From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Ashkenazi, Avi, Fairbrother, Wayne J., Leverson, Joel D., Souers, Andrew J.
Published in Nature reviews. Drug discovery (01.04.2017)
Published in Nature reviews. Drug discovery (01.04.2017)
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
Pan, Rongqing, Ruvolo, Vivian, Mu, Hong, Leverson, Joel D., Nichols, Gwen, Reed, John C., Konopleva, Marina, Andreeff, Michael
Published in Cancer cell (11.12.2017)
Published in Cancer cell (11.12.2017)
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5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis
Jin, Sha, Cojocari, Dan, Purkal, Julie J, Popovic, Relja, Talaty, Nari N, Xiao, Yu, Solomon, Larry R, Boghaert, Erwin R, Leverson, Joel D, Phillips, Darren C
Published in Clinical cancer research (01.07.2020)
Published in Clinical cancer research (01.07.2020)
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Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Rahmani, Mohamed, Nkwocha, Jewel, Hawkins, Elisa, Pei, Xinyan, Parker, Rebecca E, Kmieciak, Maciej, Leverson, Joel D, Sampath, Deepak, Ferreira-Gonzalez, Andrea, Grant, Steven
Published in Cancer research (Chicago, Ill.) (01.06.2018)
Published in Cancer research (Chicago, Ill.) (01.06.2018)
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Potential mechanisms of resistance to venetoclax and strategies to circumvent it
Tahir, Stephen K, Smith, Morey L, Hessler, Paul, Rapp, Lisa Roberts, Idler, Kenneth B, Park, Chang H, Leverson, Joel D, Lam, Lloyd T
Published in BMC cancer (02.06.2017)
Published in BMC cancer (02.06.2017)
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Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM
Moreau, Philippe, Chanan-Khan, Asher, Roberts, Andrew W., Agarwal, Amit B., Facon, Thierry, Kumar, Shaji, Touzeau, Cyrille, Punnoose, Elizabeth A., Cordero, Jaclyn, Munasinghe, Wijith, Jia, Jia, Salem, Ahmed Hamed, Freise, Kevin J., Leverson, Joel D., Enschede, Sari Heitner, Ross, Jeremy A., Maciag, Paulo C., Verdugo, Maria, Harrison, Simon J.
Published in Blood (30.11.2017)
Published in Blood (30.11.2017)
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Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
Punnoose, Elizabeth A, Leverson, Joel D, Peale, Franklin, Boghaert, Erwin R, Belmont, Lisa D, Tan, Nguyen, Young, Amy, Mitten, Michael, Ingalla, Ellen, Darbonne, Walter C, Oleksijew, Anatol, Tapang, Paul, Yue, Peng, Oeh, Jason, Lee, Leslie, Maiga, Sophie, Fairbrother, Wayne J, Amiot, Martine, Souers, Andrew J, Sampath, Deepak
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W
Published in Nature medicine (01.02.2013)
Published in Nature medicine (01.02.2013)
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk‐Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.
Published in Molecular oncology (01.10.2020)
Published in Molecular oncology (01.10.2020)
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Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models
Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R, Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H, Jin, Sha S, Chen, Jun, Phillips, Darren C, Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K, DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M, Andreeff, Michael, Grant, Steven, Leverson, Joel D, Sampath, Deepak, Konopleva, Marina
Published in Haematologica (Roma) (01.03.2020)
Published in Haematologica (Roma) (01.03.2020)
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mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3- and Blimp-1-mediated BCL-2 upregulation
Osada, Naoki, Kikuchi, Jiro, Koyama, Daisuke, Kuroda, Yoshiaki, Yasui, Hiroshi, Leverson, Joel D, Furukawa, Yusuke
Published in Haematologica (Roma) (01.11.2021)
Published in Haematologica (Roma) (01.11.2021)
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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor
Xiao, Yu, Nimmer, Paul, Sheppard, George S, Bruncko, Milan, Hessler, Paul, Lu, Xin, Roberts-Rapp, Lisa, Pappano, William N, Elmore, Steven W, Souers, Andrew J, Leverson, Joel D, Phillips, Darren C
Published in Molecular cancer therapeutics (01.08.2015)
Published in Molecular cancer therapeutics (01.08.2015)
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Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR -Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target
Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad E, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C
Published in Clinical cancer research (15.11.2018)
Published in Clinical cancer research (15.11.2018)
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Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer
Zoeller, Jason J, Vagodny, Aleksandr, Daniels, Veerle W, Taneja, Krishan, Tan, Benjamin Y, DeRose, Yoko S, Fujita, Maihi, Welm, Alana L, Letai, Anthony, Leverson, Joel D, Blot, Vincent, Bronson, Roderick T, Dillon, Deborah A, Brugge, Joan S
Published in Breast cancer research : BCR (30.11.2020)
Published in Breast cancer research : BCR (30.11.2020)
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Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response
Zervantonakis, Ioannis K., Iavarone, Claudia, Chen, Hsing-Yu, Selfors, Laura M., Palakurthi, Sangeetha, Liu, Joyce F., Drapkin, Ronny, Matulonis, Ursula, Leverson, Joel D., Sampath, Deepak, Mills, Gordon B., Brugge, Joan S.
Published in Nature communications (28.08.2017)
Published in Nature communications (28.08.2017)
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Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells
Ludwig, Lindsey M., Hawley, Katrina M., Banks, David B., Thomas-Toth, Anika T., Blazar, Bruce R., McNerney, Megan E., Leverson, Joel D., LaBelle, James L.
Published in Cell death & disease (27.10.2021)
Published in Cell death & disease (27.10.2021)
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Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
Zhu, Changjun, Zhao, Jian, Bibikova, Marina, Leverson, Joel D, Bossy-Wetzel, Ella, Fan, Jian-Bing, Abraham, Robert T, Jiang, Wei
Published in Molecular biology of the cell (01.07.2005)
Published in Molecular biology of the cell (01.07.2005)
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