Convergent Synthesis of a 5HT7/5HT2 Dual Antagonist
Liang, Jimmy T, Deng, Xiaohu, Mani, Neelakandha S
Published in Organic process research & development (15.07.2011)
Published in Organic process research & development (15.07.2011)
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Journal Article
Practical Synthesis of a Cathepsin S Inhibitor: Route Identification, Purification Strategies, and Serendipitous Discovery of a Crystalline Salt Form
Deng, Xiaohu, Liang, Jimmy T, Peterson, Matthew, Rynberg, Raymond, Cheung, Eugene, Mani, Neelakandha S
Published in Journal of organic chemistry (19.03.2010)
Published in Journal of organic chemistry (19.03.2010)
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Journal Article
Design of Concise, Scalable Route to a Cholecystokinin 1 (CCK 1) Receptor Antagonist
Liang, Jimmy T, Mani, Neelakandha S, Jones, Todd K
Published in Journal of organic chemistry (26.10.2007)
Published in Journal of organic chemistry (26.10.2007)
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Journal Article
Identification of benzofuran central cores for the inhibition of leukotriene A4 hydrolase
Eccles, Wendy, Blevitt, Jonathan M., Booker, Jamila N., Chrovian, Christa C., Crawford, Shelby, de Leon, Aimee Rose, Deng, Xiaohu, Fourie, Anne M., Grice, Cheryl A., Herman, Krystal, Karlsson, Lars, Kearney, Aaron M., Lee-Dutra, Alice, Liang, Jimmy, Luna, Rosa, Pippel, Dan, Rao, Navin, Riley, Jason P., Santillán, Alejandro, Savall, Brad, Tanis, Virginia M., Xue, Xiaohua, Young, Arlene L.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
A Practical Synthesis of Regioisomeric 6- and 7-Methoxytetrahydro-3-benzazepines
Liang, Jimmy T, Liu, Jing, Shireman, Brock T, Tran, Vi, Deng, Xiaohu, Mani, Neelakandha S
Published in Organic process research & development (19.03.2010)
Published in Organic process research & development (19.03.2010)
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Journal Article
Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzy1-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine
Dvorak, Curt A., Liang, Jimmy, Mani, Neelakandha S., Carruthers, Nicholas
Published in Tetrahedron letters (16.03.2021)
Published in Tetrahedron letters (16.03.2021)
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Journal Article
Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine
Dvorak, Curt A., Liang, Jimmy, Mani, Neelakandha S., Carruthers, Nicholas I.
Published in Tetrahedron letters (16.03.2021)
Published in Tetrahedron letters (16.03.2021)
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Journal Article
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors
Allison, Brett D., Deng, Xiaohu, Li, Lian-Sheng, Liang, Jimmy, Mani, Neelakandha S., Ren, Pingda, Sales, Zachary S.
Published in Organic process research & development (21.10.2022)
Published in Organic process research & development (21.10.2022)
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Journal Article
4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
Allyl-Assisted, Cu(I)-Catalyzed Azide–Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure
Deng, Xiaohu, Liang, Jimmy, Allison, Brett B, Dvorak, Curt, McAllister, Heather, Savall, Brad M, Mani, Neelakandha S
Published in Journal of organic chemistry (06.11.2015)
Published in Journal of organic chemistry (06.11.2015)
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Journal Article
모노아실글리세롤 리파아제 조절제
LAFORTEZA BRIAN NGO, AMERIKS MICHAEL K, BERRY CYNTHIA B, LIANG JIMMY T, GARCIA REYNAGA PABLO
Year of Publication 18.10.2022
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Year of Publication 18.10.2022
Patent
Convergent Synthesis of a 5HT(7)/5HT(2) Dual Antagonist
Liang, Jimmy T., Deng, Xiaohu, Mani, Neelakandha S.
Published in Organic process research & development (01.07.2011)
Published in Organic process research & development (01.07.2011)
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Journal Article
4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A., Savall, Brad M., Allison, Brett D., Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A., Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I., Ceusters, Marc, Coe, Kevin J., Dvorak, Curt A., Fraser, Ian C., Gelin, Christine F., Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W., Otieno, Monicah A., Schoetens, Freddy, Swanson, Devin M., Wang, Qi, Wickenden, Alan D., Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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Journal Article
P2X7 P2X7 MODULATORS
DENG XIAOHU, SAVALL BRAD M, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, STENNE BRICE M, GELIN CHRISTINE F, DVORAK CURT A, SWANSON DEVIN M, COATE HEATHER R, SOYODE JOHNSON AKINOLA, DE ANGELIS MERI, ALLISON BRETT D, LETAVIC MICHAEL A, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, RECH JASON C, WALL JESSICA L
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
Patent
Convergent Synthesis of a 5HT 7 /5HT 2 Dual Antagonist
Liang, Jimmy T., Deng, Xiaohu, Mani, Neelakandha S.
Published in Organic process research & development (15.07.2011)
Published in Organic process research & development (15.07.2011)
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Journal Article
P2X7 P2X7 MODULATORS
DENG XIAOHU, SAVALL BRAD M, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, STENNE BRICE M, GELIN CHRISTINE F, DVORAK CURT A, SWANSON DEVIN M, COATE HEATHER R, DE ANGELIS MERI, SOYODEJOHNSON AKINOLA, ALLISON BRETT D, LETAVIC MICHAEL A, CHROVIAN CHRISTA C, LIANG JIMMY T, MANI NEELAKANDHA S, RECH JASON C, WALL JESSICA L
Year of Publication 07.04.2022
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Year of Publication 07.04.2022
Patent
A Practical Synthesis of Enantiopure 7-Alkoxy-4-aryl-tetrahydroisoquinoline, a Dual Serotonin Reuptake Inhibitor/Histamine H 3 Antagonist
Deng, Xiaohu, Liang, Jimmy T., Liu, Jing, McAllister, Heather, Schubert, Carsten, Mani, Neelakandha S.
Published in Organic process research & development (01.11.2007)
Published in Organic process research & development (01.11.2007)
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Journal Article