Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
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Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
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Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
MENDEL, D. B, TAI, C. Y, LEW, W, WILLIAMS, M. A, ZHANG, L, CHEN, M. S, BISCHOFBERGER, N, KIM, C. U, ESCARPE, P. A, LI, W, SIDWELL, R. W, HUFFMAN, J. H, SWEET, C, JAKEMAN, K. J, MERSON, J, LACY, S. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
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Practical Total Synthesis of the Anti-Influenza Drug GS-4104
Rohloff, John C, Kent, Kenneth M, Postich, Michael J, Becker, Mark W, Chapman, Harlan H, Kelly, Daphne E, Lew, Willard, Louie, Michael S, McGee, Lawrence R, Prisbe, Ernest J, Schultze, Lisa M, Yu, Richard H, Zhang, Lijun
Published in Journal of organic chemistry (26.06.1998)
Published in Journal of organic chemistry (26.06.1998)
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Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
TAI, C. Y, ESCARPE, P. A, SIDWELL, R. W, WILLIAMS, M. A, LEW, W, HUIWEI WU, KIM, C. U, MENDEL, D. B
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
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Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C., Doerffler, Edward, Clarke, Michael O., Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M., Barauskas, Ona, Feng, Joy Y., Xu, Yili, Lee, Gary, Rheingold, Arnold L., Ray, Adrian S., Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A., Bavari, Sina, Cihlar, Tomas, Lo, Michael K., Warren, Travis K., Mackman, Richard L.
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Metabolism of the Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat
SWEENY, D. J, LYNCH, G, BIDGOOD, A. M, LEW, W, WANG, K.-Y, CUNDY, K. C
Published in Drug metabolism and disposition (01.07.2000)
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Published in Drug metabolism and disposition (01.07.2000)
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Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Williams, Matthew A., Lew, Willard, Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Laver, W.Graeme, Stevens, Raymond C., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
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Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients
Cho, Aesop, Zhang, Lijun, Xu, Jie, Lee, Rick, Butler, Thomas, Metobo, Sammy, Aktoudianakis, Vangelis, Lew, Willard, Ye, Hong, Clarke, Michael, Doerffler, Edward, Byun, Daniel, Wang, Ting, Babusis, Darius, Carey, Anne C., German, Polina, Sauer, Dorothea, Zhong, Weidong, Rossi, Stephen, Fenaux, Martijn, McHutchison, John G., Perry, Jason, Feng, Joy, Ray, Adrian S., Kim, Choung U.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Process Development and Scale-Up of a Protease Inhibitor for the Treatment of HIV Featuring the Preparation of a Neopentyl Grignard Reagent and Development of a One-Pot Curtius Reaction
Ischay, Michael A., Hoang, Brittanie, Steinhuebel, Dietrich P., Chin, Matthew R., Dixon, Darryl D., Elfgren, Danielle, Heumann, Lars, Lew, Willard, Mundal, Devon A., Neville, Sean T., Shah, Nisha P., Shi, Bing, Tripp, Jonathan C., Wang, Queenie
Published in Organic process research & development (16.09.2022)
Published in Organic process research & development (16.09.2022)
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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
MERIT JEFFREY E, WANG XIANGHONG, CHIN GREGORY F, LATHROP STEPHEN P, ZHENG ZEHUA, ASSELIN SYLVIE M, WENDERSKI TODD A, VIEIRA TIAGO, LEW WILLARD, AMBROSI ANDREA, PYUN HYUNG JUNG, BACHRACH FLORENCE J, METOBO SAMUEL E, MISH MICHAEL R, WEINSTEIN ADAM B, BADALOV PAVEL R, MACKMAN RICHARD L, REGENS CHRISTOPHER S, PRITCHETT BEAU P, AKTOUDIANAKIS EVANGELOS
Year of Publication 21.06.2024
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Year of Publication 21.06.2024
Patent
METHODS AND INTERMEDIATES FOR PREPARING A THERAPEUTIC COMPOUND USEFUL IN THE TREATMENT OF RETROVIRIDAE VIRAL INFECTION
WANG XIANGHONG, WONG CHLOE YUYI, BRIZGYS GEDIMINAS, GOLDBERG ALEX, STEINHUEBEL DIETRICH P, NGO VINH XUAN, HUANG ZILIN, TSE WINSTON C, HEUMANN LARS V, VANDEHEY AMANDA LYNN, LEW WILLARD, WOLCKENHAUER SCOTT ALAN, DHAR SACHIN, KAZERANI SHAHROKH, O'KEEFE BRIAN MICHAEL, ALLAN KEVIN MCCORMACK, ROBERTS BENJAMIN JAMES, DOXSEE IAN JAMES, SHI BING, KADUNCE NATHANIEL THOMAS, WAGNER ANNA MICHELLE, ZHANG JENNIFER R, RAINEY TREVOR JAMES
Year of Publication 17.10.2023
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Year of Publication 17.10.2023
Patent
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Kirschberg, Thorsten A., Metobo, Sammy, Clarke, Michael O., Aktoudianakis, Vangelis, Babusis, Darius, Barauskas, Ona, Birkus, Gabriel, Butler, Thomas, Byun, Daniel, Chin, Gregory, Doerffler, Edward, Edwards, Thomas E., Fenaux, Martijn, Lee, Rick, Lew, Willard, Mish, Michael R., Murakami, Eisuke, Park, Yeojin, Squires, Neil H., Tirunagari, Neeraj, Wang, Ting, Whitcomb, Mark, Xu, Jie, Yang, Huiling, Ye, Hong, Zhang, Lijun, Appleby, Todd C., Feng, Joy Y., Ray, Adrian S., Cho, Aesop, Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
Published in Bioorganic & medicinal chemistry letters (15.04.2017)
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Discovery of a potent and selective Aurora kinase inhibitor
Oslob, Johan D., Romanowski, Michael J., Allen, Darin A., Baskaran, Subramanian, Bui, Minna, Elling, Robert A., Flanagan, William M., Fung, Amy D., Hanan, Emily J., Harris, Shannon, Heumann, Stacey A., Hoch, Ute, Jacobs, Jeffrey W., Lam, Joni, Lawrence, Chris E., McDowell, Robert S., Nannini, Michelle A., Shen, Wang, Silverman, Jeffrey A., Sopko, Michelle M., Tangonan, Bradley T., Teague, Juli, Yoburn, Josh C., Yu, Chul H., Zhong, Min, Zimmerman, Kristin M., O’Brien, Tom, Lew, Willard
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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