Self-renewal as a therapeutic target in human colorectal cancer
Kreso, Antonija, van Galen, Peter, Pedley, Nicholas M, Lima-Fernandes, Evelyne, Frelin, Catherine, Davis, Thomas, Cao, Liangxian, Baiazitov, Ramil, Du, Wu, Sydorenko, Nadiya, Moon, Young-Choon, Gibson, Lianne, Wang, Yadong, Leung, Cherry, Iscove, Norman N, Arrowsmith, Cheryl H, Szentgyorgyi, Eva, Gallinger, Steven, Dick, John E, O'Brien, Catherine A
Published in Nature medicine (01.01.2014)
Published in Nature medicine (01.01.2014)
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Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer
Dey, Anindya, Xiong, Xunhao, Crim, Aleia, Dwivedi, Shailendra Kumar Dhar, Mustafi, Soumyajit Banerjee, Mukherjee, Priyabrata, Cao, Liangxian, Sydorenko, Nadiya, Baiazitov, Ramil, Moon, Young-Choon, Dumble, Melissa, Davis, Thomas, Bhattacharya, Resham
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines
Luban, Jeremy, Sattler, Rachel A., Mühlberger, Elke, Graci, Jason D., Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Colacino, Joseph M., Bavari, Sina, Strambio-De-Castillia, Caterina, Suder, Ellen L., Wang, Yetao, Soloveva, Veronica, Cintron-Lue, Katherine, Naryshkin, Nikolai A., Pykett, Mark, Welch, Ellen M., O’Keefe, Kylie, Kong, Ronald, Goodwin, Elizabeth, Jacobson, Allan, Paessler, Slobodan, Peltz, Stuart W.
Published in Virus research (15.01.2021)
Published in Virus research (15.01.2021)
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Preclinical and Early Clinical Development of PTC596, a Novel Small-Molecule Tubulin-Binding Agent
Jernigan, Finith, Branstrom, Arthur, Baird, John D, Cao, Liangxian, Dali, Mandar, Furia, Bansri, Kim, Min Jung, O'Keefe, Kylie, Kong, Ronald, Laskin, Oscar L, Colacino, Joseph M, Pykett, Mark, Mollin, Anna, Sheedy, Josephine, Dumble, Melissa, Moon, Young-Choon, Sheridan, Richard, Mühlethaler, Tobias, Spiegel, Robert J, Prota, Andrea E, Steinmetz, Michel O, Weetall, Marla
Published in Molecular cancer therapeutics (01.10.2021)
Published in Molecular cancer therapeutics (01.10.2021)
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Inhibition of BMI1, a Therapeutic Approach in Endometrial Cancer
Buechel, Megan, Dey, Anindya, Dwivedi, Shailendra Kumar Dhar, Crim, Aleia, Ding, Kai, Zhang, Roy, Mukherjee, Priyabrata, Moore, Kathleen N, Cao, Liangxian, Branstrom, Arthur, Weetall, Marla, Baird, John, Bhattacharya, Resham
Published in Molecular cancer therapeutics (01.10.2018)
Published in Molecular cancer therapeutics (01.10.2018)
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BMI1 is a therapeutic target in recurrent medulloblastoma
Bakhshinyan, David, Venugopal, Chitra, Adile, Ashley A., Garg, Neha, Manoranjan, Branavan, Hallett, Robin, Wang, Xin, Mahendram, Sujeivan, Vora, Parvez, Vijayakumar, Thusyanth, Subapanditha, Minomi, Singh, Mohini, Kameda-Smith, Michelle Masayo, Qazi, Maleeha, McFarlane, Nicole, Mann, Aneet, Ajani, Olufemi A., Yarascavitch, Blake, Ramaswamy, Vijay, Farooq, Hamza, Morrissy, Sorana, Cao, Liangxian, Sydorenko, Nadiya, Baiazitov, Ramil, Du, Wu, Sheedy, Josephine, Weetall, Marla, Moon, Young-Choon, Lee, Chang-Sun, Kwiecien, Jacek M., Delaney, Kathleen H., Doble, Brad, Cho, Yoon-Jae, Mitra, Siddhartha, Kaplan, David, Taylor, Michael D., Davis, Thomas W., Singh, Sheila K.
