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Published in Journal of medicinal chemistry (23.04.2009)
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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines
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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis
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Published in Bioorganic & medicinal chemistry (15.12.2005)
Published in Bioorganic & medicinal chemistry (15.12.2005)
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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design
Chen, James M, Nelson, Frances C, Levin, Jeremy I, Mobilio, Dominick, Moy, Franklin J, Nilakantan, Ramaswamy, Zask, Arie, Powers, Robert
Published in Journal of the American Chemical Society (11.10.2000)
Published in Journal of the American Chemical Society (11.10.2000)
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Impact of Mobility on Structure-Based Drug Design for the MMPs
Moy, Franklin J, Chanda, Pranab K, Chen, James, Cosmi, Scott, Edris, Wade, Levin, Jeremy I, Rush, Thomas S, Wilhelm, James, Powers, Robert
Published in Journal of the American Chemical Society (30.10.2002)
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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model
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Published in Bioorganic & medicinal chemistry letters (01.08.2011)
Published in Bioorganic & medicinal chemistry letters (01.08.2011)
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Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity
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Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-α converting enzyme (TACE) inhibitors
Park, Kaapjoo, Gopalsamy, Ariamala, Aplasca, Alexis, Ellingboe, John W., Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry (01.06.2009)
Published in Bioorganic & medicinal chemistry (01.06.2009)
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Late-stage optimization of a tercyclic class of S1P3-sparing, S1P1 receptor agonists
Horan, Joshua C., Kuzmich, Daniel, Liu, Pingrong, DiSalvo, Darren, Lord, John, Mao, Can, Hopkins, Tamara D., Yu, Hui, Harcken, Christian, Betageri, Raj, Hill-Drzewi, Melissa, Patenaude, Lori, Patel, Monica, Fletcher, Kimberly, Terenzzio, Donna, Linehan, Brian, Xia, Heather, Patel, Mita, Studwell, Debbie, Miller, Craig, Hickey, Eugene, Levin, Jeremy I., Smith, Dustin, Kemper, Raymond A., Modis, Louise K., Bannen, Lynne C., Chan, Diva S., Mac, Morrison B., Ng, Stephanie, Wang, Yong, Xu, Wei, Lemieux, René M.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Discovery of highly potent and selective type I B-Raf kinase inhibitors
Wang, Xiaolun, Berger, Dan M., Salaski, Edward J., Torres, Nancy, Hu, Yongbo, Levin, Jeremy I., Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
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Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model
Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Vogan, Erik, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity
Zapf, Christoph W., Bloom, Jonathan D., McBean, Jamie L., Dushin, Russell G., Nittoli, Thomas, Otteng, Mercy, Ingalls, Charles, Golas, Jennifer M., Liu, Hao, Lucas, Judy, Boschelli, Frank, Hu, Yongbo, Vogan, Erik, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors
Berger, Dan M., Torres, Nancy, Dutia, Minu, Powell, Dennis, Ciszewski, Greg, Gopalsamy, Ariamala, Levin, Jeremy I., Kim, Kyung-Hee, Xu, Weixin, Wilhelm, James, Hu, YongBo, Collins, Karen, Feldberg, Larry, Kim, Steven, Frommer, Eileen, Wojciechowicz, Donald, Mallon, Robert
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors
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Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Identification of potent and selective TACE inhibitors via the S1 pocket
Condon, Jeffrey S., Joseph-McCarthy, Diane, Levin, Jeremy I., Lombart, Henry-Georges, Lovering, Frank E., Sun, Linhong, Wang, Weiheng, Xu, Weixin, Zhang, Yuhua
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Identification of potent and selective MMP-13 inhibitors
Wu, Junjun, Rush, Thomas S., Hotchandani, Rajeev, Du, Xuemei, Geck, Mary, Collins, Elisabeth, Xu, Zhang-Bao, Skotnicki, Jerry, Levin, Jeremy I., Lovering, Frank E.
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
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Synthesis and activity of quinolinylmethyl P1′ α-sulfone piperidine hydroxamate inhibitors of TACE
Zhang, Chunchun, Lovering, Frank, Behnke, Mark, Zask, Arie, Sandanayaka, Vincent, Sun, Linhong, Zhu, Yi, Xu, Weixin, Zhang, Yuhua, Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
Published in Bioorganic & medicinal chemistry letters (01.07.2009)
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Synthesis and SAR of highly selective MMP-13 inhibitors
Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
Published in Bioorganic & medicinal chemistry letters (15.11.2005)
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