, Li, Jou, David, Kumari, Vandana, Lin, Jiayuh, Li, Chenglong
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Journal Article
TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment
Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Doheny, Daniel, Zhu, Dongqin, Aguayo, Noah R., Xing, Fei, Chan, Michael, Ruiz, Jimmy, Metheny-Barlow, Linda J., Strowd, Roy, Lin, Jiayuh, Regua, Angelina T., Arrigo, Austin, Anguelov, Marlyn, Pasche, Boris, Debinski, Waldemar, Watabe, Kounosuke, Lo, Hui-Wen
Published in Oncogene (02.01.2020)
Published in Oncogene (02.01.2020)
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Journal Article
STAT3 Is Necessary for Proliferation and Survival in Colon Cancer―Initiating Cells
LI LIN, AIGUO LIU, ZHENGANG PENG, LIN, Huey-Jen, LI, Pui-Kai, CHENGLONG LI, JIAYUH LIN
Published in Cancer research (Chicago, Ill.) (01.12.2011)
Published in Cancer research (Chicago, Ill.) (01.12.2011)
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Journal Article
A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin
Zhang, Ruijie, Yang, Xiaozhi, Roque, Dana M, Li, Chenglong, Lin, Jiayuh
Published in PloS one (28.04.2021)
Published in PloS one (28.04.2021)
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Journal Article
LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer
Pan, Li, Chen, Xiang, Fu, Shengling, Yu, Wenying, Li, Chenglong, Wang, Tiffany, Lo, Hui-Wen, Lin, Jiayuh
Published in Breast cancer research and treatment (01.05.2020)
Published in Breast cancer research and treatment (01.05.2020)
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Journal Article
Inhibition of STAT3 Signaling Blocks the Anti-apoptotic Activity of IL-6 in Human Liver Cancer Cells
Liu, Yan, Li, Pui-Kai, Li, Chenglong, Lin, Jiayuh
Published in The Journal of biological chemistry (27.08.2010)
Published in The Journal of biological chemistry (27.08.2010)
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Journal Article
LLL12B, a small molecule STAT3 inhibitor, induces growth arrest, apoptosis, and enhances cisplatin-mediated cytotoxicity in medulloblastoma cells
Chen, Xiang, Pan, Li, Wei, Jia, Zhang, Ruijie, Yang, Xiaozhi, Song, Jinhua, Bai, Ren-Yuan, Fu, Shengling, Pierson, Christopher R., Finlay, Jonathan L., Li, Chenglong, Lin, Jiayuh
Published in Scientific reports (22.03.2021)
Published in Scientific reports (22.03.2021)
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Journal Article
Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy
Wei, Jia, Ma, Ling, Lai, Yi-Hui, Zhang, Ruijie, Li, Huameng, Li, Chenglong, Lin, Jiayuh
Published in Journal of experimental & clinical cancer research (08.02.2019)
Published in Journal of experimental & clinical cancer research (08.02.2019)
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Journal Article
Bazedoxifene exhibits growth suppressive activity by targeting interleukin‐6/glycoprotein 130/signal transducer and activator of transcription 3 signaling in hepatocellular carcinoma
Ma, Haiyan, Yan, Dan, Wang, Yina, Shi, Wei, Liu, Tianshu, Zhao, Chongqiang, Huo, Shengqi, Duan, Jialin, Tao, Jingwen, Zhai, Maocai, Luo, Pengcheng, Guo, Junyi, Tian, Lei, Mageta, Lulu, Jou, David, Zhang, Cuntai, Li, Chenglong, Lin, Jiayuh, Lv, Jiagao, Li, Sheng, Lin, Li
Published in Cancer science (01.03.2019)
Published in Cancer science (01.03.2019)
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Journal Article
Bazedoxifene Inhibits Cell Viability, Colony‐Forming Activity, and Cell Migration in Human Non–Small Cell Lung Cancer Cells and Improves the Treatment Efficacy of Paclitaxel and Gemcitabine
Huang, Yaochen, Lin, Jiayuh, Fu, Xiangning, Li, Lequn, Fu, Shenging
Published in The clinical respiratory journal (01.08.2024)
Published in The clinical respiratory journal (01.08.2024)
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Journal Article
Feedback activation of EGFR is the main cause for STAT3 inhibition-irresponsiveness in pancreatic cancer cells
Zhao, Chengguang, Yang, Lehe, Zhou, Feng, Yu, Yun, Du, Xiaojing, Xiang, Youqun, Li, Chenglong, Huang, Xiaoying, Xie, Congying, Liu, Zhiguo, Lin, Jiayuh, Wang, Liangxing, Liang, Guang, Cui, Ri
Published in Oncogene (14.05.2020)
Published in Oncogene (14.05.2020)
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Journal Article
CDK4/6 inhibitors in lung cancer: current practice and future directions
Lv, Shuoshuo, Yang, Jie, Lin, Jiayuh, Huang, Xiaoying, Zhao, Haiyang, Zhao, Chengguang, Yang, Lehe
Published in European respiratory review (31.01.2024)
Published in European respiratory review (31.01.2024)
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Journal Article
Bazedoxifene as a Potential Cancer Therapeutic Agent Targeting IL-6/GP130 Signaling
Shi, Changyou, Bopp, Taylor, Lo, Hui-Wen, Tkaczuk, Katherine, Lin, Jiayuh
Published in Current oncology (Toronto) (25.09.2024)
Published in Current oncology (Toronto) (25.09.2024)
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