Reproducing human and cross-species drug toxicities using a Liver-Chip
Jang, Kyung-Jin, Otieno, Monicah A, Ronxhi, Janey, Lim, Heng-Keang, Ewart, Lorna, Kodella, Konstantia R, Petropolis, Debora B, Kulkarni, Gauri, Rubins, Jonathan E, Conegliano, David, Nawroth, Janna, Simic, Damir, Lam, Wing, Singer, Monica, Barale, Erio, Singh, Bhanu, Sonee, Manisha, Streeter, Anthony J, Manthey, Carl, Jones, Barry, Srivastava, Abhishek, Andersson, Linda C, Williams, Dominic, Park, Hyoungshin, Barrile, Riccardo, Sliz, Josiah, Herland, Anna, Haney, Suzzette, Karalis, Katia, Ingber, Donald E, Hamilton, Geraldine A
Published in Science translational medicine (06.11.2019)
Published in Science translational medicine (06.11.2019)
Get more information
Journal Article
Bifunctionalized isotopologs as calibrants for standard‐free quantitation of drug metabolites in plasma by liquid chromatography coupled with radiometry and mass spectrometry
Gong, Yong, Chen, Jie, Lim, Heng‐Keang, Weng, Naidong, Salter, Rhys
Published in Biomedical chromatography (01.01.2022)
Published in Biomedical chromatography (01.01.2022)
Get full text
Journal Article
The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
GRIMM, Scott W, EINOLF, Heidi J, TONN, George R, VAN HORN, Robert, WANG, Regina W, WONG, Y. Nancy, YANG, Tian J, OBACH, R. Scott, HALL, Steven D, KAN HE, LIM, Heng-Keang, LING, Kah-Hiing John, CHUANG LU, NOMEIR, Amin A, SEIBERT, Eleanore, SKORDOS, Konstantine W
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
Get full text
Journal Article
Preparation of PEGylated Iodine‐Loaded Nanoparticles via Polymer‐Directed Self‐Assembly
Tang, Christina, York, Adam W., Mikitsh, John L., Wright, Alexander C., Chacko, Ann‐Marie, Elias, Drew R., Xu, Yaodong, Lim, Heng‐Keang, Prud'homme, Robert K.
Published in Macromolecular chemistry and physics (01.06.2018)
Published in Macromolecular chemistry and physics (01.06.2018)
Get full text
Journal Article
Metabolite identification by data-dependent accurate mass spectrometric analysis at resolving power of 60 000 in external calibration mode using an LTQ/Orbitrap
Lim, Heng-Keang, Chen, Jie, Sensenhauser, Carlo, Cook, Kevin, Subrahmanyam, Vangala
Published in Rapid communications in mass spectrometry (01.01.2007)
Published in Rapid communications in mass spectrometry (01.01.2007)
Get full text
Journal Article
Standard-Free Bioanalytical Approach for Absolute Quantitation of Drug Metabolites Utilizing Biosynthesis of Reciprocal Radio and Stable Isotopologues and Its Application
Gong, Yong, Chen, Jie, Shi, Yifan, Lim, Heng-Keang, Weng, Naidong, Salter, Rhys
Published in Analytical chemistry (Washington) (15.08.2017)
Published in Analytical chemistry (Washington) (15.08.2017)
Get full text
Journal Article
A generic method to detect electrophilic intermediates using isotopic pattern triggered data-dependent high-resolution accurate mass spectrometry
Lim, Heng-Keang, Chen, Jie, Cook, Kevin, Sensenhauser, Carlo, Silva, Jose, Evans, David C.
