Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
Shaw, Alice T, Winslow, Monte M, Magendantz, Margaret, Ouyang, Chensi, Dowdle, James, Subramanian, Aravind, Lewis, Timothy A, Maglathin, Rebecca L, Tolliday, Nicola, Jacks, Tyler
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2011)
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Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells
Lopez-Sambrooks, Cecilia, Shrimal, Shiteshu, Khodier, Carol, Flaherty, Daniel P, Rinis, Natalie, Charest, Jonathan C, Gao, Ningguo, Zhao, Peng, Wells, Lance, Lewis, Timothy A, Lehrman, Mark A, Gilmore, Reid, Golden, Jennifer E, Contessa, Joseph N
Published in Nature chemical biology (01.12.2016)
Published in Nature chemical biology (01.12.2016)
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NIAID workshop on T cell technologies
Gondré-Lewis, Timothy A., Jiang, Chao, Ford, Mandy L., Koelle, David M., Sette, Alessandro, Shalek, Alex K., Thomas, Paul G.
Published in Nature immunology (01.01.2023)
Published in Nature immunology (01.01.2023)
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Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
Hu, Longqin, Magesh, Sadagopan, Chen, Lin, Wang, Lili, Lewis, Timothy A., Chen, Yu, Khodier, Carol, Inoyama, Daigo, Beamer, Lesa J., Emge, Thomas J., Shen, Jian, Kerrigan, John E., Kong, Ah-Ng Tony, Dandapani, Sivaraman, Palmer, Michelle, Schreiber, Stuart L., Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL
Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben
Published in Cancer cell (13.09.2011)
Published in Cancer cell (13.09.2011)
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Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity
Schuetz, Anja, Min, Jinrong, Allali-Hassani, Abdellah, Schapira, Matthieu, Shuen, Michael, Loppnau, Peter, Mazitschek, Ralph, Kwiatkowski, Nick P., Lewis, Timothy A., Maglathin, Rebecca L., McLean, Thomas H., Bochkarev, Alexey, Plotnikov, Alexander N., Vedadi, Masoud, Arrowsmith, Cheryl H.
Published in The Journal of biological chemistry (25.04.2008)
Published in The Journal of biological chemistry (25.04.2008)
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Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Golub, Todd R, Du, Jinyan, Bernasconi, Paula, Clauser, Karl R, Mani, D R, Finn, Stephen P, Beroukhim, Rameen, Burns, Melissa, Julian, Bina, Peng, Xiao P, Hieronymus, Haley, Maglathlin, Rebecca L, Lewis, Timothy A, Liau, Linda M, Nghiemphu, Phioanh, Mellinghoff, Ingo K, Louis, David N, Loda, Massimo, Carr, Steven A, Kung, Andrew L
Published in Nature biotechnology (01.01.2009)
Published in Nature biotechnology (01.01.2009)
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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway
Nakasone, Mark A., Lewis, Timothy A., Walker, Olivier, Thakur, Anita, Mansour, Wissam, Castañeda, Carlos A., Goeckeler-Fried, Jennifer L., Parlati, Frank, Chou, Tsui-Fen, Hayat, Ortal, Zhang, Daoning, Camara, Christina M., Bonn, Steven M., Nowicka, Urszula K., Krueger, Susan, Glickman, Michael H., Brodsky, Jeffrey L., Deshaies, Raymond J., Fushman, David
Published in Structure (London) (05.12.2017)
Published in Structure (London) (05.12.2017)
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Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation
Zhang, Zhengjian, Boskovic, Zarko, Hussain, Mahmud M, Hu, Wenxin, Inouye, Carla, Kim, Han-Je, Abole, A Katherine, Doud, Mary K, Lewis, Timothy A, Koehler, Angela N, Schreiber, Stuart L, Tjian, Robert
Published in eLife (28.08.2015)
Published in eLife (28.08.2015)
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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
