Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer
Leal, Ana S, Williams, Charlotte R, Royce, Darlene B, Pioli, Patricia A, Sporn, Michael B, Liby, Karen T
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Published in Cancer letters (28.05.2017)
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New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
Sporn, Michael B, Liby, Karen T, Yore, Mark M, Fu, Liangfeng, Lopchuk, Justin M, Gribble, Gordon W
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Published in Journal of natural products (Washington, D.C.) (25.03.2011)
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Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
Neymotin, Arie, Calingasan, Noel Y., Wille, Elizabeth, Naseri, Nima, Petri, Susanne, Damiano, Maria, Liby, Karen T., Risingsong, Renee, Sporn, Michael, Beal, M. Flint, Kiaei, Mahmoud
Published in Free radical biology & medicine (01.07.2011)
Published in Free radical biology & medicine (01.07.2011)
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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide
Shin, Soona, Wakabayashi, Junko, Yates, Melinda S., Wakabayashi, Nobunao, Dolan, Patrick M., Aja, Susan, Liby, Karen T., Sporn, Michael B., Yamamoto, Masayuki, Kensler, Thomas W.
Published in European journal of pharmacology (12.10.2009)
Published in European journal of pharmacology (12.10.2009)
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Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis
To, Ciric, Ringelberg, Carol S, Royce, Darlene B, Williams, Charlotte R, Risingsong, Renee, Sporn, Michael B, Liby, Karen T
Published in Carcinogenesis (New York) (01.07.2015)
Published in Carcinogenesis (New York) (01.07.2015)
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Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR
Yore, Mark M, Kettenbach, Arminja N, Sporn, Michael B, Gerber, Scott A, Liby, Karen T
Published in PloS one (27.07.2011)
Published in PloS one (27.07.2011)
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Sustained, local delivery of the PARP inhibitor talazoparib prevents the development of mammary gland hyperplasia in Brca1-deficient mice
Zhang, Di, Singh, Bijay, Moerland, Jessica, Mitchell, Owen, Lockwood, Lizbeth, Carapellucci, Sarah, Sridhar, Srinivas, Liby, Karen T
Published in Scientific reports (13.01.2021)
Published in Scientific reports (13.01.2021)
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Targeting Nrf2 with the Triterpenoid CDDO-Imidazolide Attenuates Cigarette Smoke-Induced Emphysema and Cardiac Dysfunction in Mice
Sussan, Thomas E., Rangasamy, Tirumalai, Blake, David J., Malhotra, Deepti, El-Haddad, Hazim, Bedja, Djahida, Yates, Melinda S., Kombairaju, Ponvijay, Yamamoto, Masayuki, Liby, Karen T., Sporn, Michael B., Gabrielson, Kathleen L., Champion, Hunter C., Tuder, Rubin M., Kensler, Thomas W., Biswal, Shyam, Wogan, Gerald N.
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (06.01.2009)
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The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis
Occhiuto, Christopher J, Moerland, Jessica A, Leal, Ana S, Gallo, Kathleen A, Liby, Karen T
Published in Molecules and cells (01.03.2023)
Published in Molecules and cells (01.03.2023)
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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
Yates, Melinda S., Tran, Quynh T., Dolan, Patrick M., Osburn, William O., Shin, Soona, McCulloch, Colin C., Silkworth, Jay B., Taguchi, Keiko, Yamamoto, Masayuki, Williams, Charlotte R., Liby, Karen T., Sporn, Michael B., Sutter, Thomas R., Kensler, Thomas W.
Published in Carcinogenesis (New York) (01.06.2009)
Published in Carcinogenesis (New York) (01.06.2009)
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The RXR Agonist MSU42011 Is Effective for the Treatment of Preclinical HER2+ Breast Cancer and Kras-Driven Lung Cancer
Leal, Ana S., Moerland, Jessica A., Zhang, Di, Carapellucci, Sarah, Lockwood, Beth, Krieger-Burke, Teresa, Aleiwi, Bilal, Ellsworth, Edmund, Liby, Karen T.
Published in Cancers (06.10.2021)
Published in Cancers (06.10.2021)
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Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription
Yang, Lichuan, Calingasan, Noel Y, Thomas, Bobby, Chaturvedi, Rajnish K, Kiaei, Mahmoud, Wille, Elizabeth J, Liby, Karen T, Williams, Charlotte, Royce, Darlene, Risingsong, Renee, Musiek, Eric S, Morrow, Jason D, Sporn, Michael, Beal, M Flint
Published in PloS one (01.06.2009)
Published in PloS one (01.06.2009)
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The novel rexinoid MSU-42011 is effective for the treatment of preclinical Kras-driven lung cancer
Moerland, Jessica A, Zhang, Di, Reich, Lyndsey A, Carapellucci, Sarah, Lockwood, Beth, Leal, Ana S, Krieger-Burke, Teresa, Aleiwi, Bilal, Ellsworth, Edmund, Liby, Karen T
Published in Scientific reports (17.12.2020)
Published in Scientific reports (17.12.2020)
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Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease
Kaidery, Navneet Ammal, Banerjee, Rebecca, Yang, Lichuan, Smirnova, Natalya A, Hushpulian, Dmitry M, Liby, Karen T, Williams, Charlotte R, Yamamoto, Masayuki, Kensler, Thomas W, Ratan, Rajiv R, Sporn, Michael B, Beal, M Flint, Gazaryan, Irina G, Thomas, Bobby
Published in Antioxidants & redox signaling (10.01.2013)
Published in Antioxidants & redox signaling (10.01.2013)
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The rexinoid V-125 reduces tumor growth in preclinical models of breast and lung cancer
Reich, Lyndsey A, Moerland, Jessica A, Leal, Ana S, Zhang, Di, Carapellucci, Sarah, Lockwood, Beth, Jurutka, Peter W, Marshall, Pamela A, Wagner, Carl E, Liby, Karen T
Published in Scientific reports (07.01.2022)
Published in Scientific reports (07.01.2022)
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