KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors
Black, Joshua C., Manning, Amity L., Van Rechem, Capucine, Kim, Jaegil, Ladd, Brendon, Cho, Juok, Pineda, Cristiana M., Murphy, Nancy, Daniels, Danette L., Montagna, Cristina, Lewis, Peter W., Glass, Kimberly, Allis, C. David, Dyson, Nicholas J., Getz, Gad, Whetstine, Johnathan R.
Published in Cell (01.08.2013)
Published in Cell (01.08.2013)
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Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Lewis, Peter W., Müller, Manuel M., Koletsky, Matthew S., Cordero, Francisco, Lin, Shu, Banaszynski, Laura A., Garcia, Benjamin A., Muir, Tom W., Becher, Oren J., Allis, C. David
Published in Science (American Association for the Advancement of Science) (17.05.2013)
Published in Science (American Association for the Advancement of Science) (17.05.2013)
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PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism
Jain, Siddhant U., Do, Truman J., Lund, Peder J., Rashoff, Andrew Q., Diehl, Katharine L., Cieslik, Marcin, Bajic, Andrea, Juretic, Nikoleta, Deshmukh, Shriya, Venneti, Sriram, Muir, Tom W., Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Published in Nature communications (13.05.2019)
Published in Nature communications (13.05.2019)
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Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
Lewis, Peter W., Elsaesser, Simon J., Noh, Kyung-Min, Stadler, Sonja C., Allis, C. David
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2010)
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ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
Chan, Chang S., Laddha, Saurabh V., Lewis, Peter W., Koletsky, Matthew S., Robzyk, Kenneth, Da Silva, Edaise, Torres, Paula J., Untch, Brian R., Li, Janet, Bose, Promita, Chan, Timothy A., Klimstra, David S., Allis, C. David, Tang, Laura H.
Published in Nature communications (12.10.2018)
Published in Nature communications (12.10.2018)
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Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation
McDaniel, Stephen L., Gibson, Tyler J., Schulz, Katharine N., Fernandez Garcia, Meilin, Nevil, Markus, Jain, Siddhant U., Lewis, Peter W., Zaret, Kenneth S., Harrison, Melissa M.
Published in Molecular cell (04.04.2019)
Published in Molecular cell (04.04.2019)
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Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
Papillon-Cavanagh, Simon, Lu, Chao, Gayden, Tenzin, Mikael, Leonie G, Bechet, Denise, Karamboulas, Christina, Ailles, Laurie, Karamchandani, Jason, Marchione, Dylan M, Garcia, Benjamin A, Weinreb, Ilan, Goldstein, David, Lewis, Peter W, Dancu, Octavia Maria, Dhaliwal, Sandeep, Stecho, William, Howlett, Christopher J, Mymryk, Joe S, Barrett, John W, Nichols, Anthony C, Allis, C David, Majewski, Jacek, Jabado, Nada
Published in Nature genetics (01.02.2017)
Published in Nature genetics (01.02.2017)
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Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Lu, Chao, Jain, Siddhant U., Hoelper, Dominik, Bechet, Denise, Molden, Rosalynn C., Ran, Leili, Murphy, Devan, Venneti, Sriram, Hameed, Meera, Pawel, Bruce R., Wunder, Jay S., Dickson, Brendan C., Lundgren, Stefan M., Jani, Krupa S., De Jay, Nicolas, Papillon-Cavanagh, Simon, Andrulis, Irene L., Sawyer, Sarah L., Grynspan, David, Turcotte, Robert E., Nadaf, Javad, Fahiminiyah, Somayyeh, Muir, Tom W., Majewski, Jacek, Thompson, Craig B., Chi, Ping, Garcia, Benjamin A., Allis, C. David, Jabado, Nada, Lewis, Peter W.