Kubicek, Stefan, Gilbert, Joshua C, Fomina-Yadlin, Dina, Gitlin, Alexander D, Yuan, Yuan, Wagner, Florence F, Holson, Edward B, Luo, Tuoping, Lewis, Timothy A, Taylor, Bradley, Gupta, Supriya, Shamji, Alykhan F, Wagner, Bridget K, Clemons, Paul A, Schreiber, Stuart L
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (03.04.2012)
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Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sarkar, Sovan, Perlstein, Ethan O, Imarisio, Sara, Pineau, Sandra, Cordenier, Axelle, Maglathlin, Rebecca L, Webster, John A, Lewis, Timothy A, O'Kane, Cahir J, Schreiber, Stuart L, Rubinsztein, David C
Published in Nature chemical biology (07.05.2007)
Published in Nature chemical biology (07.05.2007)
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Roscovitine Inhibits EBNA1 Serine 393 Phosphorylation, Nuclear Localization, Transcription, and Episome Maintenance
KANG, Myung-Soo, EUN KYUNG LEE, SONI, Vishal, LEWIS, Timothy A, KOEHLER, Angela N, SRINIVASAN, Viswanathan, KIEFF, Elliott
Published in Journal of Virology (15.03.2011)
Published in Journal of Virology (15.03.2011)
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Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin
Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J
Published in ACS medicinal chemistry letters (13.01.2011)
Published in ACS medicinal chemistry letters (13.01.2011)
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Hematopoietic cell types: Prototype for a revised cell ontology
Diehl, Alexander D., Augustine, Alison Deckhut, Blake, Judith A., Cowell, Lindsay G., Gold, Elizabeth S., Gondré-Lewis, Timothy A., Masci, Anna Maria, Meehan, Terrence F., Morel, Penelope A., Nijnik, Anastasia, Peters, Bjoern, Pulendran, Bali, Scheuermann, Richard H., Yao, Q. Alison, Zand, Martin S., Mungall, Christopher J.
Published in Journal of biomedical informatics (01.02.2011)
Published in Journal of biomedical informatics (01.02.2011)
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Identification of a selective small molecule inhibitor of breast cancer stem cells
Germain, Andrew R., Carmody, Leigh C., Morgan, Barbara, Fernandez, Cristina, Forbeck, Erin, Lewis, Timothy A., Nag, Partha P., Ting, Amal, VerPlank, Lynn, Feng, Yuxiong, Perez, Jose R., Dandapani, Sivaraman, Palmer, Michelle, Lander, Eric S., Gupta, Piyush B., Schreiber, Stuart L., Munoz, Benito
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
Published in Bioorganic & medicinal chemistry letters (15.05.2012)
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Small molecules, big players : the national cancer institute's initiative for chemical genetics
TOLLIDAY, Nicola, CLEMONS, Paul A, FERRAIOLO, Paul, KOEHLER, Angela N, LEWIS, Timothy A, XIAOHUA LI, SCHREIBER, Stuart L, GERHARD, Daniela S, ELIASOF, Scott
Published in Cancer research (Chicago, Ill.) (15.09.2006)
Published in Cancer research (Chicago, Ill.) (15.09.2006)
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Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies
Dockendorff, Chris, Nagiec, Marek M, Weïwer, Michel, Buhrlage, Sara, Ting, Amal, Nag, Partha P, Germain, Andrew, Kim, Han-Je, Youngsaye, Willmen, Scherer, Christina, Bennion, Melissa, Xue, Linlong, Stanton, Benjamin Z, Lewis, Timothy A, MacPherson, Lawrence, Palmer, Michelle, Foley, Michael A, Perez, José R, Schreiber, Stuart L
Published in ACS medicinal chemistry letters (11.10.2012)
Published in ACS medicinal chemistry letters (11.10.2012)
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Molecular Engineering of Stabilized Silicon-Rosindolizine Shortwave Infrared Fluorophores
Meador, William E., Lewis, Timothy A., Shaik, Abdul K., Wijesinghe, Kalpani Hirunika, Yang, Boqian, Dass, Amala, Hammer, Nathan I., Delcamp, Jared H.
Published in Journal of organic chemistry (01.03.2024)
Published in Journal of organic chemistry (01.03.2024)
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