SuFExable polymers with helical structures derived from thionyl tetrafluoride
Li, Suhua, Li, Gencheng, Gao, Bing, Pujari, Sidharam P., Chen, Xiaoyan, Kim, Hyunseok, Zhou, Feng, Klivansky, Liana M., Liu, Yi, Driss, Hafedh, Liang, Dong-Dong, Lu, Jianmei, Wu, Peng, Zuilhof, Han, Moses, John, Sharpless, K. Barry
Published in Nature chemistry (01.09.2021)
Published in Nature chemistry (01.09.2021)
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Journal Article
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
Liu, Zilei, Li, Jie, Li, Suhua, Li, Gencheng, Sharpless, K. Barry, Wu, Peng
Published in Journal of the American Chemical Society (28.02.2018)
Published in Journal of the American Chemical Society (28.02.2018)
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Journal Article
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery
Brighty, Gabriel J, Botham, Rachel C, Li, Suhua, Nelson, Luke, Mortenson, David E, Li, Gencheng, Morisseau, Christophe, Wang, Hua, Hammock, Bruce D, Sharpless, K Barry, Kelly, Jeffery W
Published in Nature chemistry (01.10.2020)
Published in Nature chemistry (01.10.2020)
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Journal Article
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Zheng, Qinheng, Woehl, Jordan L., Kitamura, Seiya, Santos-Martins, Diogo, Smedley, Christopher J., Li, Gencheng, Forli, Stefano, Moses, John E., Wolan, Dennis W., Sharpless, K. Barry
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.09.2019)
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Journal Article
Palladium-Catalyzed Intramolecular Asymmetric C–H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds
Deng, Ruixian, Huang, Yunze, Ma, Xinna, Li, Gencheng, Zhu, Rui, Wang, Bin, Kang, Yan-Biao, Gu, Zhenhua
Published in Journal of the American Chemical Society (26.03.2014)
Published in Journal of the American Chemical Society (26.03.2014)
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Journal Article
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.
Published in Angewandte Chemie International Edition (20.07.2020)
Published in Angewandte Chemie International Edition (20.07.2020)
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Journal Article
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
Cheng, Yunfei, Li, Gencheng, Smedley, Christopher J, Giel, Marie-Claire, Kitamura, Seiya, Woehl, Jordan L, Bianco, Giulia, Forli, Stefano, Homer, Joshua A, Cappiello, John R, Wolan, Dennis W, Moses, John E, Sharpless, K Barry
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2022)
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Journal Article
Synthesis and structure–activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents
Yang, Baiyuan, Sukheja, Paridhi, Qin, Bo, Li, Gencheng, Bare, Grant A.L., Cascioferro, Alessandro, Love, Melissa S., Petrassi, H. Michael, Sharpless, K. Barry, McNamara, Case W., Chatterjee, Arnab K.
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
Published in Bioorganic & medicinal chemistry letters (15.01.2024)
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Journal Article
Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition
McFadden, William M., Casey-Moore, Mary C., Bare, Grant A.L., Kirby, Karen A., Wen, Xin, Li, Gencheng, Wang, Hua, Slack, Ryan L., Snyder, Alexa A., Lorson, Zachary C., Kaufman, Isabella L., Cilento, Maria E., Tedbury, Philip R., Gembicky, Milan, Olson, Arthur J., Torbett, Bruce E., Sharpless, K. Barry, Sarafianos, Stefan G.
Published in Cell chemical biology (21.03.2024)
Published in Cell chemical biology (21.03.2024)
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Journal Article
Frontispiece: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.
Published in Angewandte Chemie International Edition (20.07.2020)
Published in Angewandte Chemie International Edition (20.07.2020)
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Journal Article
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.
Published in Angewandte Chemie (20.07.2020)
Published in Angewandte Chemie (20.07.2020)
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Journal Article
Frontispiz: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J, Li, Gencheng, Barrow, Andrew S, Gialelis, Timothy L, Marie‐Claire Giel, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W, Sharpless, K Barry, Moses, John E
Published in Angewandte Chemie (20.07.2020)
Published in Angewandte Chemie (20.07.2020)
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Journal Article
Frontispiz: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.
Published in Angewandte Chemie (20.07.2020)
Published in Angewandte Chemie (20.07.2020)
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Journal Article
NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF KRAS
Li, Gencheng, Qi, Chao, Carlsen, Peter, Yao, Wenqing, Hu, Bin, Yin, Haolin, Wang, Xiaozhao
Year of Publication 08.06.2023
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Year of Publication 08.06.2023
Patent
TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS
Hoang, Gia, Li, Gencheng, Li, Zhenwu, McAtee, Rory, Policarpo, Rocco, Yao, Wenqing, HU, Bin, Mukai, Ken, Susick, Robert, Wang, Xiaozhao, YU, Zhiyong, Roach, Jeremy
Year of Publication 13.04.2023
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Year of Publication 13.04.2023
Patent