A randomised, controlled single and multiple ascending dose trial of the safety, pharmacokinetics and pharmacodynamics of SN1011 in healthy subjects
Zhu, Leilei, Shi, Rong, Zhao, Tongfang, Ye, Yujie, Tang, Jie, Hu, Yihui, Peng, Peng, Wang, Dong, Chong, Clement, Xu, Guolin, Leung, Shui-On, Yuan, Wei'an
Published in Clinical and translational science (01.10.2023)
Published in Clinical and translational science (01.10.2023)
Get full text
Journal Article
SM03, an anti-human CD22 monoclonal antibody, for active rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled study
Li, Jing, Li, Mengtao, Wu, Di, Zhou, Jiaxin, Leung, Shui-on, Zhang, Fengchun
Published in Rheumatology (Oxford, England) (05.05.2022)
Published in Rheumatology (Oxford, England) (05.05.2022)
Get full text
Journal Article
An open-label, multiple-dose study to assess the preliminary pharmacokinetics, pharmacodynamics, clinical activity, and safety of human mouse chimeric anti-CD22 monoclonal antibody (SM03) in patients with rheumatoid arthritis
Zhao, Qian, Chen, Xia, Jiang, Ji, Li, Jing, Zhong, Wen, Han, Hongcan, Li, Zhengdong, Leung, Shui-on, Zhang, Fengchun, Hu, Pei
Published in International journal of clinical pharmacology and therapeutics (01.11.2021)
Published in International journal of clinical pharmacology and therapeutics (01.11.2021)
Get full text
Journal Article
Pharmacokinetics, Pharmacodynamics and Preliminary Observations for Clinical Activity and Safety of Multiple Doses of Human Mouse Chimeric Anti-CD22 Monoclonal Antibody (SM03) in Chinese Patients with Systemic Lupus Erythematosus
Zhao, Qian, Chen, Xia, Li, Jing, Jiang, Ji, Li, Mengtao, Zhong, Wen, Li, Zhengdong, Leung, Shui-on, Zhang, Fengchun, Hu, Pei
Published in Clinical drug investigation (01.11.2016)
Published in Clinical drug investigation (01.11.2016)
Get full text
Journal Article
Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody
Leung, Shui-On, Gao, Kai, Wang, Guang Yu, Cheung, Benny Ka-Wa, Lee, Kwan-Yeung, Zhao, Qi, Cheung, Wing-Tai, Wang, Jun Zhi
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
Get full text
Journal Article
Generation of a high‐producing clone of a humanized anti‐B‐cell lymphoma monoclonal antibody (hLL2)
Losman, Michele J., Hansen, Hans J., Dworak, Heather, Krishnan, Indira S., Qu, Zhengxing, Shih, Lisa B., Zeng, Li, Goldenberg, David M., Leung, Shui‐on
Published in Cancer (15.12.1997)
Published in Cancer (15.12.1997)
Get full text
Journal Article
Conference Proceeding
513 - Blockage of IL-25 pathway as a potential target therapy for atopic dermatitis
Hui, Thomas Chin Wai, Lam, Lik Hang, Li, Weimin, Chow, Kai Cheung, Leung, Shui On
Published in British journal of dermatology (1951) (07.02.2024)
Published in British journal of dermatology (1951) (07.02.2024)
Get full text
Journal Article
Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2
Leung, Shui-on, Goldenberg, David M., Dion, Arnold S., Pellegrini, Matthew C., Shevitz, Jerry, Shih, Lisa B., Hansen, Hans J.
Published in Molecular immunology (01.12.1995)
Published in Molecular immunology (01.12.1995)
Get full text
Journal Article
Effect of VK framework-1 glycosylation on the binding affinity of lymphoma-specific murine and chimeric LL2 antibodies and its potential use as a novel conjugation site
Leung, S O, Dion, A S, Pellegrini, M C, Losman, M J, Grebenau, R C, Goldenberg, D M, Hansen, H J
Published in International journal of cancer (08.02.1995)
Published in International journal of cancer (08.02.1995)
Get more information
Journal Article
SM 17, a new IL ‐17 RB ‐targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis
Lam, Lik Hang, Li, Weimin, Wu, Wai Chung, Chow, Kai Cheung, Au, Wai Yin Dennis, Xu, Guolin, Wang, Ge, Qian, Xuchen, Ng, Ka Man, Nawabjan, Shaik Abdullah, Gandhi Sethuraman, Muthu Iswarya, Choi, Wai Yan, Chow, Billy Kwok Chong, Leung, Shui On, Hui, Chin Wai
Published in Allergy (Copenhagen) (01.06.2024)
Published in Allergy (Copenhagen) (01.06.2024)
Get full text
Journal Article
SM17, a new IL‐17RB‐targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis
Lam, Lik Hang, Li, Weimin, Wu, Wai Chung, Chow, Kai Cheung, Au, Wai Yin Dennis, Xu, Guolin, Wang, Ge, Qian, Xuchen, Ng, Ka Man, Nawabjan, Shaik Abdullah, Gandhi Sethuraman, Muthu Iswarya, Choi, Wai Yan, Chow, Billy Kwok Chong, Leung, Shui On, Hui, Chin Wai
Published in Allergy (Copenhagen) (01.06.2024)
Published in Allergy (Copenhagen) (01.06.2024)
Get full text
Journal Article
The Effects of Domain Deletion, Glycosylation, and Long IgG3 Hinge on the Biodistribution and Serum Stability Properties of a Humanized IgG1 Immunoglobulin, hLL2, and Its Fragments
Leung, S O, Qu, Z, Hansen, H J, Shih, L B, Wang, J, Losman, M J, Goldenberg, D M, Sharkey, R M
Published in Clinical cancer research (01.10.1999)
Get full text
Published in Clinical cancer research (01.10.1999)
Journal Article
Generation and Monitoring of Cell Lines Producing Humanized Antibodies
Losman, M J, Qu, Z, Krishnan, I S, Wang, J, Hansen, H J, Goldenberg, D M, Leung, S O
Published in Clinical cancer research (01.10.1999)
Get full text
Published in Clinical cancer research (01.10.1999)
Journal Article
Humanization of Immu31, an α-Fetoprotein-specific Antibody
Qu, Z, Losman, M J, Eliassen, K C, Hansen, H J, Goldenberg, D M, Leung, S O
Published in Clinical cancer research (01.10.1999)
Get full text
Published in Clinical cancer research (01.10.1999)
Journal Article
Carbohydrates engineered at antibody constant domains can be used for site-specific conjugation of drugs and chelates
Qu, Zhengxing, Sharkey, Robert M, Hansen, Hans J, Shih, Lisa B, Govindan, Serengulam V, Shen, Jian, Goldenberg, David M, Leung, Shui-on
Published in Journal of immunological methods (15.04.1998)
Published in Journal of immunological methods (15.04.1998)
Get full text
Journal Article