Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances
Pirrone, Gregory F., Mathew, Rose M., Makarov, Alexey A., Bernardoni, Frank, Klapars, Artis, Hartman, Robert, Limanto, John, Regalado, Erik L.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (30.03.2018)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (30.03.2018)
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Journal Article
Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-b][1,2,4]triazine: Synthesis of an α2/ 3-Selective GABA Agonist
Gauthier, Donald R, Limanto, John, Devine, Paul N, Desmond, Richard A, Szumigala, Ronald H, Foster, Bruce S, Volante, R. P
Published in Journal of organic chemistry (22.07.2005)
Published in Journal of organic chemistry (22.07.2005)
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Journal Article
A multifunctional catalyst that stereoselectively assembles prodrugs
DiRocco, Daniel A., Ji, Yining, Sherer, Edward C., Klapars, Artis, Reibarkh, Mikhail, Dropinski, James, Mathew, Rose, Maligres, Peter, Hyde, Alan M., Limanto, John, Brunskill, Andrew, Ruck, Rebecca T., Campeau, Louis-Charles, Davies, Ian W.
Published in Science (American Association for the Advancement of Science) (28.04.2017)
Published in Science (American Association for the Advancement of Science) (28.04.2017)
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Journal Article
A Diastereoselective Method for the Construction of syn-2′-Deoxy-2′-fluoronucleosides
Pirnot, Michael T., Mao, Edna, Lam, Yu-hong, Limanto, John, Cohen, Ryan D., Chung, Cheol K., Phillips, Eric M.
Published in Organic letters (15.07.2022)
Published in Organic letters (15.07.2022)
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Journal Article
Multi-column ultra-high performance liquid chromatography screening with chaotropic agents and computer-assisted separation modeling enables process development of new drug substances
Haidar Ahmad, Imad A, Chen, Wenyong, Halsey, Holst M, Klapars, Artis, Limanto, John, Pirrone, Gregory F, Nowak, Timothy, Bennett, Raffeal, Hartman, Robert, Makarov, Alexey A, Mangion, Ian, Regalado, Erik L
Published in Analyst (London) (23.04.2019)
Published in Analyst (London) (23.04.2019)
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Journal Article
Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M
Published in Organic process research & development (17.01.2014)
Published in Organic process research & development (17.01.2014)
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Journal Article
Practical and Cost-Effective Manufacturing Route for the Synthesis of a β‑Lactamase Inhibitor
Miller, Steven P, Zhong, Yong-Li, Liu, Zhijian, Simeone, Michael, Yasuda, Nobuyoshi, Limanto, John, Chen, Zheng, Lynch, Joseph, Capodanno, Vincent
Published in Organic letters (03.01.2014)
Published in Organic letters (03.01.2014)
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Journal Article
Dynamic Kinetic Resolution: Asymmetric Transfer Hydrogenation of α-Alkyl-Substituted β-Ketoamides
Limanto, John, Krska, Shane W, Dorner, Benjamin T, Vazquez, Enrique, Yoshikawa, Naoki, Tan, Lushi
Published in Organic letters (05.02.2010)
Published in Organic letters (05.02.2010)
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Journal Article
Kilogram-Scale Synthesis of 2′‑C‑Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation
Chung, John Y. L, Kassim, Amude M, Simmons, Bryon, Davis, Tyler A, Song, Zhiguo J, Limanto, John, Dalby, Stephen M, He, Cyndi Q, Calabria, Ralph, Wright, Timothy J, Campeau, Louis-Charles
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Promotion of a Ti-Mediated Mannich Reaction by a Proton Source
Limanto, John, Yoshikawa, Naoki, Reamer, Robert A, Tan, Lushi, Brunskill, Andrew, Reibarkh, Mikhail
Published in Journal of organic chemistry (15.01.2016)
Published in Journal of organic chemistry (15.01.2016)
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Journal Article
Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods
Klapars, Artis, Chung, John Y. L, Limanto, John, Calabria, Ralph, Campeau, Louis-Charles, Campos, Kevin R, Chen, Wenyong, Dalby, Stephen M, Davis, Tyler A, DiRocco, Daniel A, Hyde, Alan M, Kassim, Amude M, Larsen, Mona Utne, Liu, Guiquan, Maligres, Peter E, Moment, Aaron, Peng, Feng, Ruck, Rebecca T, Shevlin, Michael, Simmons, Bryon L, Song, Zhiguo Jake, Tan, Lushi, Wright, Timothy J, Zultanski, Susan L
Published in Chemical science (Cambridge) (07.07.2021)
Published in Chemical science (Cambridge) (07.07.2021)
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Journal Article
A Highly Efficient Asymmetric Synthesis of Vernakalant
Limanto, John, Ashley, Eric R, Yin, Jingjun, Beutner, Gregory L, Grau, Brendan T, Kassim, Amude M, Kim, Mary M, Klapars, Artis, Liu, Zhijian, Strotman, Hallena R, Truppo, Matthew D
Published in Organic letters (16.05.2014)
Published in Organic letters (16.05.2014)
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Journal Article
Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine
Maligres, Peter E., Peng, Feng, Calabria, Ralph, Campeau, Louis-Charles, Chen, Wenyong, Dormer, Peter G., Green, Meredith, He, Cyndi Qixin, Hyde, Alan M., Klapars, Artis, Larsen, Mona Utne, Limanto, John, Liu, Guiquan, Liu, Yizhou, Moment, Aaron, Nowak, Timothy, Ruck, Rebecca T., Shevlin, Michael, Song, Zhiguo Jake, Tan, Lushi, Tong, Weidong, Waldman, Jacob H., Ye, Honglin, Zhao, Ralph, Zhou, George, Zompa, Michael A., Zultanski, Susan L.
Published in Organic process research & development (16.09.2022)
Published in Organic process research & development (16.09.2022)
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Journal Article
Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction
Hyde, Alan M, Liu, Zhijian, Kosjek, Birgit, Tan, Lushi, Klapars, Artis, Ashley, Eric R, Zhong, Yong-Li, Alvizo, Oscar, Agard, Nicholas J, Liu, Guiquan, Gu, Xiuyan, Yasuda, Nobuyoshi, Limanto, John, Huffman, Mark A, Tschaen, David M
Published in Organic letters (18.11.2016)
Published in Organic letters (18.11.2016)
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Journal Article
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor
Zhong, Yong-Li, Cleator, Ed, Liu, Zhijian, Yin, Jianguo, Morris, William J, Alam, Mahbub, Bishop, Brian, Dumas, Aaron M, Edwards, John, Goodyear, Adrian, Mullens, Peter, Song, Zhiguo Jake, Shevlin, Michael, Thaisrivongs, David A, Li, Hongming, Sherer, Edward C, Cohen, Ryan D, Yin, Jingjun, Tan, Lushi, Yasuda, Nobuyoshi, Limanto, John, Davies, Antony, Campos, Kevin R
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
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