Structure-based library design and the discovery of a potent and selective mast cell β-tryptase inhibitor as an oral therapeutic agent
Liang, Guyan, Aldous, Suzanne, Merriman, Gregory, Levell, Julian, Pribish, James, Cairns, Jennifer, Chen, Xin, Maignan, Sebastien, Mathieu, Magali, Tsay, Joseph, Sides, Keith, Rebello, Sam, Whitely, Brian, Morize, Isabelle, Pauls, Henry W.
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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A β-tryptase inhibitor with a tropanylamide scaffold to improve in vitro stability and to lower hERG channel binding affinity
Liang, Guyan, Choi-Sledeski, Yong Mi, Shum, Patrick, Chen, Xin, Poli, Gregory B., Kumar, Vasant, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Kang, Jiesheng, Zhang, Ying
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P1 Ligand
Choi-Sledeski, Yong Mi, Kearney, Robert, Poli, Gregory, Pauls, Henry, Gardner, Charles, Gong, Yong, Becker, Michael, Davis, Roderick, Spada, Alfred, Liang, Guyan, Chu, Valeria, Brown, Karen, Collussi, Dennis, Leadley, Robert, Rebello, Sam, Moxey, Phillip, Morgan, Suzanne, Bentley, Ross, Kasiewski, Charles, Maignan, Sebastien, Guilloteau, Jean-Pierre, Mikol, Vincent
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Journal Article
A conformationally constrained inhibitor with an enhanced potency for β-tryptase and stability against semicarbazide-sensitive amine oxidase (SSAO)
Liang, Guyan, Choi-Sledeski, Yong Mi, Poli, Gregory, Chen, Xin, Shum, Patrick, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Cairns, Jennifer, Stoklosa, Gregory, Nieduzak, Thaddeus, Zhao, Zhicheng, Wang, Jie, Vaz, Roy J.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Journal Article
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase
Hopkins, Corey R., Czekaj, Mark, Kaye, Steven S., Gao, Zhongli, Pribish, James, Pauls, Henry, Liang, Guyan, Sides, Keith, Cramer, Dona, Cairns, Jennifer, Luo, Yongyi, Lim, Heng-Keang, Vaz, Roy, Rebello, Sam, Maignan, Sebastian, Dupuy, Alain, Mathieu, Magali, Levell, Julian
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
Novel pyrazinone inhibitors of mast cell tryptase: synthesis and SAR evaluation
Hopkins, Corey, Neuenschwander, Kent, Scotese, Anthony, Jackson, Sharon, Nieduzak, Thaddeus, Pauls, Henry, Liang, Guyan, Sides, Keith, Cramer, Dona, Cairns, Jennifer, Maignan, Sebastien, Mathieu, Magali
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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Journal Article
Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase
Jackson, Sharon A., Sahni, Sukhveen, Lee, Lan, Luo, Yongyi, Nieduzak, Thaddeus R., Liang, Guyan, Chiang, Yulin, Collar, Nicola, Fink, David, He, Wei, Laoui, Abdelazize, Merrill, Jean, Boffey, Ray, Crackett, Peter, Rees, Bryan, Wong, Melanie, Guilloteau, Jean-Pierre, Mathieu, Magali, Rebello, Sam S.
