Patient-derived models of acquired resistance can identify effective drug combinations for cancer
Crystal, Adam S., Shaw, Alice T., Sequist, Lecia V., Friboulet, Luc, Niederst, Matthew J., Lockerman, Elizabeth L., Frias, Rosa L., Gainor, Justin F., Amzallag, Arnaud, Greninger, Patricia, Lee, Dana, Kalsy, Anuj, Gomez-Caraballo, Maria, Elamine, Leila, Howe, Emily, Hur, Wooyoung, Lifshits, Eugene, Robinson, Hayley E., Katayama, Ryohei, Faber, Anthony C., Awad, Mark M., Ramaswamy, Sridhar, Mino-Kenudson, Mari, Iafrate, A. John, Benes, Cyril H., Engelman, Jeffrey A.
Published in Science (American Association for the Advancement of Science) (19.12.2014)
Published in Science (American Association for the Advancement of Science) (19.12.2014)
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Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
Katayama, Ryohei, Khan, Tahsin M., Benes, Cyril, Lifshits, Eugene, Ebi, Hiromichi, Rivera, Victor M., Shakespeare, William C., Iafrate, A. John, Engelman, Jeffrey A., Shaw, Alice T., Vogt, Peter K.
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2011)
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PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models
Zou, Helen Y., Friboulet, Luc, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Katayama, Ryohei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Frias, Rosa L., Lifshits, Eugene, Mahmood, Sidra, Gainor, Justin F., Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC
Turke, Alexa B., Zejnullahu, Kreshnik, Wu, Yi-Long, Song, Youngchul, Dias-Santagata, Dora, Lifshits, Eugene, Toschi, Luca, Rogers, Andrew, Mok, Tony, Sequist, Lecia, Lindeman, Neal I., Murphy, Carly, Akhavanfard, Sara, Yeap, Beow Y., Xiao, Yun, Capelletti, Marzia, Iafrate, A. John, Lee, Charles, Christensen, James G., Engelman, Jeffrey A., Jänne, Pasi A.
Published in Cancer cell (19.01.2010)
Published in Cancer cell (19.01.2010)
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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
Yonesaka, Kimio, Zejnullahu, Kreshnik, Okamoto, Isamu, Satoh, Taroh, Cappuzzo, Federico, Souglakos, John, Ercan, Dalia, Rogers, Andrew, Roncalli, Massimo, Takeda, Masayuki, Fujisaka, Yasuhito, Philips, Juliet, Shimizu, Toshio, Maenishi, Osamu, Cho, Yonggon, Sun, Jason, Destro, Annarita, Taira, Koichi, Takeda, Koji, Okabe, Takafumi, Swanson, Jeffrey, Itoh, Hiroyuki, Takada, Minoru, Lifshits, Eugene, Okuno, Kiyotaka, Engelman, Jeffrey A, Shivdasani, Ramesh A, Nishio, Kazuto, Fukuoka, Masahiro, Varella-Garcia, Marileila, Nakagawa, Kazuhiko, Jänne, Pasi A
Published in Science translational medicine (07.09.2011)
Published in Science translational medicine (07.09.2011)
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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models
Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Hung, Kenneth E., Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.
Published in Cancer cell (14.01.2013)
Published in Cancer cell (14.01.2013)
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Multiple Mutations and Bypass Mechanisms Can Contribute to Development of Acquired Resistance to MET Inhibitors
JIE QI, MCTIGUE, Michele A, ROGERS, Andrew, LIFSHITS, Eugene, CHRISTENSEN, James G, JÄNNE, Pasi A, ENGELMAN, Jeffrey A
Published in Cancer research (Chicago, Ill.) (01.02.2011)
Published in Cancer research (Chicago, Ill.) (01.02.2011)
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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
Ebi, Hiromichi, Corcoran, Ryan B, Singh, Anurag, Chen, Zhao, Song, Youngchul, Lifshits, Eugene, Ryan, David P, Meyerhardt, Jeffrey A, Benes, Cyril, Settleman, Jeffrey, Wong, Kwok-Kin, Cantley, Lewis C, Engelman, Jeffrey A
Published in The Journal of clinical investigation (01.11.2011)
Published in The Journal of clinical investigation (01.11.2011)
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EML4-ALK Fusion Gene and Efficacy of an ALK Kinase Inhibitor in Lung Cancer
KOIVUNEN, Jussi P, MERMEL, Craig, LEE, Jinseon, RICHARDS, William G, SUGARBAKER, David J, DUCKO, Christopher, LINDEMAN, Neal, MARCOUX, J. Paul, ENGELMAN, Jeffrey A, GRAY, Nathanael S, LEE, Charles, MEYERSON, Matthew, ZEJNULLAHU, Kreshnik, JDNNE, Pasi A, MURPHY, Carly, LIFSHITS, Eugene, HOLMES, Alison J, HWAN GEUN CHOI, KIRN, Jhingook, CHIANG, Derek, THOMAS, Roman
Published in Clinical cancer research (01.07.2008)
Published in Clinical cancer research (01.07.2008)
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Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
Faber, Anthony C, Li, Danan, Song, YoungChul, Liang, Mei-Chih, Yeap, Beow Y, Bronson, Roderick T, Lifshits, Eugene, Chen, Zhao, Maira, Sauveur-Michel, García-Echeverría, Carlos, Wong, Kwok-Kin, Engelman, Jeffrey A
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.11.2009)
