Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)
Sturino, Claudio F, O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P, Chauret, Nathalie, Day, Stephen H, Lévesque, Jean-François, Seto, Carmai, Silva, Jose H, Trimble, Laird A, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M, Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A, Wang, Zhaoyin, Zamboni, Robert, Young, Robert N, Metters, Kathleen M
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Potent and highly selective DP1 antagonists with 2,3,4,9-tetrahydro-1H-carbazole as pharmacophore
LIANHAI LI, BEAULIEU, Christian, CARRIERE, Marie-Claude, DENIS, Danielle, GREIG, Gillian, GUAY, Daniel, O'NEILL, Gary, ZAMBONI, Robert, ZHAOYIN WANG
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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The identification of 4,7-disubstituted naphthoic acid derivatives as UDP-competitive antagonists of P2Y14
YVES GAUTHIER, Jacques, BELLEY, Michel, LAVALLEE, Geneviève, LEVESQUE, Jean-François, LIANHAI LI, MAMANE, Yael, MANCINI, Joseph, MORIN, Nicolas, MULROONEY, Erin, ROBICHAUD, Joel, THERIEN, Michel, TRANMER, Geoffrey, DESCHENES, Denis, ZHAOYIN WANG, JIN WU, BLACK, W. Cameron, FOURNIER, Jean-François, GAGNE, Sébastien, GAREAU, Yves, HAMEL, Martine, HENAULT, Martin, HYJAZIE, Huda, KARGMAN, Stacia
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Synthesis and SAR of pyrimidine-based, non-nucleotide P2Y₁₄ receptor antagonists
Guay, Daniel, Beaulieu, Christian, Belley, Michel, Crane, Sheldon N, DeLuca, Jeancarlo, Gareau, Yves, Hamel, Martine, Henault, Martin, Hyjazie, Huda, Kargman, Stacia, Chan, Chi Chung, Xu, Lijing, Gordon, Robert, Li, Lianhai, Mamane, Yael, Morin, Nicolas, Mancini, Joseph, Thérien, Michel, Tranmer, Geoffrey, Truong, Vouy Linh, Wang, Zhaoyin, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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Metabolic activation of indole-containing prostaglandin D2 receptor 1 antagonists: Impacts of glutathione trapping and glucuronide conjugation on covalent binding
Lévesque, Jean-François, Day, Stephen H., Chauret, Nathalie, Seto, Carmai, Trimble, Laird, Bateman, Kevin P., Silva, José M., Berthelette, Carl, Lachance, Nicolas, Boyd, Michael, Li, Lianhai, Sturino, Claudio F., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Nicoll-Griffith, Deborah A.
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
Published in Bioorganic & medicinal chemistry letters (01.06.2007)
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Identification of an indole series of prostaglandin D2 receptor antagonists
STURINO, Claudio F, LACHANCE, Nicolas, CAUCHON, Elizabeth, CARRIERE, Marie-Claude, DENIS, Danielle, GREIG, Gillian, KARGMAN, Stacia, LAMONTAGNE, Sonia, MATHIEU, Marie-Claude, SAWYER, Nicole, SLIPETZ, Deborah, O'NEILL, Gary, BOYD, Michael, ZHAOYIN WANG, ZAMBONI, Robert, METTERS, Kathleen M, YOUNG, Robert N, BERTHELETTE, Carl, LABELLE, Marc, LIANHAI LI, ROY, Bruno, SCHEIGETZ, John, TSOU, Nancy, BRIDEAU, Christine
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination
Cao, Kun, Wang, Ruonan, Li, Lianhai, Liao, Yuting, Hu, Xiao, Li, Ruixue, Liu, Xiuwen, Xiong, Xing-dong, Wang, Yanjie, Liu, Xinguang
Published in Oncogene (04.01.2024)
Published in Oncogene (04.01.2024)
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Hydrogel based on M1 macrophage lysate and alginate loading with oxaliplatin for effective immunomodulation to inhibit melanoma progression, recurrence and metastasis
Li, Wanyu, Jiang, Zhonghao, Yan, Zhuo, Chen, Zhihao, Li, Lianhai, Wang, Dan, Wang, Jilong, Li, Li, Yang, Huiling, Deng, Junjie, Lin, Jiantao
Published in International journal of biological macromolecules (01.11.2024)
Published in International journal of biological macromolecules (01.11.2024)
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Discovery of a potent and selective prostaglandin D-2 receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524)
Sturino, Claudio F., O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P., Chauret, Nathalie, Day, Stephen H., Levesque, Jean-Francois, Seto, Carmai, Silva, Jose H., Trimble, Laird A., Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M., Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Metters, Kathleen M.
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid
Li, Lianhai, Mathieu, Marie-Claude, Denis, Danielle, Therien, Alex G, Wang, Zhaoyin
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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The identification of substituted benzothiophene derivatives as PGE 2 subtype 4 receptor antagonists: From acid to non-acid
Li, Lianhai, Mathieu, Marie-Claude, Denis, Danielle, Therien, Alex G., Wang, Zhaoyin
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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Derivatives of Mesoxalic Acid Block Translocation of HIV-1 Reverse Transcriptase
Bernatchez, Jean A., Paul, Rakesh, Tchesnokov, Egor P., Ngure, Marianne, Beilhartz, Greg L., Berghuis, Albert M., Lavoie, Rico, Li, Lianhai, Auger, Anick, Melnyk, Roman A., Grobler, Jay A., Miller, Michael D., Hazuda, Daria J., Hecht, Sidney M., Götte, Matthias
Published in The Journal of biological chemistry (16.01.2015)
Published in The Journal of biological chemistry (16.01.2015)
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