Preclinical Characterization of ARX517, a Site-specific Stable PSMA-Targeted Antibody Drug Conjugate for Treatment of Metastatic Castration-Resistant Prostate Cancer
Skidmore, Lillian K, Mills, David, Kim, Ji Young, Knudsen, Nick A, Nelson, Jay D, Pal, Manoj, Wang, Jianing, Gc, Kedar, Gray, Michael J, Barkho, Wisam, Nagaraja Shastri, Prathap, Ramprasad, Mysore P, Tian, Feng, O'Connor, Daniel, Buechler, Ying J, Zhang, Shawn Shao-Hui
Published in Molecular cancer therapeutics (22.08.2024)
Published in Molecular cancer therapeutics (22.08.2024)
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Journal Article
Analytical comparability to evaluate impact of manufacturing changes of ARX788, an Anti-HER2 ADC in late-stage clinical development
Yu, Wayne, Ramprasad, Mysore P, Pal, Manoj, Chen, Chris, Paruchuri, Shashi, Skidmore, Lillian, Knudsen, Nick, Allen, Molly, Buechler, Ying
Published in PloS one (10.07.2023)
Published in PloS one (10.07.2023)
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Journal Article
FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
MU, James, PINKSTAFF, Jason, WU, Margaret, NORMAN, Thea C, RODRIGUEZ, Carlos G, KIMMEL, Bruce, METZGER, Joseph M, MANIBUSAN, Anthony, LEE, Darin, ZALLER, Dennis M, ZHANG, Bei B, DIMARCHI, Richard D, ZHIHUA LI, BERGER, Joel P, AXELROD, Douglas W, SKIDMORE, Lillian, NINA LI, MYLER, Heather, DALLAS-YANG, Qing, PUTNAM, Anna-Maria, JUN YAO, BUSSELL, Stuart
Published in Diabetes (New York, N.Y.) (01.02.2012)
Published in Diabetes (New York, N.Y.) (01.02.2012)
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Journal Article
Prophylactic treatment with PEGylated bovine IFNλ3 effectively bridges the gap in vaccine-induced immunity against FMD in cattle
Attreed, Sarah E, Silva, Christina, Rodriguez-Calzada, Monica, Mogulothu, Aishwarya, Abbott, Sophia, Azzinaro, Paul, Canning, Peter, Skidmore, Lillian, Nelson, Jay, Knudsen, Nick, Medina, Gisselle N, de Los Santos, Teresa, Díaz-San Segundo, Fayna
Published in Frontiers in microbiology (04.04.2024)
Published in Frontiers in microbiology (04.04.2024)
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Journal Article
ARX788, a Site-specific Anti-HER2 Antibody–Drug Conjugate, Demonstrates Potent and Selective Activity in HER2-low and T-DM1–resistant Breast and Gastric Cancers
Skidmore, Lillian, Sakamuri, Sukumar, Knudsen, Nick A., Hewet, Amha Gebre, Milutinovic, Snezana, Barkho, Wisam, Biroc, Sandra Lyn, Kirtley, Jessica, Marsden, Robin, Storey, Kristine, Lopez, Ianina, Yu, Wayne, Fang, Shiao-Yan, Yao, Sulan, Gu, Yi, Tian, Feng
Published in Molecular cancer therapeutics (01.09.2020)
Published in Molecular cancer therapeutics (01.09.2020)
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Journal Article
Nonclinical Development of Next-generation Site-specific HER2-targeting Antibody-drug Conjugate (ARX788) for Breast Cancer Treatment
Nagaraja Shastri, Prathap, Zhu, Jingjing, Skidmore, Lillian, Liang, Xuejun, Ji, Yanping, Gu, Yi, Tian, Feng, Yao, Sulan, Xia, Gang
Published in Molecular cancer therapeutics (01.09.2020)
Published in Molecular cancer therapeutics (01.09.2020)
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Journal Article
Abstract 639: Site specific conjugation of ARX-788, an antibody drug conjugate (ADC) targeting HER2, generates a potent and stable targeted therapeutic for multiple cancers
Humphreys, Robin C., Kirtely, Jessica, Hewit, Amha, Biroc, Sandra, Knudsen, Nick, Skidmore, Lillian, Wahl, Alan
