Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker
Kugeratski, Fernanda G, Hodge, Kelly, Lilla, Sergio, McAndrews, Kathleen M, Zhou, Xunian, Hwang, Rosa F, Zanivan, Sara, Kalluri, Raghu
Published in Nature cell biology (01.06.2021)
Published in Nature cell biology (01.06.2021)
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Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
van der Reest, Jiska, Lilla, Sergio, Zheng, Liang, Zanivan, Sara, Gottlieb, Eyal
Published in Nature communications (20.04.2018)
Published in Nature communications (20.04.2018)
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2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
Blomme, Arnaud, Ford, Catriona A, Mui, Ernest, Patel, Rachana, Ntala, Chara, Jamieson, Lauren E, Planque, Mélanie, McGregor, Grace H, Peixoto, Paul, Hervouet, Eric, Nixon, Colin, Salji, Mark, Gaughan, Luke, Markert, Elke, Repiscak, Peter, Sumpton, David, Blanco, Giovanny Rodriguez, Lilla, Sergio, Kamphorst, Jurre J, Graham, Duncan, Faulds, Karen, MacKay, Gillian M, Fendt, Sarah-Maria, Zanivan, Sara, Leung, Hing Y
Published in Nature communications (19.05.2020)
Published in Nature communications (19.05.2020)
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Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion
Marco, Sergi, Neilson, Matthew, Moore, Madeleine, Perez-Garcia, Arantxa, Hall, Holly, Mitchell, Louise, Lilla, Sergio, Blanco, Giovani R, Hedley, Ann, Zanivan, Sara, Norman, Jim C
Published in Nature communications (24.11.2021)
Published in Nature communications (24.11.2021)
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Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
Kugeratski, Fernanda G, Atkinson, Samuel J, Neilson, Lisa J, Lilla, Sergio, Knight, John R P, Serneels, Jens, Juin, Amelie, Ismail, Shehab, Bryant, David M, Markert, Elke K, Machesky, Laura M, Mazzone, Massimiliano, Sansom, Owen J, Zanivan, Sara
Published in Science signaling (05.02.2019)
Published in Science signaling (05.02.2019)
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An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism
Nacke, Marisa, Sandilands, Emma, Nikolatou, Konstantina, Román-Fernández, Álvaro, Mason, Susan, Patel, Rachana, Lilla, Sergio, Yelland, Tamas, Galbraith, Laura C A, Freckmann, Eva C, McGarry, Lynn, Morton, Jennifer P, Shanks, Emma, Leung, Hing Y, Markert, Elke, Ismail, Shehab, Zanivan, Sara, Blyth, Karen, Bryant, David M
Published in Nature communications (12.03.2021)
Published in Nature communications (12.03.2021)
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E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis
Ahmed, Syed Feroj, Buetow, Lori, Gabrielsen, Mads, Lilla, Sergio, Sibbet, Gary J, Sumpton, David, Zanivan, Sara, Hedley, Ann, Clark, William, Huang, Danny T
Published in Oncogene (25.03.2021)
Published in Oncogene (25.03.2021)
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Journal Article
BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
Loveridge, Carolyn J, Slater, Sarah, Campbell, Kirsteen J, Nam, Noor A, Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N, Goodyear, Carl S, Blyth, Karen, Leung, Hing Y
Published in Oncogene (01.02.2020)
Published in Oncogene (01.02.2020)
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Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
Hernandez-Fernaud, Juan R, Ruengeler, Elena, Casazza, Andrea, Neilson, Lisa J, Pulleine, Ellie, Santi, Alice, Ismail, Shehab, Lilla, Sergio, Dhayade, Sandeep, MacPherson, Iain R, McNeish, Iain, Ennis, Darren, Ali, Hala, Kugeratski, Fernanda G, Al Khamici, Heba, van den Biggelaar, Maartje, van den Berghe, Peter V E, Cloix, Catherine, McDonald, Laura, Millan, David, Hoyle, Aoisha, Kuchnio, Anna, Carmeliet, Peter, Valenzuela, Stella M, Blyth, Karen, Yin, Huabing, Mazzone, Massimiliano, Norman, Jim C, Zanivan, Sara
Published in Nature communications (15.02.2017)
Published in Nature communications (15.02.2017)
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Formate induces a metabolic switch in nucleotide and energy metabolism
Oizel, Kristell, Tait-Mulder, Jacqueline, Fernandez-de-Cossio-Diaz, Jorge, Pietzke, Matthias, Brunton, Holly, Lilla, Sergio, Dhayade, Sandeep, Athineos, Dimitri, Blanco, Giovanny Rodriguez, Sumpton, David, Mackay, Gillian M, Blyth, Karen, Zanivan, Sara R, Meiser, Johannes, Vazquez, Alexei
Published in Cell death & disease (04.05.2020)
Published in Cell death & disease (04.05.2020)
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Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime
Singh, Shashi Prakash, Thomason, Peter A, Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L, Machesky, Laura M, Rottner, Klemens, Insall, Robert H
Published in PLoS biology (03.08.2020)
Published in PLoS biology (03.08.2020)
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SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer
Martinez, Rafael S, Salji, Mark J, Rushworth, Linda, Ntala, Chara, Rodriguez Blanco, Giovanny, Hedley, Ann, Clark, William, Peixoto, Paul, Hervouet, Eric, Renaude, Elodie, Kung, Sonia H Y, Galbraith, Laura C A, Nixon, Colin, Lilla, Sergio, MacKay, Gillian M, Fazli, Ladan, Gaughan, Luke, Sumpton, David, Gleave, Martin E, Zanivan, Sara, Blomme, Arnaud, Leung, Hing Y
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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MICAL1 activation by PAK1 mediates actin filament disassembly
McGarry, David J., Castino, Giovanni, Lilla, Sergio, Carnet, Alexandre, Kelly, Loughlin, Micovic, Katarina, Zanivan, Sara, Olson, Michael F.
