Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L
Published in Journal of Medicinal Chemistry (09.03.2017)
Published in Journal of Medicinal Chemistry (09.03.2017)
Get full text
Journal Article
Web Resource
Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Published in Antimicrobial Agents and Chemotherapy (01.02.2013)
Get full text
Journal Article
Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors
Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C
Published in Journal of medicinal chemistry (02.07.1998)
Published in Journal of medicinal chemistry (02.07.1998)
Get full text
Journal Article
Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors
Hanan, Emily J., Fucini, Raymond V., Romanowski, Michael J., Elling, Robert A., Lew, Willard, Purkey, Hans E., VanderPorten, Erica C., Yang, Wenjin
Published in Bioorganic & medicinal chemistry (01.10.2008)
Published in Bioorganic & medicinal chemistry (01.10.2008)
Get full text
Journal Article
Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection
MENDEL, D. B, TAI, C. Y, LEW, W, WILLIAMS, M. A, ZHANG, L, CHEN, M. S, BISCHOFBERGER, N, KIM, C. U, ESCARPE, P. A, LI, W, SIDWELL, R. W, HUFFMAN, J. H, SWEET, C, JAKEMAN, K. J, MERSON, J, LACY, S. A
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Get full text
Journal Article
Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071
WEIXING LI, ESCARPE, P. A, KIM, C. U, BISCHOFBERGER, N, CHEN, M. S, MENDEL, D. B, EISENBERG, E. J, CUNDY, K. C, SWEET, C, JAKEMAN, K. J, MERSON, J, LEW, W, WILLIAMS, M, LIJUN ZHANG
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Published in Antimicrobial Agents and Chemotherapy (01.03.1998)
Get full text
Journal Article
Practical Total Synthesis of the Anti-Influenza Drug GS-4104
Rohloff, John C, Kent, Kenneth M, Postich, Michael J, Becker, Mark W, Chapman, Harlan H, Kelly, Daphne E, Lew, Willard, Louie, Michael S, McGee, Lawrence R, Prisbe, Ernest J, Schultze, Lisa M, Yu, Richard H, Zhang, Lijun
Published in Journal of organic chemistry (26.06.1998)
Published in Journal of organic chemistry (26.06.1998)
Get full text
Journal Article
Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071
TAI, C. Y, ESCARPE, P. A, SIDWELL, R. W, WILLIAMS, M. A, LEW, W, HUIWEI WU, KIM, C. U, MENDEL, D. B
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Published in Antimicrobial Agents and Chemotherapy (01.12.1998)
Get full text
Journal Article
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo(2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Siegel, Dustin, Hui, Hon C., Doerffler, Edward, Clarke, Michael O., Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M., Barauskas, Ona, Feng, Joy Y., Xu, Yili, Lee, Gary, Rheingold, Arnold L., Ray, Adrian S., Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A., Bavari, Sina, Cihlar, Tomas, Lo, Michael K., Warren, Travis K., Mackman, Richard L.
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
Get full text
Journal Article
Metabolism of the Influenza Neuraminidase Inhibitor Prodrug Oseltamivir in the Rat
SWEENY, D. J, LYNCH, G, BIDGOOD, A. M, LEW, W, WANG, K.-Y, CUNDY, K. C
Published in Drug metabolism and disposition (01.07.2000)
Get full text
Published in Drug metabolism and disposition (01.07.2000)
Journal Article
Discovery of the First C‑Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients
Cho, Aesop, Zhang, Lijun, Xu, Jie, Lee, Rick, Butler, Thomas, Metobo, Sammy, Aktoudianakis, Vangelis, Lew, Willard, Ye, Hong, Clarke, Michael, Doerffler, Edward, Byun, Daniel, Wang, Ting, Babusis, Darius, Carey, Anne C., German, Polina, Sauer, Dorothea, Zhong, Weidong, Rossi, Stephen, Fenaux, Martijn, McHutchison, John G., Perry, Jason, Feng, Joy, Ray, Adrian S., Kim, Choung U.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Structure-activity relationships of carbocyclic influenza neuraminidase inhibitors
Williams, Matthew A., Lew, Willard, Mendel, Dirk B., Tai, Chun Y., Escarpe, Paul A., Laver, W.Graeme, Stevens, Raymond C., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
Published in Bioorganic & medicinal chemistry letters (22.07.1997)
Get full text
Journal Article
Early Process Development of an LPAR1 Antagonist, GS-2278
Kadunce, Nathaniel, Wagner, Anna M., Cottell, Jeromy, Dao, Kathy, Dixon, Darryl D., Hodur, Blanka M., Holte, Dane, Ischay, Michael A., Kang, Jihun, Kim, Seongtaek, Kim, Young Ho, Koo, Seung Moh, Lew, Willard, Man, Lucas, Methuku, Kashi Reddy, Morrison, Henry, Parker, Patrick D., Siler, David A., Wong, Chloe Y.