Published in Oncogene (01.03.2019)
Published in Oncogene (01.03.2019)
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Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia
Branstrom, Arthur, Cao, Liangxian, Furia, Bansri, Trotta, Christopher, Santaguida, Marianne, Graci, Jason D, Colacino, Joseph M, Ray, Balmiki, Li, Wencheng, Sheedy, Josephine, Mollin, Anna, Yeh, Shirley, Kong, Ronald, Sheridan, Richard, Baird, John D, O'Keefe, Kylie, Spiegel, Robert, Goodwin, Elizabeth, Keating, Suzanne, Weetall, Marla
Published in Frontiers in oncology (09.02.2022)
Published in Frontiers in oncology (09.02.2022)
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Targeting of BMI-1 expression by the novel small molecule PTC596 in mantle cell lymphoma
Maeda, Aya, Nishida, Yuki, Weetall, Marla, Cao, Liangxian, Branstrom, Arthur, Ishizawa, Jo, Nii, Takenobu, Schober, Wendy D, Abe, Yoshiaki, Matsue, Kosei, Yoshimura, Mariko, Kimura, Shinya, Kojima, Kensuke
Published in Oncotarget (19.06.2018)
Published in Oncotarget (19.06.2018)
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Discovery of Novel Small Molecule Inhibitors of VEGF Expression in Tumor Cells Using a Cell-Based High Throughput Screening Platform
Cao, Liangxian, Weetall, Marla, Bombard, Jenelle, Qi, Hongyan, Arasu, Tamil, Lennox, William, Hedrick, Jean, Sheedy, Josephine, Risher, Nicole, Brooks, Peter C, Trifillis, Panayiota, Trotta, Christopher, Moon, Young-Choon, Babiak, John, Almstead, Neil G, Colacino, Joseph M, Davis, Thomas W, Peltz, Stuart W
Published in PloS one (16.12.2016)
Published in PloS one (16.12.2016)
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BMI1 as a novel target for drug discovery in cancer
Cao, Liangxian, Bombard, Jenelle, Cintron, Katherine, Sheedy, Josephine, Weetall, Marla L., Davis, Thomas W.
Published in Journal of cellular biochemistry (01.10.2011)
Published in Journal of cellular biochemistry (01.10.2011)
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Journal Article
Abstract 5517: PTC596-induced Bmi1 hyper-phosphorylation via Cdk1/2 activation resulting in tumor stem cell depletion
Kim, Min Jung, Cao, Liangxian, Sheedy, Josephine, Risher, Nicole, Dumble, Melissa, Lee, Chang-Sun, Sydorenko, Nadiya, Baiazitov, Ramil, Du, Wu, Moon, Young-Choon, Weetall, Marla L., Colacino, Joseph, Davis, Thomas W.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation
Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spiegel, Robert, Peltz, Stuart W.
Published in Clinical pharmacology in drug development (01.07.2016)
Published in Clinical pharmacology in drug development (01.07.2016)
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BMI1 as a novel target for drug discovery in cancer
Cao, Liangxian, Bombard, Jenelle, Cintron, Katherine, Sheedy, Josephine, Weetall, Marla L., Davis, Thomas W.