Published in Cell reports (Cambridge) (04.10.2022)
Published in Cell reports (Cambridge) (04.10.2022)
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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress
Port, Jennifer, Muthalagu, Nathiya, Raja, Meera, Ceteci, Fatih, Monteverde, Tiziana, Kruspig, Björn, Hedley, Ann, Kalna, Gabriela, Lilla, Sergio, Neilson, Lisa, Brucoli, Martina, Gyuraszova, Katarina, Tait-Mulder, Jacqueline, Mezna, Mokdad, Svambaryte, Silvija, Bryson, Amy, Sumpton, David, McVie, Allan, Nixon, Colin, Drysdale, Martin, Esumi, Hiroyasu, Murray, Graeme I, Sansom, Owen J, Zanivan, Sara R, Murphy, Daniel J
Published in Cancer discovery (01.05.2018)
Published in Cancer discovery (01.05.2018)
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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
Kay, Emily J, Paterson, Karla, Riera-Domingo, Carla, Sumpton, David, Däbritz, J Henry M, Tardito, Saverio, Boldrini, Claudia, Hernandez-Fernaud, Juan R, Athineos, Dimitris, Dhayade, Sandeep, Stepanova, Ekaterina, Gjerga, Enio, Neilson, Lisa J, Lilla, Sergio, Hedley, Ann, Koulouras, Grigorios, McGregor, Grace, Jamieson, Craig, Johnson, Radia Marie, Park, Morag, Kirschner, Kristina, Miller, Crispin, Kamphorst, Jurre J, Loayza-Puch, Fabricio, Saez-Rodriguez, Julio, Mazzone, Massimiliano, Blyth, Karen, Zagnoni, Michele, Zanivan, Sara
Published in Nature metabolism (01.06.2022)
Published in Nature metabolism (01.06.2022)
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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Unbekandt, Mathieu, Belshaw, Simone, Bower, Justin, Clarke, Maeve, Cordes, Jacqueline, Crighton, Diane, Croft, Daniel R, Drysdale, Martin J, Garnett, Mathew J, Gill, Kathryn, Gray, Christopher, Greenhalgh, David A, Hall, James A M, Konczal, Jennifer, Lilla, Sergio, McArthur, Duncan, McConnell, Patricia, McDonald, Laura, McGarry, Lynn, McKinnon, Heather, McMenemy, Carol, Mezna, Mokdad, Morrice, Nicolas A, Munro, June, Naylor, Gregory, Rath, Nicola, Schüttelkopf, Alexander W, Sime, Mairi, Olson, Michael F
Published in Cancer research (Chicago, Ill.) (15.04.2018)
Published in Cancer research (Chicago, Ill.) (15.04.2018)
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Correction: BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration
Loveridge, Carolyn J, Slater, Sarah, Campbell, Kirsteen J, Nam, Noor A, Knight, John, Ahmad, Imran, Hedley, Ann, Lilla, Sergio, Repiscak, Peter, Patel, Rachana, Salji, Mark, Fleming, Janis, Mitchell, Louise, Nixon, Colin, Strathdee, Douglas, Neilson, Matthew, Ntala, Chara, Bryson, Sheila, Zanivan, Sara, Edwards, Joanne, Robson, Craig N, Goodyear, Carl S, Blyth, Karen, Leung, Hing Y
Published in Oncogene (01.03.2020)
Published in Oncogene (01.03.2020)
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Mechanistic insights into p53‐regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells
Marx, Christian, Sonnemann, Jürgen, Beyer, Mandy, Maddocks, Oliver D. K., Lilla, Sergio, Hauzenberger, Irene, Piée‐Staffa, Andrea, Siniuk, Kanstantsin, Nunna, Suneetha, Marx‐Blümel, Lisa, Westermann, Martin, Wagner, Tobias, Meyer, Felix B., Thierbach, René, Mullins, Christina S., Kdimati, Said, Linnebacher, Michael, Neri, Francesco, Heinzel, Thorsten, Wang, Zhao‐Qi, Krämer, Oliver H.
Published in Molecular oncology (01.12.2021)
Published in Molecular oncology (01.12.2021)
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MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
Närvä, Elisa, Taskinen, Maria E., Lilla, Sergio, Isomursu, Aleksi, Pietilä, Mika, Weltner, Jere, Isola, Jorma, Sihto, Harri, Joensuu, Heikki, Zanivan, Sara, Norman, Jim, Ivaska, Johanna
Published in iScience (17.06.2022)
Published in iScience (17.06.2022)
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