Published in Bioorganic & medicinal chemistry (15.04.2005)
Published in Bioorganic & medicinal chemistry (15.04.2005)
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Journal Article
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase
Levell, Julian, Astles, Peter, Eastwood, Paul, Cairns, Jennifer, Houille, Olivier, Aldous, Suzanne, Merriman, Gregory, Whiteley, Brian, Pribish, James, Czekaj, Mark, Liang, Guyan, Maignan, Sebastien, Guilloteau, Jean-Pierre, Dupuy, Alain, Davidson, Jane, Harrison, Trevor, Morley, Andrew, Watson, Simon, Fenton, Garry, McCarthy, Clive, Romano, Joseph, Mathew, Rose, Engers, Darren, Gardyan, Michael, Sides, Keith, Kwong, Jennifer, Tsay, Joseph, Rebello, Sam, Shen, Liduo, Wang, Jie, Luo, Yongyi, Giardino, Odessa, Lim, Heng-Keang, Smith, Keith, Pauls, Henry
Published in Bioorganic & medicinal chemistry (15.04.2005)
Published in Bioorganic & medicinal chemistry (15.04.2005)
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Journal Article
Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors
He, Wei, Huang, Fu-Chih, Hanney, Barbara, Souness, John, Miller, Bruce, Liang, Guyan, Mason, Jon, Djuric, Stevan
Published in Journal of medicinal chemistry (22.10.1998)
Published in Journal of medicinal chemistry (22.10.1998)
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섬유아세포 활성화 단백질(FAP)과 결합하는 방사성 트레이서들 및 치료제들
RAHMAN SABITUR, BARNES COLIN, HAJI ABDUL KARIM, BEJOT ROMAIN, LIANG GUYAN
Year of Publication 15.03.2024
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Year of Publication 15.03.2024
Patent
Amido-(propyl and allyl)-hydroxybenzamidines : Development of achiral inhibitors of factor Xa
YONG GONG, PAULS, H. W, SPADA, A. P, CZEKAJ, M, GUYAN LIANG, CHU, V, COLUSSI, D. J, BROWN, K. D, JINGBO GAO
Published in Bioorganic & medicinal chemistry letters (07.02.2000)
Published in Bioorganic & medicinal chemistry letters (07.02.2000)
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Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
Liang, Guyan, Chen, Xin, Aldous, Suzanne, Pu, Su-Fen, Mehdi, Shujaath, Powers, Elaine, Xia, Tianhui, Wang, Rachel
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Journal Article
Dimerization of β-tryptase inhibitors, does it work for both basic and neutral P1 groups?
Liang, Guyan, Choi-Sledeski, Yong Mi, Chen, Xin, Gong, Yong, MacMillan, Eric W., Tsay, Joseph, Sides, Keith, Cairns, Jennifer, Kulitzscher, Berndt, Aldous, David J., Morize, Isabelle, Pauls, Henry W.
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Journal Article
Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P-1 ligand
Choi-Sledeski, YM, Kearney, R, Poli, G, Pauls, H, Gardner, C, Gong, Y, Becker, M, Davis, R, Spada, A, Liang, G, Chu, Brown, K, Collussi, D, Leadley, R, Rebello, S, Moxey, P, Morgan, S, Bentley, R, Kasiewski, C, Maignan, S, Guilloteau, JP, Mikol
Published in Journal of medicinal chemistry (27.02.2003)
Published in Journal of medicinal chemistry (27.02.2003)
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Journal Article
Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group
Liang, Guyan, Chen, Xin, Aldous, Suzanne, Pu, Su-Fen, Mehdi, Shujaath, Powers, Elaine, Giovanni, Andrew, Kongsamut, Sathapana, Xia, Tianhui, Zhang, Ying, Wang, Rachel, Gao, Zhongli, Merriman, Gregory, McLean, Larry R, Morize, Isabelle
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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Journal Article
Structure-based design, synthesis, and profiling of a β-tryptase inhibitor with a spiro-piperidineamide scaffold, benzylamine P1 group, and a substituted indole P4 group
Liang, Guyan, Choi-Sledeski, Yong Mi, Poli, Gregory B., Chen, Xin, Minnich, Anne, Wang, Qingping, Tsay, Joseph, Sides, Keith, Vaz, Roy J.
Published in MedChemComm (01.08.2011)
Published in MedChemComm (01.08.2011)
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Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold
Liang, Guyan, Neuenschwander, Kent, Chen, Xin, Wei, Linli, Munson, Randall, Francisco, Gerardo, Scotese, Anthony, Shutske, Gregory, Black, Mark, Sarhan, Sharkir, Jiang, Jason, Morize, Isabelle, Vaz, Roy J.
Published in MedChemComm (01.03.2011)
Published in MedChemComm (01.03.2011)
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RADIOTRACERS AND THERAPEUTICS BINDING TO FIBROBLAST ACTIVATION PROTEIN (FAP)
HAJI, Abdul, BARNES, Colin, RAHMAN, Sabitur, LIANG, Guyan, BEJOT, Romain
Year of Publication 02.03.2023
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Year of Publication 02.03.2023
Patent