Published in Journal of cellular biochemistry (01.10.2011)
Published in Journal of cellular biochemistry (01.10.2011)
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Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties
Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Cintron, Katherine, Ma, Jiyuan, Kim, Min Jung, Furia, Bansri, Romfo, Charles, Graci, Jason D, Li, Wencheng, Du, Joshua, Sheedy, Josephine, Hedrick, Jean, Risher, Nicole, Yeh, Shirley, Qi, Hongyan, Arasu, Tamil, Hwang, Seongwoo, Lennox, William, Kong, Ronald, Petruska, Janet, Moon, Young-Choon, Babiak, John, Davis, Thomas W, Jacobson, Allan, Almstead, Neil G, Branstrom, Art, Colacino, Joseph M, Peltz, Stuart W
Published in Molecular cancer therapeutics (01.01.2019)
Published in Molecular cancer therapeutics (01.01.2019)
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Preclinical studies of gene replacement therapy for CDKL5 deficiency disorder
Voronin, Gregory, Narasimhan, Jana, Gittens, Jamila, Sheedy, Josephine, Lipari, Philip, Peters, Melinda, DeMarco, Steven, Cao, Liangxian, Varganov, Yakov, Kim, Min Jung, Pear, Lisset, Fotouh, Eman, Sinha, Supriya, Ray, Balmiki, Wu, Michael C., Yalamanchili, Padmaja, Southgate, Christopher, Pick, Joseph, Saadipour, Khalil, Jung, Stephen, Lee, Jeanee, Mollin, Anna, Welch, Ellen M., Wu, Zhijian, Weetall, Marla
Published in Molecular therapy (02.10.2024)
Published in Molecular therapy (02.10.2024)
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Journal Article
SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor
Baiazitov, Ramil Y., Qi, Hongyan, Arasu, Tamil, Lennox, William, Cao, Liangxian, Weetall, Marla, Furia, Bansri, Zhuo, Jin, Choi, Soongyu, Kim, Min Jung, Sheedy, Josephine, Davis, Thomas, Moon, Young-Choon
Published in European journal of medicinal chemistry (15.12.2022)
Published in European journal of medicinal chemistry (15.12.2022)
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Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma
Eberle-Singh, Jaime A, Sagalovskiy, Irina, Maurer, H Carlo, Sastra, Stephen A, Palermo, Carmine F, Decker, Amanda R, Kim, Min Jung, Sheedy, Josephine, Mollin, Anna, Cao, Liangxian, Hu, Jianhua, Branstrom, Arthur, Weetall, Marla, Olive, Kenneth P
Published in Clinical cancer research (15.09.2019)
Published in Clinical cancer research (15.09.2019)
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Journal Article
The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines
Luban, Jeremy, Sattler, Rachel, Mühlberger, Elke, Graci, Jason D, Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Colacino, Joseph M, Bavari, Sina, Strambio-De-Castillia, Caterina, Suder, Ellen L, Wang, Yetao, Soloveva, Veronica, Cintron-Lue, Katherine, Naryshkin, Nikolai A, Pykett, Mark, Welch, Ellen M, O'Keefe, Kylie, Kong, Ronald, Goodwin, Elizabeth, Jacobson, Allan, Paessler, Slobodan, Peltz, Stuart
Published in bioRxiv (05.08.2020)
Published in bioRxiv (05.08.2020)
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BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer
Bansal, Nitu, Bartucci, Monica, Yusuff, Shamila, Davis, Stephani, Flaherty, Kathleen, Huselid, Eric, Patrizii, Michele, Jones, Daniel, Cao, Liangxian, Sydorenko, Nadiya, Moon, Young-Choon, Zhong, Hua, Medina, Daniel J, Kerrigan, John, Stein, Mark N, Kim, Isaac Y, Davis, Thomas W, DiPaola, Robert S, Bertino, Joseph R, Sabaawy, Hatem E
Published in Clinical cancer research (15.12.2016)
Published in Clinical cancer research (15.12.2016)
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Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
Yong, Kol Jia, Basseres, Daniela S, Welner, Robert S, Zhang, Wen Cai, Yang, Henry, Yan, Benedict, Alberich-Jorda, Meritxell, Zhang, Junyan, de Figueiredo-Pontes, Lorena Lobo, Battelli, Chiara, Hetherington, Christopher J, Ye, Min, Zhang, Hong, Maroni, Giorgia, O'Brien, Karen, Magli, Maria Cristina, Borczuk, Alain C, Varticovski, Lyuba, Kocher, Olivier, Zhang, Pu, Moon, Young-Choon, Sydorenko, Nadiya, Cao, Liangxian, Davis, Thomas W, Thakkar, Bhavin M, Soo, Ross A, Iwama, Atsushi, Lim, Bing, Halmos, Balazs, Neuberg, Donna, Tenen, Daniel G, Levantini, Elena
Published in Science translational medicine (03.08.2016)
Published in Science translational medicine (03.08.2016)
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