Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Savage, Scott, McClory, Andrew, Zhang, Haiming, Cravillion, Theresa, Lim, Ngiap-Kie, Masui, Colin, Robinson, Sarah J, Han, Chong, Ochs, Christoph, Rege, Pankaj D, Gosselin, Francis
Published in Journal of organic chemistry (05.10.2018)
Published in Journal of organic chemistry (05.10.2018)
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Journal Article
A fit for purpose synthesis of Bruton’s tyrosine kinase inhibitor GDC-0852
Lim, Ngiap-Kie, Zhang, Haiming, Sowell, C. Gregory, Gosselin, Francis
Published in Tetrahedron letters (29.10.2020)
Published in Tetrahedron letters (29.10.2020)
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Journal Article
Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036
Xu, Jie, Grosslight, Samantha, Mack, Kyle A., Nguyen, Sierra C., Clagg, Kyle, Lim, Ngiap-Kie, Timmerman, Jacob C., Shen, Jeff, White, Nicholas A., Sirois, Lauren E., Han, Chong, Zhang, Haiming, Sigman, Matthew S., Gosselin, Francis
Published in Journal of the American Chemical Society (16.11.2022)
Published in Journal of the American Chemical Society (16.11.2022)
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Journal Article
Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides
van Dijk, Lucy, Haas, Brittany C., Lim, Ngiap-Kie, Clagg, Kyle, Dotson, Jordan J., Treacy, Sean M., Piechowicz, Katarzyna A., Roytman, Vladislav A., Zhang, Haiming, Toste, F. Dean, Miller, Scott J., Gosselin, Francis, Sigman, Matthew S.
Published in Journal of the American Chemical Society (27.09.2023)
Published in Journal of the American Chemical Society (27.09.2023)
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Journal Article
Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki–Miyaura Coupling
Li, Beryl X, Le, Diane N, Mack, Kyle A, McClory, Andrew, Lim, Ngiap-Kie, Cravillion, Theresa, Savage, Scott, Han, Chong, Collum, David B, Zhang, Haiming, Gosselin, Francis
Published in Journal of the American Chemical Society (09.08.2017)
Published in Journal of the American Chemical Society (09.08.2017)
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Journal Article
Macrolactamization Approaches to Arylomycin Antibiotics Core
Lim, Ngiap-Kie, Linghu, Xin, Wong, Nicholas, Zhang, Haiming, Sowell, C. Gregory, Gosselin, Francis
Published in Organic letters (04.01.2019)
Published in Organic letters (04.01.2019)
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Journal Article
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036
Xu, Jie, Lim, Ngiap-Kie, Timmerman, Jacob C., Shen, Jeff, Clagg, Kyle, Orcel, Ugo, Bigler, Raphael, Trachsel, Etienne, Meier, Roland, White, Nicholas A., Burkhard, Johannes A., Sirois, Lauren E., Tian, Qingping, Angelaud, Remy, Bachmann, Stephan, Zhang, Haiming, Gosselin, Francis
Published in Organic letters (19.05.2023)
Published in Organic letters (19.05.2023)
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Journal Article
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation
Haas, Brittany C., Lim, Ngiap-Kie, Jermaks, Janis, Gaster, Eden, Guo, Melody C., Malig, Thomas C., Werth, Jacob, Zhang, Haiming, Toste, F. Dean, Gosselin, Francis, Miller, Scott J., Sigman, Matthew S.