Published in Science (American Association for the Advancement of Science) (13.05.2016)
Published in Science (American Association for the Advancement of Science) (13.05.2016)
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Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression
Jain, Siddhant U., Khazaei, Sima, Marchione, Dylan M., Lundgren, Stefan M., Wang, Xiaoshi, Weinberg, Daniel N., Deshmukh, Shriya, Juretic, Nikoleta, Lu, Chao, Allis, C. David, Garcia, Benjamin A., Jabado, Nada, Lewis, Peter W.
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (03.11.2020)
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Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase
Jani, Krupa S., Jain, Siddhant U., Ge, Eva J., Diehl, Katharine L., Lundgren, Stefan M., Müller, Manuel M., Lewis, Peter W., Muir, Tom W.
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2019)
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas
Bayliss, Jill, Mukherjee, Piali, Lu, Chao, Jain, Siddhant U, Chung, Chan, Martinez, Daniel, Sabari, Benjamin, Margol, Ashley S, Panwalkar, Pooja, Parolia, Abhijit, Pekmezci, Melike, McEachin, Richard C, Cieslik, Marcin, Tamrazi, Benita, Garcia, Benjamin A, La Rocca, Gaspare, Santi, Mariarita, Lewis, Peter W, Hawkins, Cynthia, Melnick, Ari, David Allis, C, Thompson, Craig B, Chinnaiyan, Arul M, Judkins, Alexander R, Venneti, Sriram
Published in Science translational medicine (23.11.2016)
Published in Science translational medicine (23.11.2016)
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Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Goldberg, Aaron D., Banaszynski, Laura A., Noh, Kyung-Min, Lewis, Peter W., Elsaesser, Simon J., Stadler, Sonja, Dewell, Scott, Law, Martin, Guo, Xingyi, Li, Xuan, Wen, Duancheng, Chapgier, Ariane, DeKelver, Russell C., Miller, Jeffrey C., Lee, Ya-Li, Boydston, Elizabeth A., Holmes, Michael C., Gregory, Philip D., Greally, John M., Rafii, Shahin, Yang, Chingwen, Scambler, Peter J., Garrick, David, Gibbons, Richard J., Higgs, Douglas R., Cristea, Ileana M., Urnov, Fyodor D., Zheng, Deyou, Allis, C. David
Published in Cell (05.03.2010)
Published in Cell (05.03.2010)
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ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome
Patel, Dinshaw J, Li, Haitao, Shi, Yang, Iwase, Shigeki, Xiang, Bin, Ghosh, Sharmistha, Ren, Ting, Lewis, Peter W, Cochrane, Jesse C, Allis, C David, Picketts, David J
Published in Nature structural & molecular biology (01.07.2011)
Published in Nature structural & molecular biology (01.07.2011)
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A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas
Venneti, Sriram, Santi, Mariarita, Felicella, Michelle Madden, Yarilin, Dmitry, Phillips, Joanna J., Sullivan, Lisa M., Martinez, Daniel, Perry, Arie, Lewis, Peter W., Thompson, Craig B., Judkins, Alexander R.
Published in Acta neuropathologica (01.11.2014)
Published in Acta neuropathologica (01.11.2014)
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Khazaei, Sima, De Jay, Nicolas, Deshmukh, Shriya, Hendrikse, Liam D, Jawhar, Wajih, Chen, Carol C L, Mikael, Leonie G, Faury, Damien, Marchione, Dylan M, Lanoix, Joel, Bonneil, Éric, Ishii, Takeaki, Jain, Siddhant U, Rossokhata, Kateryna, Sihota, Tianna S, Eveleigh, Robert, Lisi, Véronique, Harutyunyan, Ashot S, Jung, Sungmi, Karamchandani, Jason, Dickson, Brendan C, Turcotte, Robert, Wunder, Jay S, Thibault, Pierre, Lewis, Peter W, Garcia, Benjamin A, Mack, Stephen C, Taylor, Michael D, Garzia, Livia, Kleinman, Claudia L, Jabado, Nada
Published in Cancer discovery (01.12.2020)
Published in Cancer discovery (01.12.2020)
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