Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
Black, W. Cameron, Bayly, Christopher I., Davis, Dana E., Desmarais, Sylvie, Falgueyret, Jean-Pierre, Léger, Serge, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Palmer, James T., Percival, M. David, Robichaud, Joël, Tsou, Nancy, Zamboni, Robert
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)
Léger, Serge, Black, W. Cameron, Deschenes, Denis, Dolman, Sarah, Falgueyret, Jean-Pierre, Gagnon, Marc, Guiral, Sébastien, Huang, Zheng, Guay, Jocelyne, Leblanc, Yves, Li, Chun-Sing, Massé, Frédéric, Oballa, Renata, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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Journal Article
Thiazole analog as stearoyl-CoA desaturase 1 inhibitor
Li, Chun Sing, Belair, Liette, Guay, Jocelyne, Murgasva, Renata, Sturkenboom, Wayne, Ramtohul, Yeeman K., Zhang, Lei, Huang, Zheng
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives
Li, Chun-Sing, Black, W. Cameron, Chan, Chi-Chung, Ford-Hutchinson, Anthony W, Gauthier, Jacques-Yves, Gordon, Robert, Guay, Daniel, Kargman, Stacia, Lau, Cheuk K
Published in Journal of medicinal chemistry (01.12.1995)
Published in Journal of medicinal chemistry (01.12.1995)
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Journal Article
SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors
Ramtohul, Yeeman K., Black, Cameron, Chan, Chi-Chung, Crane, Sheldon, Guay, Jocelyne, Guiral, Sébastien, Huang, Zheng, Oballa, Renata, Xu, Li-Jing, Zhang, Lei, Li, Chun Sing
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
The identification of potent, selective, and bioavailable cathepsin S inhibitors
Gauthier, Jacques Yves, Black, W. Cameron, Courchesne, Isabelle, Cromlish, Wanda, Desmarais, Sylvie, Houle, Robert, Lamontagne, Sonia, Li, Chun Sing, Massé, Frédéric, McKay, Daniel J., Ouellet, Marc, Robichaud, Joël, Truchon, Jean-François, Truong, Vouy-Linh, Wang, Qingping, Percival, M. David
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Journal Article
Plasma-based approach to measure target engagement for liver-targeting stearoyl-CoA desaturase 1 inhibitors
Landry, France, Chan, Chi-Chung, Huang, Zheng, Leclair, Gregoire, Li, Chun Sing, Oballa, Renata, Zhang, Lei, Bateman, Kevin
Published in Journal of lipid research (01.08.2011)
Published in Journal of lipid research (01.08.2011)
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Journal Article
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors
Ramtohul, Yeeman K., Powell, David, Leclerc, Jean-Philippe, Leger, Serge, Oballa, Renata, Black, Cameron, Isabel, Elise, Li, Chun Sing, Crane, Sheldon, Robichaud, Joel, Guay, Jocelyne, Guiral, Sébastien, Zhang, Lei, Huang, Zheng
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
Published in Bioorganic & medicinal chemistry letters (01.10.2011)
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Journal Article
Identification of a potent and selective non-basic cathepsin K inhibitor
Li, Chun Sing, Deschenes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Kimmel, Donald. B., Léger, Serge, Massé, Frédéric, McGrath, Mary E., McKay, Daniel J., Percival, M. David, Riendeau, Denis, Rodan, Sevgi B., Thérien, Michel, Truong, Vouy-Linh, Wesolowski, Gregg, Zamboni, Robert, Black, W. Cameron
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors
Leclerc, Jean-Philippe, Falgueyret, Jean-Pierre, Girardin, Mélina, Guay, Jocelyne, Guiral, Sébastien, Huang, Zheng, Li, Chun Sing, Oballa, Renata, Ramtohul, Yeeman K., Skorey, Kathryn, Tawa, Paul, Wang, Hao, Zhang, Lei
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Journal Article
Difluoroethylamines as an amide isostere in inhibitors of cathepsin K
Isabel, Elise, Mellon, Christophe, Boyd, Michael J., Chauret, Nathalie, Deschênes, Denis, Desmarais, Sylvie, Falgueyret, Jean-Pierre, Gauthier, Jacques Yves, Khougaz, Karine, Lau, Cheuk K., Léger, Serge, Levorse, Dorothy A., Li, Chun Sing, Massé, Frédéric, David Percival, M., Roy, Bruno, Scheigetz, John, Thérien, Michel, Truong, Vouy Linh, Wesolowski, Gregg, Young, Robert N., Zamboni, Robert, Cameron Black, W.
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
Published in Bioorganic & medicinal chemistry letters (01.02.2011)
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Journal Article
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
LOU, Cheuk K, BAYLY, Christopher I, QINGPING WANG, SKOREY, Kathryn, WADDLETON, Deena, PAYETTE, Paul, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, SCAPIN, Giovana, GAUTHIER, Jacques Yves, CHUN SING LI, THERIEN, Michel, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Journal Article
Pyridazinones as selective cyclooxygenase-2 inhibitors
Li, Chun Sing, Brideau, Christine, Chan, Chi Chung, Savoie, Chantal, Claveau, David, Charleson, Stella, Gordon, Robert, Greig, Gillian, Gauthier, Jacques Yves, Lau, Cheuk K, Riendeau, Denis, Thérien, Michel, Wong, Elizabeth, Prasit, Petpiboon
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Journal Article
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility
Black, W.Cameron, Brideau, Christine, Chan, Chi-Chung, Charleson, Stella, Cromlish, Wanda, Gordon, Robert, Grimm, Erich L., Hughes, Gregory, Leger, Serge, Li, Chun-Sing, Riendeau, Denis, Thérien, Michel, Wang, Zhaoyin, Xu, Li-Jing, Prasit, Petpiboon
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Journal Article
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2
RIENDEAU, Denis, SALEM, Myriam, STYHLER, Angela, OUELLET, Marc, MANCINI, Joseph A, CHUN SING LI
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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