Published in Journal of the American Chemical Society (27.03.2024)
Published in Journal of the American Chemical Society (27.03.2024)
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Journal Article
First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet–Spengler Reaction and a C–N Coupling Reaction
Xu, Jie, Clagg, Kyle, Lim, Ngiap-Kie, Wuitschik, Georg, Chung, Cheol K, Zhang, Haiming, Gosselin, Francis
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach
Lim, Ngiap-Kie, Cravillion, Theresa, Savage, Scott, McClory, Andrew, Han, Chong, Zhang, Haiming, DiPasquale, Antonio, Gosselin, Francis
Published in Organic letters (16.02.2018)
Published in Organic letters (16.02.2018)
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Journal Article
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation
Xu, Jie, Chung, Cheol K., McClory, Andrew, Mack, Kyle A., Dalziel, Michael E., Fettes, Alec, Clagg, Kyle, Lim, Ngiap-Kie, Wuitschik, Georg, Jenny, Christian, Finet, Laure, Kammerer, Michael, Zhang, Haiming, Angelaud, Rémy, Gosselin, Francis
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes
Zhao, Matthew M, Zhang, Haiming, Iimura, Shinya, Bednarz, Mark S, Song, Qiu-Ling, Lim, Ngiap-Kie, Yan, Jie, Wu, Wenxue, Dai, Kuangchu, Gu, Xiaodong, Wang, Youchu
Published in Organic process research & development (20.11.2020)
Published in Organic process research & development (20.11.2020)
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Journal Article
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Bronner, Sarah M., Merrick, Karl A., Murray, Jeremy, Salphati, Laurent, Moffat, John G., Pang, Jodie, Sneeringer, Christopher J., Dompe, Nicholas, Cyr, Patrick, Purkey, Hans, Boenig, Gladys de Leon, Li, Jun, Kolesnikov, Aleksandr, Larouche-Gauthier, Robin, Lai, Kwong Wah, Shen, Xiaoli, Aubert-Nicol, Samuel, Chen, Yi-Chen, Cheong, Jonathan, Crawford, James J., Hafner, Marc, Haghshenas, Pouyan, Jakalian, Araz, Leclerc, Jean-Philippe, Lim, Ngiap-Kie, O'Brien, Tom, Plise, Emile G., Shalan, Hadil, Sturino, Claudio, Wai, John, Xiao, Yang, Yin, Jianping, Zhao, Liang, Gould, Stephen, Olivero, Alan, Heffron, Timothy P.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Journal Article
Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338
Wong, Nicholas, Petronijević, Filip, Hong, Allen Y, Linghu, Xin, Kelly, Sean M, Hou, Haiyun, Cravillion, Theresa, Lim, Ngiap-Kie, Robinson, Sarah J, Han, Chong, Molinaro, Carmela, Sowell, C. Gregory, Gosselin, Francis
Published in Organic letters (15.11.2019)
Published in Organic letters (15.11.2019)
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Journal Article
Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome
Zhao, Matthew M, Zhang, Haiming, Iimura, Shinya, Bednarz, Mark S, Kanamarlapudi, Ramanaiah C, Yan, Jie, Lim, Ngiap-Kie, Wu, Wenxue
Published in Organic process research & development (21.02.2020)
Published in Organic process research & development (21.02.2020)
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Journal Article
Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All‑Carbon Olefins via a Syn-Elimination Approach
Lim, Ngiap-Kie, Weiss, Patrick, Li, Beryl X., McCulley, Christina H., Hare, Stephanie R., Bensema, Bronwyn L., Palazzo, Teresa A., Tantillo, Dean J., Zhang, Haiming, Gosselin, Francis
Published in Organic letters (17.11.2017)
Published in Organic letters (17.11.2017)
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Journal Article
Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp(3)-sp(2) Suzuki Coupling of a Benzyl Carbonate
Sirois, Lauren E., Zhao, Matthew M., Lim, Ngiap-Kie, Bednarz, Mark S., Harrison, Bryce A., Wuo, Wenxue
Published in Organic process research & development (18.01.2019)
Published in Organic process research & development (18.01.2019)
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Journal Article
One-Pot Synthesis of 4‑Substituted 3‑Amino-2-cyanothiophenes Involving O‑Ethyl Thioformate
Zhang, Haiming, Bednarz, Mark S., Lim, Ngiap-Kie, Hernandez, Gonzalo, Wu, Wenxue
Published in Organic letters (02.05.2014)
Published in Organic letters (02.05.2014)
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