Published in Rapid communications in mass spectrometry (30.04.2008)
Published in Rapid communications in mass spectrometry (30.04.2008)
Get full text
Journal Article
Contribution of metabolites to P450 inhibition-based drug-drug interactions: scholarship from the drug metabolism leadership group of the innovation and quality consortium metabolite group
Yu, Hongbin, Balani, Suresh K, Chen, Weichao, Cui, Donghui, He, Ling, Humphreys, W Griffith, Mao, Jialin, Lai, W George, Lee, Anthony J, Lim, Heng-Keang, MacLauchlin, Christopher, Prakash, Chandra, Surapaneni, Sekhar, Tse, Susanna, Upthagrove, Alana, Walsky, Robert L, Wen, Bo, Zeng, Zhaopie
Published in Drug metabolism and disposition (01.04.2015)
Published in Drug metabolism and disposition (01.04.2015)
Get full text
Journal Article
AUTOMATED SCREENING WITH CONFIRMATION OF MECHANISM-BASED INACTIVATION OF CYP3A4, CYP2C9, CYP2C19, CYP2D6, AND CYP1A2 IN POOLED HUMAN LIVER MICROSOMES
Heng-Keang Lim, Nicholas Duczak, Jr, Linda Brougham, Michael Elliot, Krupa Patel, Kelvin Chan
Published in Drug metabolism and disposition (01.08.2005)
Published in Drug metabolism and disposition (01.08.2005)
Get full text
Journal Article
Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury
Otieno, Monicah A, Snoeys, Jan, Lam, Wing, Ghosh, Avi, Player, Mark R, Pocai, Alessandro, Salter, Rhys, Simic, Damir, Skaggs, Hollie, Singh, Bhanu, Lim, Heng-Keang
Published in Toxicological sciences (01.06.2018)
Published in Toxicological sciences (01.06.2018)
Get full text
Journal Article
Pharmacokinetics of sirolimus (rapamycin) in subjects with mild to moderate hepatic impairment
Zimmerman, James J, Lasseter, Kenneth C, Lim, Heng-Keang, Harper, Dawn, Dilzer, Stacey C, Parker, Vernon, Matschke, Kyle
Published in Journal of clinical pharmacology (01.12.2005)
Published in Journal of clinical pharmacology (01.12.2005)
Get more information
Journal Article
Metabolism and disposition of JNJ-10450232 (NTM-006) in rats, dogs, monkeys and humans
Lim, Heng-Keang, Chen, Jie, Lam, Wing, Gong, Yong, Leclercq, Laurent, Silva, Jose, Salter, Rhys, Berwaerts, Joris, Gelotte, Cathy K., Vakil, Amy M., Eichenbaum, Gary E., Kuffner, Edwin K., Flores, Christopher M.
Published in Regulatory toxicology and pharmacology (16.03.2023)
Published in Regulatory toxicology and pharmacology (16.03.2023)
Get full text
Journal Article
In vitro and physiologically‐based pharmacokinetic based assessment of drug–drug interaction potential of canagliflozin
Mamidi, Rao N. V. S., Dallas, Shannon, Sensenhauser, Carlo, Lim, Heng Keang, Scheers, Ellen, Verboven, Peter, Cuyckens, Filip, Leclercq, Laurent, Evans, David C., Kelley, Michael F., Johnson, Mark D., Snoeys, Jan
Published in British journal of clinical pharmacology (01.05.2017)
Published in British journal of clinical pharmacology (01.05.2017)
Get full text
Journal Article
LC–ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume
Xu, Yaodong, Yuan, Yang, Smith, Lisa, Edom, Rick, Weng, Naidong, Mamidi, Rao, Silva, Jose, Evans, David C., Lim, Heng-Keang
Published in Journal of pharmaceutical and biomedical analysis (01.11.2013)
Published in Journal of pharmaceutical and biomedical analysis (01.11.2013)
Get full text
Journal Article
Production of GABA by cultured hippocampal glial cells
Jow, Flora, Chiu, Doreen, Lim, Heng-Keang, Novak, Tom, Lin, Stephen
Published in Neurochemistry international (01.07.2004)
Published in Neurochemistry international (01.07.2004)
Get full text
Journal Article
Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer
Zhang, Zhuming, Connolly, Peter J, Trabalón Escolar, Luis, Rocaboy, Christian, Pande, Vineet, Meerpoel, Lieven, Lim, Heng-Keang, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy L, Bischoff, James R, Bignan, Gilles
Published in ACS medicinal chemistry letters (12.08.2021)
Published in ACS medicinal chemistry letters (12.08.2021)
Get full text
Journal Article
The effect of a high-fat meal on the oral bioavailability of the immunosuppressant sirolimus (rapamycin)
Zimmerman, J J, Ferron, G M, Lim, H K, Parker, V
Published in Journal of clinical pharmacology (01.11.1999)
Published in Journal of clinical pharmacology (01.11.1999)
Get more information
Journal Article
Bio-generation of stable isotope labeled internal standards for absolute and relative quantitation of drug metabolites in plasma samples by LC–MS/MS
Li, Pei, Gong, Yong, Lim, Heng-Keang, Jian, Wenying, Edom, Richard W., Salter, Rhys, Silva, Jose, Weng, Naidong
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2013)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.05.2013)
Get full text
Journal Article
Design and Characterization of Optimized Adenosine A 2A /A 1 Receptor Antagonists for the Treatment of Parkinson's Disease
Shook, Brian C., Rassnick, Stefanie, Wallace, Nathaniel, Crooke, Jeffrey, Ault, Mark, Chakravarty, Devraj, Barbay, J. Kent, Wang, Aihua, Powell, Mark T., Leonard, Kristi, Alford, Vernon, Scannevin, Robert H., Carroll, Karen, Lampron, Lisa, Westover, Lori, Lim, Heng-Keang, Russell, Ronald, Branum, Shawn, Wells, Kenneth M., Damon, Sandra, Youells, Scott, Li, Xun, Beauchamp, Derek A., Rhodes, Kenneth, Jackson, Paul F.
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article