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Riether, Carsten, Pabst, Thomas, Höpner, Sabine, Bacher, Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Muller, Rouven, Manz, Markus G, Gharib, Walid H, Francisco, David, Bruggmann, Remy, van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, de Haard, Hans, Leupin, Nicolas, Ochsenbein, Adrian F
Published in Nature medicine (01.09.2020)
Published in Nature medicine (01.09.2020)
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Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans
Ulrichts, Peter, Guglietta, Antonio, Dreier, Torsten, van Bragt, Tonke, Hanssens, Valérie, Hofman, Erik, Vankerckhoven, Bernhardt, Verheesen, Peter, Ongenae, Nicolas, Lykhopiy, Valentina, Enriquez, F Javier, Cho, JunHaeng, Ober, Raimund J, Ward, E Sally, de Haard, Hans, Leupin, Nicolas
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Phase I Dose-Escalation Study of the Anti-CD70 Antibody ARGX-110 in Advanced Malignancies
Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Offner, Fritz, Bron, Dominique, Maerevoet, Marie, Soria, Jean-Charles, Moshir, Mahan, Dreier, Torsten, Van Rompaey, Luc, Michot, Jean-Marie, Silence, Karen, Hultberg, Anna, Gandini, Domenica, de Haard, Hans, Ribrag, Vincent, Peeters, Marc, Thibault, Alain, Leupin, Nicolas, Awada, Ahmad
Published in Clinical cancer research (01.11.2017)
Published in Clinical cancer research (01.11.2017)
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Impact of renal impairment on outcomes with lenalidomide and dexamethasone treatment in the FIRST trial, a randomized, open-label phase 3 trial in transplant-ineligible patients with multiple myeloma
Dimopoulos, Meletios A, Cheung, Matthew C, Roussel, Murielle, Liu, Ting, Gamberi, Barbara, Kolb, Brigitte, Derigs, H Guenter, Eom, HyeonSeok, Belhadj, Karim, Lenain, Pascal, Van der Jagt, Richard, Rigaudeau, Sophie, Dib, Mamoun, Hall, Rachel, Jardel, Henry, Jaccard, Arnaud, Tosikyan, Axel, Karlin, Lionel, Bensinger, William, Schots, Rik, Leupin, Nicolas, Chen, Guang, Marek, Jennifer, Ervin-Haynes, Annette, Facon, Thierry
Published in Haematologica (Roma) (01.03.2016)
Published in Haematologica (Roma) (01.03.2016)
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The NHance® Mutation-Equipped Anti-MET Antibody ARGX-111 Displays Increased Tissue Penetration and Anti-Tumor Activity in Advanced Cancer Patients
Aftimos, Philippe, Rolfo, Christian, Rottey, Sylvie, Barthélémy, Philippe, Borg, Christophe, Park, Keunchil, Oh, Do-Youn, Kim, Sang-We, De Jonge, Natalie, Hanssens, Valérie, Zwanenpoel, Karen, Molthoff, Carla, Vugts, Daniëlle, Dreier, Torsten, Verheesen, Peter, van Dongen, Guus A.M.S., Jacobs, Julie, Van Rompaey, Luc, Hultberg, Anna, Michieli, Paolo, Pauwels, Patrick, Fung, Samson, Thibault, Alain, de Haard, Hans, Leupin, Nicolas, Awada, Ahmad
Published in Biomedicines (10.06.2021)
Published in Biomedicines (10.06.2021)
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The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells
Rizzi, Mattia, Tschan, Mario P., Britschgi, Christian, Britschgi, Adrian, Hügli, Barbara, Grob, Tobias J., Leupin, Nicolas, Mueller, Beatrice U., Simon, Hans‐Uwe, Ziemiecki, Andrew, Torbett, Bruce E., Fey, Martin F., Tobler, Andreas
Published in Journal of leukocyte biology (01.06.2007)
Published in Journal of leukocyte biology (01.06.2007)
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Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia
Newland, Adrian C., Sánchez‐González, Blanca, Rejtő, László, Egyed, Miklos, Romanyuk, Nataliya, Godar, Marie, Verschueren, Katrien, Gandini, Domenica, Ulrichts, Peter, Beauchamp, Jon, Dreier, Torsten, Ward, E. Sally, Michel, Marc, Liebman, Howard A., Haard, Hans, Leupin, Nicolas, Kuter, David J.
