Identification of potent and selective MTH1 inhibitors
Petrocchi, Alessia, Leo, Elisabetta, Reyna, Naphtali J., Hamilton, Matthew M., Shi, Xi, Parker, Connor A., Mseeh, Faika, Bardenhagen, Jennifer P., Leonard, Paul, Cross, Jason B., Huang, Sha, Jiang, Yongying, Cardozo, Mario, Draetta, Giulio, Marszalek, Joseph R., Toniatti, Carlo, Jones, Philip, Lewis, Richard T.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Imidazo[1,2-a]pyrimidines as Functionally Selective and Orally Bioavailable GABAAα2/α3 Binding Site Agonists for the Treatment of Anxiety Disorders
Goodacre, Simon C, Street, Leslie J, Hallett, David J, Crawforth, James M, Kelly, Sarah, Owens, Andrew P, Blackaby, Wesley P, Lewis, Richard T, Stanley, Joanna, Smith, Alison J, Ferris, Pushpinder, Sohal, Bindi, Cook, Susan M, Pike, Andrew, Brown, Nicola, Wafford, Keith A, Marshall, George, Castro, José L, Atack, John R
Published in Journal of medicinal chemistry (12.01.2006)
Published in Journal of medicinal chemistry (12.01.2006)
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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T
Published in Journal of medicinal chemistry (12.08.2021)
Published in Journal of medicinal chemistry (12.08.2021)
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Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1
Blackaby, Wesley P, Lewis, Richard T, Thomson, Joanne L, Jennings, Andrew S. R, Goodacre, Simon C, Street, Leslie J, MacLeod, Angus M, Pike, Andrew, Wood, Suzanne, Thomas, Steve, Brown, Terry A, Smith, Alison, Pillai, Gopalan, Almond, Sarah, Guscott, Martin R, Burns, H. Donald, Eng, Waisi, Ryan, Christine, Cook, Jacquelynn, Hamill, Terence G
Published in ACS medicinal chemistry letters (14.10.2010)
Published in ACS medicinal chemistry letters (14.10.2010)
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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors
Bregman, Howard, Simard, Jeffrey R, Andrews, Kristin L, Ayube, Shawn, Chen, Hao, Gunaydin, Hakan, Guzman-Perez, Angel, Hu, Jiali, Huang, Liyue, Huang, Xin, Krolikowski, Paul H, Lehto, Sonya G, Lewis, Richard T, Michelsen, Klaus, Pegman, Pamela, Plant, Matthew H, Shaffer, Paul L, Teffera, Yohannes, Yi, Shuyan, Zhang, Maosheng, Gingras, Jacinthe, DiMauro, Erin F
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer
Lewis, Richard T, Bode, Christiane M, Choquette, Deborah M, Potashman, Michele, Romero, Karina, Stellwagen, John C, Teffera, Yohannes, Moore, Earl, Whittington, Douglas A, Chen, Hao, Epstein, Linda F, Emkey, Renee, Andrews, Paul S, Yu, Violeta L, Saffran, Douglas C, Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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Journal Article
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling
Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.
Published in Bioorganic & medicinal chemistry (15.05.2016)
Published in Bioorganic & medicinal chemistry (15.05.2016)
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Journal Article
Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors
Bryan, Marian C, Whittington, Douglas A, Doherty, Elizabeth M, Falsey, James R, Cheng, Alan C, Emkey, Renee, Brake, Rachael L, Lewis, Richard T
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Corrigendum to “Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling” [Bioorg. Med. Chem. 24 (2016) 2215–2234]
Liu, Longbin, Lee, Matthew R., Kim, Joseph L., Whittington, Douglas A., Bregman, Howard, Hua, Zihao, Lewis, Richard T., Martin, Matthew W., Nishimura, Nobuko, Potashman, Michele, Yang, Kevin, Yi, Shuyan, Vaida, Karina R., Epstein, Linda F., Babij, Carol, Fernando, Manory, Carnahan, Josette, Norman, Mark H.
Published in Bioorganic & medicinal chemistry (01.07.2016)
Published in Bioorganic & medicinal chemistry (01.07.2016)
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Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors
Peterson, Emily A., Boezio, Alessandro A., Andrews, Paul S., Boezio, Christiane M., Bush, Tammy L., Cheng, Alan C., Choquette, Deborah, Coats, James R., Colletti, Adria E., Copeland, Katrina W., DuPont, Michelle, Graceffa, Russell, Grubinska, Barbara, Kim, Joseph L., Lewis, Richard T., Liu, Jingzhou, Mullady, Erin L., Potashman, Michele H., Romero, Karina, Shaffer, Paul L., Stanton, Mary K., Stellwagen, John C., Teffera, Yohannes, Yi, Shuyan, Cai, Ti, La, Daniel S.