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Combined Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor (EGFR) Blockade Inhibits Tumor Growth in Xenograft Models of EGFR Inhibitor Resistance
NAUMOV, George N, NILSSON, Monique B, JÄNNE, Pasi, KOBAYASHI, Susumu, HALMOS, Balazs, TENEN, Daniel, TANG, Xi M, ENGELMAN, Jeffrey, YEAP, Beow, FOLKMAN, Judah, JOHNSON, Bruce E, HEYMACH, John V, CASCONE, Tina, BRIGGS, Alexandra, STRAUME, Oddbjorn, AKSLEN, Lars A, LIFSHITS, Eugene, AVERETT BYERS, Lauren, LI XU, WU, Hua-Kang
Published in Clinical cancer research (15.05.2009)
Published in Clinical cancer research (15.05.2009)
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BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors
Faber, Anthony C, Corcoran, Ryan B, Ebi, Hiromichi, Sequist, Lecia V, Waltman, Belinda A, Chung, Euiheon, Incio, Joao, Digumarthy, Subba R, Pollack, Sarah F, Song, Youngchul, Muzikansky, Alona, Lifshits, Eugene, Roberge, Sylvie, Coffman, Erik J, Benes, Cyril H, Gómez, Henry L, Baselga, José, Arteaga, Carlos L, Rivera, Miguel N, Dias-Santagata, Dora, Jain, Rakesh K, Engelman, Jeffrey A
Published in Cancer discovery (01.09.2011)
Published in Cancer discovery (01.09.2011)
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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
HATA, Aaron N, YEO, Alan, MINO-KENUDSON, Mari, WONG, Kwok-Kin, ENGELMAN, Jeffrey A, FABER, Anthony C, LIFSHITS, Eugene, ZHAO CHEN, CHENG, Katherine A, WALTON, Zandra, SAROSIEK, Kristopher A, LETAI, Anthony, HEIST, Rebecca S
Published in Cancer research (Chicago, Ill.) (01.06.2014)
Published in Cancer research (Chicago, Ill.) (01.06.2014)
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Class 1A PI3K regulates vessel integrity during development and tumorigenesis
Yuan, Tina L, Choi, Hak Soo, Matsui, Aya, Benes, Cyril, Lifshits, Eugene, Luo, Ji, Frangioni, John V, Cantley, Lewis C
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (15.07.2008)
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Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors
Rogers, Michael S, Novak, Katherine, Zurakowski, David, Cryan, Lorna M, Blois, Anna, Lifshits, Eugene, Bø, Trond H, Oyan, Anne M, Bender, Elise R, Lampa, Michael, Kang, Soo-Young, Naxerova, Kamila, Kalland, Karl-Henning, Straume, Oddbjorn, Akslen, Lars A, Watnick, Randolph S, Folkman, Judah, Naumov, George N
Published in Molecular cancer research (01.05.2014)
Published in Molecular cancer research (01.05.2014)
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PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib
ENGELMAN, Jeffrey A, ZEJNULLAHU, Kreshnik, ALTHAUS, Irene W, GANDHI, Leena, SHAPIRO, Geoffrey I, NELSON, James M, HEYMACH, John V, MEYERSON, Matthew, WONG, Kwok-Kin, JÄNNE, Pasi A, GALE, Christopher-Michael, LIFSHITS, Eugene, GONZALES, Andrea J, SHIMAMURA, Takeshi, FENG ZHAO, VINCENT, Patrick W, NAUMOV, George N, BRADNER, James E
Published in Cancer research (Chicago, Ill.) (15.12.2007)
Published in Cancer research (Chicago, Ill.) (15.12.2007)
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Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor
ERCAN, D, ZEJNULLAHU, K, KWIATKOWSKI, D. J, ENGELMAN, J. A, JÄNNE, P. A, YONESAKA, K, XIAO, Y, CAPELLETTI, M, ROGERS, A, LIFSHITS, E, BROWN, A, LEE, C, CHRISTENSEN, J. G
Published in Oncogene (22.04.2010)
Published in Oncogene (22.04.2010)
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Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
Engelman, Jeffrey A, Mukohara, Toru, Zejnullahu, Kreshnik, Lifshits, Eugene, Borrás, Ana M, Gale, Christopher-Michael, Naumov, George N, Yeap, Beow Y, Jarrell, Emily, Sun, Jason, Tracy, Sean, Zhao, Xiaojun, Heymach, John V, Johnson, Bruce E, Cantley, Lewis C, Jänne, Pasi A
Published in The Journal of clinical investigation (01.10.2006)
Published in The Journal of clinical investigation (01.10.2006)
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Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells
Amin, Dhara N., Bielenberg, Diane R., Lifshits, Eugene, Heymach, John V., Klagsbrun, Michael
Published in Microvascular research (01.05.2008)
Published in Microvascular research (01.05.2008)
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Journal Article
Abstract 130: PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical models
Friboulet, Luc, Zou, Helen, Kodack, David P., Engstrom, Lars D., Li, Qiuhua, West, Melissa, Tang, Ruth W., Wang, Hui, Tsaparikos, Konstantinos, Wang, Jinwei, Timofeevski, Sergei, Dinh, Dac M., Lam, Hieu, Lam, Justine L., Yamazaki, Shinji, Hu, Wenyue, Patel, Bhushankumar, Bezwada, Divya, Mahmood, Sidra, Lifshits, Eugene, Affolter, Timothy, Lappin, Patrick B., Gukasyan, Hovhannes, Lee, Nathan, Deng, Shibing, Jain, Rakesh K., Johnson, Ted W., Shaw, Alice T., Fantin, Valeria R., Smeal, Tod
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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