Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Fang, Mark Y., Markmiller, Sebastian, Vu, Anthony Q., Javaherian, Ashkan, Dowdle, William E., Jolivet, Philippe, Bushway, Paul J., Castello, Nicholas A., Baral, Ashmita, Chan, Michelle Y., Linsley, Jeremy W., Linsley, Drew, Mercola, Mark, Finkbeiner, Steven, Lecuyer, Eric, Lewcock, Joseph W., Yeo, Gene W.
Published in Neuron (Cambridge, Mass.) (04.09.2019)
Published in Neuron (Cambridge, Mass.) (04.09.2019)
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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury
Watkins, Trent A., Wang, Bei, Huntwork-Rodriguez, Sarah, Yang, Jing, Jiang, Zhiyu, Eastham-Anderson, Jeffrey, Modrusan, Zora, Kaminker, Joshua S., Tessier-Lavigne, Marc, Lewcock, Joseph W.
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (05.03.2013)
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Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
Schlepckow, Kai, Monroe, Kathryn M, Kleinberger, Gernot, Cantuti‐Castelvetri, Ludovico, Parhizkar, Samira, Xia, Dan, Willem, Michael, Werner, Georg, Pettkus, Nadine, Brunner, Bettina, Sülzen, Alice, Nuscher, Brigitte, Hampel, Heike, Xiang, Xianyuan, Feederle, Regina, Tahirovic, Sabina, Park, Joshua I, Prorok, Rachel, Mahon, Cathal, Liang, Chun‐Chi, Shi, Ju, Kim, Do Jin, Sabelström, Hanna, Huang, Fen, Di Paolo, Gilbert, Simons, Mikael, Lewcock, Joseph W, Haass, Christian
Published in EMBO molecular medicine (07.04.2020)
Published in EMBO molecular medicine (07.04.2020)
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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
Huntwork-Rodriguez, Sarah, Wang, Bei, Watkins, Trent, Ghosh, Arundhati Sengupta, Pozniak, Christine D, Bustos, Daisy, Newton, Kim, Kirkpatrick, Donald S, Lewcock, Joseph W
Published in The Journal of cell biology (02.09.2013)
Published in The Journal of cell biology (02.09.2013)
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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
Le Pichon, Claire E, Meilandt, William J, Dominguez, Sara, Solanoy, Hilda, Lin, Han, Ngu, Hai, Gogineni, Alvin, Sengupta Ghosh, Arundhati, Jiang, Zhiyu, Lee, Seung-Hye, Maloney, Janice, Gandham, Vineela D, Pozniak, Christine D, Wang, Bei, Lee, Sebum, Siu, Michael, Patel, Snahel, Modrusan, Zora, Liu, Xingrong, Rudhard, York, Baca, Miriam, Gustafson, Amy, Kaminker, Josh, Carano, Richard A D, Huang, Eric J, Foreman, Oded, Weimer, Robby, Scearce-Levie, Kimberly, Lewcock, Joseph W
Published in Science translational medicine (16.08.2017)
Published in Science translational medicine (16.08.2017)
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C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice
Lobsiger, Christian S, Boillée, Severine, Pozniak, Christine, Khan, Amir M, McAlonis-Downes, Melissa, Lewcock, Joseph W, Cleveland, Don W
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (12.11.2013)
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Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
Pozniak, Christine D, Sengupta Ghosh, Arundhati, Gogineni, Alvin, Hanson, Jesse E, Lee, Seung-Hye, Larson, Jessica L, Solanoy, Hilda, Bustos, Daisy, Li, Hong, Ngu, Hai, Jubb, Adrian M, Ayalon, Gai, Wu, Jiansheng, Scearce-Levie, Kimberly, Zhou, Qiang, Weimer, Robby M, Kirkpatrick, Donald S, Lewcock, Joseph W
Published in The Journal of experimental medicine (18.11.2013)
Published in The Journal of experimental medicine (18.11.2013)
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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes
Wang, Xiang, Bondar, Vitaliy V, Davis, Oliver B, Maloney, Michael T, Agam, Maayan, Chin, Marcus Y, Cheuk-Nga Ho, Audrey, Ghosh, Rajarshi, Leto, Dara E, Joy, David, Calvert, Meredith E K, Lewcock, Joseph W, Di Paolo, Gilbert, Thorne, Robert G, Sweeney, Zachary K, Henry, Anastasia G
Published in eLife (24.10.2023)
Published in eLife (24.10.2023)
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
Larhammar, Martin, Huntwork-Rodriguez, Sarah, Jiang, Zhiyu, Solanoy, Hilda, Sengupta Ghosh, Arundhati, Wang, Bei, Kaminker, Joshua S, Huang, Kevin, Eastham-Anderson, Jeffrey, Siu, Michael, Modrusan, Zora, Farley, Madeline M, Tessier-Lavigne, Marc, Lewcock, Joseph W, Watkins, Trent A
Published in eLife (25.04.2017)
Published in eLife (25.04.2017)
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A Feedback Mechanism Regulates Monoallelic Odorant Receptor Expression
Lewcock, Joseph W., Reed, Randall R.
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (27.01.2004)
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Cell Death and Neurodegeneration
Andreone, Benjamin J, Larhammar, Martin, Lewcock, Joseph W
Published in Cold Spring Harbor perspectives in biology (01.02.2020)
Published in Cold Spring Harbor perspectives in biology (01.02.2020)
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Leveraging preclinical models for the development of Alzheimer disease therapeutics
Scearce-Levie, Kimberly, Sanchez, Pascal E, Lewcock, Joseph W
Published in Nature reviews. Drug discovery (01.07.2020)
Published in Nature reviews. Drug discovery (01.07.2020)
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Spatially coordinated kinase signaling regulates local axon degeneration
Chen, Mark, Maloney, Janice A, Kallop, Dara Y, Atwal, Jasvinder K, Tam, Stephen J, Baer, Kristin, Kissel, Holger, Kaminker, Joshua S, Lewcock, Joseph W, Weimer, Robby M, Watts, Ryan J
Published in The Journal of neuroscience (26.09.2012)
Published in The Journal of neuroscience (26.09.2012)
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Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6
Heise, Christopher E, Murray, Jeremy, Augustyn, Katherine E, Bravo, Brandon, Chugha, Preeti, Cohen, Frederick, Giannetti, Anthony M, Gibbons, Paul, Hannoush, Rami N, Hearn, Brian R, Jaishankar, Priyadarshini, Ly, Cuong Q, Shah, Kinjalkumar, Stanger, Karen, Steffek, Micah, Tang, Yinyan, Zhao, Xianrui, Lewcock, Joseph W, Renslo, Adam R, Flygare, John, Arkin, Michelle R
Published in PloS one (05.12.2012)
Published in PloS one (05.12.2012)
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Cholinergic Input Is Required during Embryonic Development to Mediate Proper Assembly of Spinal Locomotor Circuits
Myers, Christopher P., Lewcock, Joseph W., Hanson, M. Gartz, Gosgnach, Simon, Aimone, James B., Gage, Fred H., Lee, Kuo-Fen, Landmesser, Lynn T., Pfaff, Samuel L.
Published in Neuron (Cambridge, Mass.) (07.04.2005)
Published in Neuron (Cambridge, Mass.) (07.04.2005)
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Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration: Miniperspective
Siu, Michael, Sengupta Ghosh, Arundhati, Lewcock, Joseph W
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
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