Published in American journal of hematology (01.02.2020)
Published in American journal of hematology (01.02.2020)
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MP0533, a CD3-Engaging Darpin Targeting CD33, CD123, and CD70 in Patients with Relapsed/Refractory AML or MDS/AML: Preliminary Results of a Phase 1/2a Study
Pabst, Thomas, Jongen-Lavrencic, Mojca, Boettcher, Steffen, Huls, Geert A., de Leeuw, David C., Legenne, Philippe, Dymkowska, Mariola, Andrieu, Christiane, Schönborn-Kellenberger, Oliver, Baverel, Paul G., Arany, Zita, Fernandez, Elena, Goubier, Anne, Kirkin, Vladimir, Leupin, Nicolas, Subklewe, Marion
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Updated Outcomes and Impact of Age With Lenalidomide and Low-Dose Dexamethasone or Melphalan, Prednisone, and Thalidomide in the Randomized, Phase III FIRST Trial
Hulin, Cyrille, Belch, Andrew, Shustik, Chaim, Petrucci, Maria Teresa, Dührsen, Ulrich, Lu, Jin, Song, Kevin, Rodon, Philippe, Pégourié, Brigitte, Garderet, Laurent, Hunter, Hannah, Azais, Isabelle, Eek, Richard, Gisslinger, Heinz, Macro, Margaret, Dakhil, Shaker, Goncalves, Cristina, LeBlanc, Richard, Romeril, Ken, Royer, Bruno, Doyen, Chantal, Leleu, Xavier, Offner, Fritz, Leupin, Nicolas, Houck, Vanessa, Chen, Guang, Ervin-Haynes, Annette, Dimopoulos, Meletios A, Facon, Thierry
Published in Journal of clinical oncology (20.10.2016)
Published in Journal of clinical oncology (20.10.2016)
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First-in-Human Phase I Study of MP0250, a First-in-Class DARPin Drug Candidate Targeting VEGF and HGF, in Patients With Advanced Solid Tumors
Baird, Richard D, Linossi, Constanza, Middleton, Mark, Lord, Simon, Harris, Adrian, Rodón, Jordi, Zitt, Christof, Fiedler, Ulrike, Dawson, Keith M, Leupin, Nicolas, Stumpp, Michael T, Harstrick, Andreas, Azaro, Analía, Fischer, Stefanie, Omlin, Aurelius
Published in Journal of clinical oncology (10.01.2021)
Published in Journal of clinical oncology (10.01.2021)
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MP0533: A Multispecific Darpin CD3 Engager Targeting CD33, CD123, and CD70 for the Treatment of AML and MDS Designed to Selectively Target Leukemic Stem Cells
Bianchi, Matteo, Reichen, Christian, Fischer, Stefanie, Grübler, Yvonne, Eggenschwiler, Aline, Marpakwar, Rajlakshmi, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Kaufmann, Yvonne, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Lekishvili, Tamara, Frasconi, Teresa, Wullschleger, Stephan, Zitt, Christof, Franchini, Marco, Croset, Amelie, Watson, Randall, Kirkin, Vladimir, Luethi, Ursina, Ochsenbein, Adrian, Riether, Carsten, Steiner, Daniel, Leupin, Nicolas, Goubier, Anne
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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The Combination of the BCL-2 Antagonist Venetoclax with the CD70-Targeting Antibody Cusatuzumab Synergistically Eliminates Primary Human Leukemia Stem Cells
Riether, Carsten, Chiorazzo, Tanja, Johnson, Amy J., Drenberg, Christina Diane, Syed, Khaja Waheeduddin, Moshir, Mahan, Hultberg, Anna, Leupin, Nicolas, De Haard, Hans, Ochsenbein, Adrian F
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Argx-113, a Novel Fc-Based Approach for Antibody-Induced Pathologies Such As Primary Immune Thrombocytopenia
Ulrichts, Peter, Cousin, Thierry, Dreier, Torsten, de Haard, Hans, Leupin, Nicolas
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Cusatuzumab for treatment of CD70‐positive relapsed or refractory cutaneous T‐cell lymphoma