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
Published in Bioorganic & medicinal chemistry letters (01.08.2012)
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Journal Article
Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors
Teffera, Yohannes, Berry, Loren M, Brake, Rachael L, Lewis, Richard T, Saffran, Douglas C, Moore, Earl, Liu, Jingzhou, Zhao, Zhiyang
Published in Drug metabolism and disposition (01.01.2013)
Published in Drug metabolism and disposition (01.01.2013)
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Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors
Bode, Christiane M., Boezio, Alessandro A., Albrecht, Brian K., Bellon, Steven F., Berry, Loren, Broome, Martin A., Choquette, Deborah, Dussault, Isabelle, Lewis, Richard T., Lin, Min-Hwa Jasmine, Rex, Karen, Whittington, Douglas A., Yang, Yajing, Harmange, Jean-Christophe
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
Published in Bioorganic & medicinal chemistry letters (15.06.2012)
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Tryptophan-Derived NK1 Antagonists: Conformationally Constrained Heterocyclic Bioisosteres of the Ester Linkage
Lewis, Richard T, Macleod, Angus M, Merchant, Kevin J, Kelleher, Fintan, Sanderson, Ian, Herbert, Richard H, Cascieri, Margaret A, Sadowski, Sharon, Ball, Richard G, Hoogsteen, Karst
Published in Journal of medicinal chemistry (01.03.1995)
Published in Journal of medicinal chemistry (01.03.1995)
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Optimisation of a series of potent, selective and orally bioavailable GlyT1 inhibitors
Thomson, Joanne L., Blackaby, Wesley P., Jennings, Andrew S.R., Goodacre, Simon C., Pike, Andrew, Thomas, Steve, Brown, Terry A., Smith, Alison, Pillai, Gopalan, Street, Leslie J., Lewis, Richard T.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Journal Article
Imidazo[1,2 -a]pyrimidines as functionally selective GABAA ligands
BLACKABY, Wesley P, ATACK, John R, STREET, Leslie J, TATTERSALL, David F. D, WAFFORD, Keith A, BROMIDGE, Frances, CASTRO, José L, GOODACRE, Simon C, HALLETT, David J, LEWIS, Richard T, MARSHALL, George R, PIKE, Andrew, SMITH, Alison J
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Imidazo[1,2- a]pyrimidines as functionally selective GABA A ligands
Blackaby, Wesley P., Atack, John R., Bromidge, Frances, Castro, José L., Goodacre, Simon C., Hallett, David J., Lewis, Richard T., Marshall, George R., Pike, Andrew, Smith, Alison J., Street, Leslie J., Tattersall, David F.D., Wafford, Keith A.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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The in vivo properties of pagoclone in rat are most likely mediated by 5′-hydroxy pagoclone
Atack, John R., Pike, Andy, Marshall, George, Stanley, Jo, Lincoln, Rachael, Cook, Susan M., Lewis, Richard T., Blackaby, Wesley P., Goodacre, Simon C., McKernan, Ruth M., Dawson, Gerard R., Wafford, Keith A., Reynolds, David S.
Published in Neuropharmacology (01.05.2006)
Published in Neuropharmacology (01.05.2006)
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Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety
Jennings, Andrew S.R., Lewis, Richard T., Russell, Michael G.N., Hallett, David J., Street, Leslie J., Castro, José L., Atack, John R., Cook, Susan M., Lincoln, Rachael, Stanley, Joanna, Smith, Alison J., Reynolds, David S., Sohal, Bindi, Pike, Andrew, Marshall, George R., Wafford, Keith A., Sheppard, Wayne F.A., Tye, Spencer J.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
Published in Bioorganic & medicinal chemistry letters (15.03.2006)
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Synthesis of a remarkably stable bicyclo[7.3.1]diynene esperamicin A1/calicheamicin .gamma. system. Structural requirements for facile formation of a 1,4-diyl
Magnus, Philip, Lewis, Richard T, Huffman, John C
Published in Journal of the American Chemical Society (01.09.1988)
Published in Journal of the American Chemical Society (01.09.1988)
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RIP Kinase 1 (RIPK1) modulates disease associated microglial response during demyelination
Goodwani, Sunil, Lightfoot, Yaima Luzardo, Ford, Bianca Gabrielle, Calderon, Olivia, McReynolds, Morgan, Allton, Kendra, Ma, Jiacheng, Botte, Alexandra, Trinh, Ronnie The Pong, Pearson, Troy, Ding, Grant S., Acton, Paul, Lewis, Richard T, Ray, William J
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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