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 3997: Preclinical characterization of ARX517, a next-generation anti-PSMA antibody drug conjugate for the treatment of metastatic castration-resistant prostate cancer
Skidmore, Lillian, Mills, David, Kim, Ji Young, Shastri, Prathap, Knudsen, Nick A., Steen, Jeff, Nelson, Jay, Buechler, Ying, Tian, Feng, Zhang, Shawn
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 6352: Preclinical discovery of ARX622: A site-specific, TLR7 agonist, HER2-targeted immune-stimulatory antibody drug conjugate for treatment of multiple solid tumor types
Mills, David, Kim, Ji Young, Wood, Erica, Tatsukawa, Keith, Knudsen, Nick, Nelson, Jay, Skidmore, Lillian, GC, Kedar, Tran, Hon, Pal, Manoj, Hashemi, Hamidreza, Buechler, Ying, Zhang, Shawn, O'Connor, Dan
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract 6318: Preclinical characterization of ARX305, a next-generation anti-CD70 antibody drug conjugate for the treatment of CD70-expressing cancers
Skidmore, Lillian, Zhu, Jingjing, Mills, David, Jin, Ting, Li, Suqin, Tatsukawa, Keith, Knudsen, Nick A., Gong, Liying, Nelson, Jay, Cox, Kari, Hewet, Amha G., Wang, Jianing, Buss, Tim, Tian, Feng, Xia, Gang, Zhang, Shawn
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract LB-222: Optimization and preclinical characterization of highly potent and stable anti-CD70 ADCs for the potential treatment of CD70 positive cancers
Skidmore, Lillian, Cox, Kari, Kirtley, Jessica, Le, Tiep, Firdos, Juhi, Manibusan, Anthony, Fang, Shiao-Yan, Beck, Andy, Bhowmik, Shiva, Knudsen, Nick, Wang, Jianing, Sun, Ying, Ayala, Armando, Powell, Alyssa, Wahl, Alan, Tian, Feng, Humphreys, Robin
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Abstract 5616: Tumor-targeted immune activation via a site-specific TLR7-agonist antibody-drug conjugate
Kang, Mingchao, Moon, Sung-Ju, Kim, Ji Young, Beck, Andy, Allen, Molly, Nelson, Jay, Tatsukawa, Keith, Tran, Hon, Pal, Manoj, Gray, Michael, Knudsen, Nick, Skidmore, Lillian, Mills, David, Lu, Yingchun, Buechler, Ying, Sakamuri, Sukumar, Zhang, Shawn, Tian, Feng
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 668: Folate conjugated site-specifically to anti-human-CD3-Fab is efficacious in mouse models of ovarian cancer
Biroc, Sandra L., Gymnopoulos, Marco, Srinagesh, Shailaja, Hayes, Brad, Knudsen, Nick, Manibusan, Anthony, Pinkstaff, Jason, Buss, Tim, Cox, Kari, Marsden, Robin, Skidmore, Lillian, Xia, Jinming, Sun, Ying, Zou, Ning, Javahishvili, Tsotne
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES
MIAO ZHENWEI, ROBIN MARSDEN, VADIM KRAYNOV, SANDRA BIROC, LILLIAN SKIDMORE, DELIA LANINA LOPEZ DE VALENTA, KYLE C ATKINSON, SUN YING, TIMOTHY BUSS, AGNIESZKA SZYDLIK, MELISSA NEAL, JASON PINKSTAFF
Year of Publication 17.09.2020
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Year of Publication 17.09.2020
Patent
COMPOSITIONS CONTAINING NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES, METHODS EMPLOYING THE SAME, AND USES THEREOF
MIAO ZHENWEI, ROBIN MARSDEN, VADIM KRAYNOV, SANDRA BIROC, LILLIAN SKIDMORE, DELIA LANINA LOPEZ DE VALENTA, KYLE C ATKINSON, SUN YING, TIMOTHY BUSS, AGNIESZKA SZYDLIK, MELISSA NEAL, JASON PINKSTAFF
Year of Publication 12.07.2018
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Year of Publication 12.07.2018
Patent
ANTI-CD70 ANTIBODY-DRUG CONJUGATES
KNUDSEN, Nickolas, SKIDMORE, Lillian, KIM, Ji Young, LU, Yingchun, RAMPRASAD, Mysore
Year of Publication 25.07.2024
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Year of Publication 25.07.2024
Patent