Leupin, Nicolas, Zinzani, Pier Luigi, Morschhauser, Franck, Dalle, Stéphane, Maerevoet, Marie, Michot, Jean‐Marie, Ribrag, Vincent, Offner, Fritz, Beylot‐Barry, Marie, Moins‐Teisserenc, Hélène, Zwaenepoel, Karen, Winne, Koen, Battistella, Maxime, Hultberg, Anna, Gandini, Domenica, Moshir, Mahan, Jacobs, Julie, Delahaye, Tim, Khan, Aitzaz, Zabrocki, Piotr, Silence, Karen, Rompaey, Luc, Borg, Christophe, Motta, Giovanna, Melle, Federica, Calleri, Angelica, Pauwels, Patrick, Haard, Hans, Pileri, Stefano, Bagot, Martine
Published in Cancer (01.03.2022)
Published in Cancer (01.03.2022)
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Phase 2 Study of Efgartigimod, a Novel FcRn Antagonist, in Adult Patients with Primary Immune Thrombocytopenia
Newland, Adrian C., Sánchez-González, Blanca, Rejtő, László, Egyed, Miklos, Romanyuk, Nataliya, Godar, Marie, Verschueren, Katrien, Gandini, Domenica, Ulrichts, Peter, Beauchamp, Jon, Dreier, Torsten, Ward, E. Sally, Michel, Marc, Liebman, Howard A., De Haard, Hans, Leupin, Nicolas, Kuter, David J.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Blocking CD70/CD27 Signaling in Combination with Hypomethylating Agents Eradicates Human CD34+ AML Stem and Progenitor Cells in Vitro and In Vivo
Hinterbrandner, Magdalena, Kallen, Nils Maria, Lüthi, Ursina, Pabst, Thomas, Van Rompaey, Luc, Leupin, Nicolas, De Haard, Hans, Ochsenbein, Adrian F, Riether, Carsten
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans
Ulrichts, Peter, Guglietta, Antonio, Dreier, Torsten, Bragt, Tonke van, Hanssens, Valérie, Hofman, Erik, Vankerckhoven, Bernhardt, Verheesen, Peter, Ongenae, Nicolas, Lykhopiy, Valentina, Enriquez, F Javier, Cho, JunHaeng, Ober, Raimund J, Ward, E Sally, de Haard, Hans, Leupin, Nicolas
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
Targeting CD70 with Cusatuzumab Eliminates Acute Myeloid Leukemia Stem Cells in Humans
Ochsenbein, Adrian F, Pabst, Thomas, Höpner, Sabine, Bacher, Vera Ulrike, Hinterbrandner, Magdalena, Banz, Yara, Müller, Rouven, Manz, Markus G., Gharib, Walid, Francisco, David, Bruggmann, Rémy, Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Riether, Carsten
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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The CD33xCD123xCD70 Multispecific CD3-Engaging DARPin MP0533 Induces Selective T Cell-Mediated Killing of AML Leukemic Stem Cells
Bianchi, Matteo, Reichen, Christian, Croset, Amelie, Fischer, Stefanie, Eggenschwiler, Aline, Grübler, Yvonne, Marpakwar, Rajlakshmi, Looser, Thamar, Spitzli, Patricia, Herzog, Christel, Villemagne, Denis, Schiegg, Dieter, Abduli, Liridon, Iss, Chloé, Neculcea, Alexandra, Franchini, Marco, Lekishvili, Tamara, Ragusa, Simone, Zitt, Christof, Kaufmann, Yvonne, Auge, Alienor, Hänggi, Martin, Ali, Waleed, Frasconi, Teresa M, Wullschleger, Stephan, Schlegel, Iris, Matzner, Mirela, Lüthi, Ursina, Schlereth, Bernd, Dawson, Keith M, Kirkin, Vladimir, Ochsenbein, Adrian F, Grimm, Sebastian, Reschke, Nina, Riether, Carsten, Steiner, Daniel, Leupin, Nicolas, Goubier, Anne
Published in Cancer immunology research (02.07.2024)
Published in Cancer immunology research (02.07.2024)
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Argx-110 Targeting CD70, in Combination with Azacitidine, Shows Favorable Safety Profile and Promising Anti-Leukemia Activity in Newly Diagnosed AML Patients in an Ongoing Phase 1/2 Clinical Trial
Ochsenbein, Adrian F, Riether, Carsten, Bacher, Ulrike, Müller, Rouven, Höpner, Sabine, Banz, Yara, Hinterbrandner, Magdalena, Bargetzi, Mario, Manz, Markus G., Van Rompaey, Luc, Moshir, Mahan, Delahaye, Tim, Gandini, Domenica, Erzeel, Ellen, Hultberg, Anna, Fung, Samson, De Haard, Hans, Leupin, Nicolas, Pabst, Thomas
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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