Published in Organic process research & development (05.11.2024)
Published in Organic process research & development (05.11.2024)
Get full text
Journal Article
Process Development and Scale-Up of a Protease Inhibitor for the Treatment of HIV Featuring the Preparation of a Neopentyl Grignard Reagent and Development of a One-Pot Curtius Reaction
Ischay, Michael A., Hoang, Brittanie, Steinhuebel, Dietrich P., Chin, Matthew R., Dixon, Darryl D., Elfgren, Danielle, Heumann, Lars, Lew, Willard, Mundal, Devon A., Neville, Sean T., Shah, Nisha P., Shi, Bing, Tripp, Jonathan C., Wang, Queenie
Published in Organic process research & development (16.09.2022)
Published in Organic process research & development (16.09.2022)
Get full text
Journal Article
Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
METHODS FOR THE PREPARATION OF RIBOSIDES
WANG XIANGHONG, WOLFE LYDIA, VIEIRA TIAGO, WHITCOMB MARK CHARLES, GAO DETIAN, SCOTT ROBERT WILLIAM, LEW WILLARD, ROSS BRUCE, CAMPAGNA SILVIO, SIEGEL DUSTIN, TADEUS CLARISSA, HOANG BRITTANIE, YU CHIA YUN, DOERFFLER EDWARD, NEVILLE SEAN TIMOTHY, FRICK MORIN MAE, BRAK KATRIEN, WALTMAN ANDREW W, BADALOV PAVEL ROBERTOVICH, CHTELININE ANDREI, RUEDEN ERICK, HEUMANN LARS V, AXT STEVEN DONALD, STEVENS ANDREW C, MILBURN ROBERT RONALD
Year of Publication 20.08.2024
Get full text
Year of Publication 20.08.2024
Patent
PROCESSES FOR PREPARING TOLL-LIKE RECEPTOR MODULATOR COMPOUNDS
MERIT JEFFREY E, WANG XIANGHONG, CHIN GREGORY F, LATHROP STEPHEN P, ZHENG ZEHUA, ASSELIN SYLVIE M, WENDERSKI TODD A, VIEIRA TIAGO, LEW WILLARD, AMBROSI ANDREA, PYUN HYUNG JUNG, BACHRACH FLORENCE J, METOBO SAMUEL E, MISH MICHAEL R, WEINSTEIN ADAM B, BADALOV PAVEL R, MACKMAN RICHARD L, REGENS CHRISTOPHER S, PRITCHETT BEAU P, AKTOUDIANAKIS EVANGELOS
Year of Publication 21.06.2024
Get full text
Year of Publication 21.06.2024
Patent
C3-Thia and C3-carba isosteres of a carbocyclic influenza neuraminidase inhibitor, (3R,4R,5S)-4-acetamido-5-amino-3-propoxyl-1-cyclohexene-1-carboxylic acid
Lew, Willard, Williams, Matthew A., Mendel, Dirk B., Escarpe, Paul A., Kim, Choung U.
Published in Bioorganic & medicinal chemistry letters (01.07.1997)
Published in Bioorganic & medicinal chemistry letters (01.07.1997)
Get full text
Journal Article